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Human microbial metabolite mimicry as a strategy to expand the chemical space of potential drugs

H. Li, HS. Ranhotra, S. Mani, Z. Dvořák, H. Sokol, R. Müller

. 2020 ; 25 (9) : 1575-1579. [pub] 20200617

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc21026572

Grantová podpora
R01 CA222469 NCI NIH HHS - United States
R01 ES030197 NIEHS NIH HHS - United States

The concept of small-molecule mimicry even of weak microbial metabolites present in rodents and humans, as a means to expand drug repertoires, is new. Hitherto, there are few proof-of-concept papers demonstrating utility of this concept. More recently, papers demonstrating mimicry of intestinal microbial metabolites could expand the drug repertoire for diseases such as inflammatory bowel disease (IBD). We opine that, as more functional metabolite-receptor pairings are discovered, small-molecule metabolite mimicry could be a significant effort in drug discovery.

Citace poskytuje Crossref.org

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$a Dvořák, Zdeněk $u Department of Cell Biology and Genetics, Palacký University, Olomouc 78371, Czech Republic. Electronic address: moulin@email.cz
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$a Sokol, Harry $u Sorbonne Université, Inserm, Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Service de Gastroenterologie, F-75012 Paris, France; INRA, UMR1319 Micalis & AgroParisTech, Jouy en Josas, 78352, France; Paris Centre for Microbiome Medicine FHU, Paris, France. Electronic address: harry.sokol@aphp.fr
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$a Müller, Rolf $u Helmholtz Center for Infection Research, GmbH Inhoffenstrasse, 738124 Braunschweig, Germany; Department of Microbial Natural Products, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)University campus E8, 166123 Saarbrücken, Germany; German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Germany. Electronic address: Rolf.Mueller@helmholtz-hips.de
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