• Je něco špatně v tomto záznamu ?

The role of connexin 37 polymorphism in spontaneous abortion

M. Kníže, J. Piťha, J. A. Hubacek, T. Fait

. 2021 ; 70 (3) : 469-474. [pub] 20210512

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22000854

Among unique cardiovascular risk factors in women are complications during pregnancy, including miscarriage. Important risk factor is also genetic background. One of powerful candidate genes for cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with strong gene-environment interaction including smoking status, that is also strong risk factor for complications in pregnancy including spontaneous abortion (SA). We analyzed association between SA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 fetuses and its potential interaction with smoking status of mothers. Using genetic analyses from women from general population as controls, ORs for T allele, found in our previous studies to be protective against aCVD, were calculated. T allele carriers (fetuses), had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significant association between Cx37 polymorphism and SA was observed and no modifying effect of smoking status on this association was detected.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc22000854
003      
CZ-PrNML
005      
20220202102400.0
007      
ta
008      
220106s2021 xr f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934566 $2 doi
035    __
$a (PubMed)33982579
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Kníže, Michal $7 xx0232744 $u Department of Obstetrics and Gynecology, Motol University Hospital, Prague, Czech Republic
245    14
$a The role of connexin 37 polymorphism in spontaneous abortion / $c M. Kníže, J. Piťha, J. A. Hubacek, T. Fait
504    __
$a Literatura
520    9_
$a Among unique cardiovascular risk factors in women are complications during pregnancy, including miscarriage. Important risk factor is also genetic background. One of powerful candidate genes for cardiovascular disease of atherosclerotic origin (aCVD) is gene for connexin 37 (Cx37) with strong gene-environment interaction including smoking status, that is also strong risk factor for complications in pregnancy including spontaneous abortion (SA). We analyzed association between SA and Cx37 gene polymorphism (1019C>T; Pro319Ser) in 547 fetuses and its potential interaction with smoking status of mothers. Using genetic analyses from women from general population as controls, ORs for T allele, found in our previous studies to be protective against aCVD, were calculated. T allele carriers (fetuses), had OR 0.91 (95 % CI 0.72-1.14) and no interaction with smoking was observed. In conclusion, no significant association between Cx37 polymorphism and SA was observed and no modifying effect of smoking status on this association was detected.
650    _2
$a samovolný potrat $x genetika $7 D000022
650    _2
$a dospělí $7 D000328
650    _2
$a biologické markery $7 D015415
650    _2
$a konexiny $x genetika $7 D017630
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a plod $7 D005333
650    _2
$a genetická predispozice k nemoci $7 D020022
650    _2
$a heterozygot $7 D006579
650    _2
$a lidé $7 D006801
650    _2
$a novorozenec $7 D007231
650    _2
$a lidé středního věku $7 D008875
650    _2
$a polymorfismus genetický $7 D011110
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    _2
$a těhotenství $7 D011247
650    _2
$a rizikové faktory $7 D012307
650    _2
$a kouření $7 D012907
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
700    1_
$a Piťha, Jan, $d 1964- $7 mzk2003187379 $u Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Hubáček, Jaroslav, $d 1966- $7 nlk20050169367 $u Centre for Experimental Medicine, Institute of Clinical and Experimental Medicine, Prague, Czech Republic $u Third Department of Internal Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Fait, Tomáš, $d 1971- $7 xx0053331 $u Department of Obstetrics and Gynecology, Motol University Hospital, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 70, č. 3 (2021), s. 469-474
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33982579 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20220106 $b ABA008
991    __
$a 20220202102350 $b ABA008
999    __
$a ok $b bmc $g 1755685 $s 1152000
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 70 $c 3 $d 469-474 $e 20210512 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20220106

Najít záznam

Citační ukazatele

Možnosti archivace