The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.

Clinic of Dermal and Venereal Diseases University Hospital Hradec Kralove Czech Republic

Institute of Clinical Biochemistry and Diagnostics University Hospital and Faculty of Medicine in Hradec Kralove Charles University Hradec Kralove Czech Republic

Institute of Clinical Immunology and Allergology University Hospital and Faculty of Medicine in Hradec Kralove Charles University Hradec Kralove Czech Republic

Institute of Pathological Physiology Faculty of Medicine in Hradec Kralove Charles University Hradec Kralove Czech Republic

Institute of Preventive Medicine Faculty of Medicine in Hradec Kralove Charles University Hradec Kralove Czech Republic

Transfusion Center University Hospital Hradec Kralove Czech Republic

Literatura

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$a Borský, Pavel $7 xx0268728 $u Institute of Preventive Medicine, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic

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$a C-reactive protein, chemerin, fetuin-A and osteopontin as predictors of cardiovascular risks in persons with psoriasis vulgaris / $c P. Borsky, Z. Fiala, C. Andrys, M. Beranek, K. Hamakova, J. Kremlacek, A. Malkova, T. Svadlakova, J. Krejsek, V. Palicka, V. Rehacek, L. Kotingova, L. Borska

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$a The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.

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