• Je něco špatně v tomto záznamu ?

G-Quadruplexes in the Archaea Domain

V. Brázda, Y. Luo, M. Bartas, P. Kaura, O. Porubiaková, J. Šťastný, P. Pečinka, D. Verga, V. Da Cunha, TS. Takahashi, P. Forterre, H. Myllykallio, M. Fojta, JL. Mergny

. 2020 ; 10 (9) : . [pub] 20200921

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026556

Grantová podpora
CZ.02.1.01/0.0/0.0/15_003/0000477 ERDF - International
18-15548S Grantová Agentura České Republiky - International

The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial, and eukaryotic genomes, including humans. Here, we performed the first systematic search of G4-forming sequences in all archaeal genomes available in the NCBI database. In this article, we investigate the presence and locations of G-quadruplex forming sequences using the G4Hunter algorithm. G-quadruplex-prone sequences were identified in all archaeal species, with highly significant differences in frequency, from 0.037 to 15.31 potential quadruplex sequences per kb. While G4 forming sequences were extremely abundant in Hadesarchaea archeon (strikingly, more than 50% of the Hadesarchaea archaeon isolate WYZ-LMO6 genome is a potential part of a G4-motif), they were very rare in the Parvarchaeota phylum. The presence of G-quadruplex forming sequences does not follow a random distribution with an over-representation in non-coding RNA, suggesting possible roles for ncRNA regulation. These data illustrate the unique and non-random localization of G-quadruplexes in Archaea.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc21026556
003      
CZ-PrNML
005      
20211026132816.0
007      
ta
008      
211013s2020 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/biom10091349 $2 doi
035    __
$a (PubMed)32967357
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Brázda, Václav $u Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech Republic
245    10
$a G-Quadruplexes in the Archaea Domain / $c V. Brázda, Y. Luo, M. Bartas, P. Kaura, O. Porubiaková, J. Šťastný, P. Pečinka, D. Verga, V. Da Cunha, TS. Takahashi, P. Forterre, H. Myllykallio, M. Fojta, JL. Mergny
520    9_
$a The importance of unusual DNA structures in the regulation of basic cellular processes is an emerging field of research. Amongst local non-B DNA structures, G-quadruplexes (G4s) have gained in popularity during the last decade, and their presence and functional relevance at the DNA and RNA level has been demonstrated in a number of viral, bacterial, and eukaryotic genomes, including humans. Here, we performed the first systematic search of G4-forming sequences in all archaeal genomes available in the NCBI database. In this article, we investigate the presence and locations of G-quadruplex forming sequences using the G4Hunter algorithm. G-quadruplex-prone sequences were identified in all archaeal species, with highly significant differences in frequency, from 0.037 to 15.31 potential quadruplex sequences per kb. While G4 forming sequences were extremely abundant in Hadesarchaea archeon (strikingly, more than 50% of the Hadesarchaea archaeon isolate WYZ-LMO6 genome is a potential part of a G4-motif), they were very rare in the Parvarchaeota phylum. The presence of G-quadruplex forming sequences does not follow a random distribution with an over-representation in non-coding RNA, suggesting possible roles for ncRNA regulation. These data illustrate the unique and non-random localization of G-quadruplexes in Archaea.
650    _2
$a Archaea $x klasifikace $x genetika $x metabolismus $7 D001105
650    _2
$a archeální proteiny $x genetika $x metabolismus $7 D019843
650    _2
$a cirkulární dichroismus $7 D002942
650    _2
$a DNA $x chemie $x genetika $x metabolismus $7 D004247
650    _2
$a DNA vazebné proteiny $x genetika $x metabolismus $7 D004268
650    12
$a G-kvadruplexy $7 D054856
650    _2
$a genom archeí $x genetika $7 D020745
650    _2
$a genomika $x metody $7 D023281
650    _2
$a konformace nukleové kyseliny $7 D009690
650    _2
$a fylogeneze $7 D010802
650    _2
$a RNA $x chemie $x genetika $x metabolismus $7 D012313
650    _2
$a druhová specificita $7 D013045
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Luo, Yu $u Institut Curie, CNRS UMR9187, INSERM U1196, Universite Paris Saclay, 91400 Orsay, France
700    1_
$a Bartas, Martin $u Department of Biology and Ecology/Institute of Environmental Technologies, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
700    1_
$a Kaura, Patrik $u Faculty of Mechanical Engineering, Brno University of Technology, Technicka 2896/2, 616 69 Brno, Czech Republic
700    1_
$a Porubiaková, Otilia $u Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech Republic $u Faculty of Chemistry, Brno University of Technology, Purkyňova 464/118, 612 00 Brno, Czech Republic
700    1_
$a Šťastný, Jiří $u Faculty of Mechanical Engineering, Brno University of Technology, Technicka 2896/2, 616 69 Brno, Czech Republic $u Mendel University in Brno, Zemědělská 1, 613 00 Brno, Czech Republic
700    1_
$a Pečinka, Petr $u Department of Biology and Ecology/Institute of Environmental Technologies, Faculty of Science, University of Ostrava, 710 00 Ostrava, Czech Republic
700    1_
$a Verga, Daniela $u Institut Curie, CNRS UMR9187, INSERM U1196, Universite Paris Saclay, 91400 Orsay, France
700    1_
$a Da Cunha, Violette $u Institut de Biologie Intégrative de la Cellule (I2BC), CNRS, Université Paris-Saclay, CEDEX, 91198 Gif-sur-Yvette, France
700    1_
$a Takahashi, Tomio S $u Institut de Biologie Intégrative de la Cellule (I2BC), CNRS, Université Paris-Saclay, CEDEX, 91198 Gif-sur-Yvette, France
700    1_
$a Forterre, Patrick $u Institut de Biologie Intégrative de la Cellule (I2BC), CNRS, Université Paris-Saclay, CEDEX, 91198 Gif-sur-Yvette, France
700    1_
$a Myllykallio, Hannu $u Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, 91128 Palaiseau, France
700    1_
$a Fojta, Miroslav $u Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech Republic
700    1_
$a Mergny, Jean-Louis $u Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 65 Brno, Czech Republic $u Laboratoire d'Optique et Biosciences, Ecole Polytechnique, CNRS, INSERM, Institut Polytechnique de Paris, 91128 Palaiseau, France
773    0_
$w MED00188737 $t Biomolecules $x 2218-273X $g Roč. 10, č. 9 (2020)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/32967357 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20211013 $b ABA008
991    __
$a 20211026132822 $b ABA008
999    __
$a ok $b bmc $g 1715321 $s 1147063
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 10 $c 9 $e 20200921 $i 2218-273X $m Biomolecules $n Biomolecules $x MED00188737
GRA    __
$a CZ.02.1.01/0.0/0.0/15_003/0000477 $p ERDF $2 International
GRA    __
$a 18-15548S $p Grantová Agentura České Republiky $2 International
LZP    __
$a Pubmed-20211013
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace