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C-reactive protein, chemerin, fetuin-A and osteopontin as predictors of cardiovascular risks in persons with psoriasis vulgaris
P. Borsky, Z. Fiala, C. Andrys, M. Beranek, K. Hamakova, J. Kremlacek, A. Malkova, T. Svadlakova, J. Krejsek, V. Palicka, V. Rehacek, L. Kotingova, L. Borska
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- Biomarkers MeSH
- C-Reactive Protein analysis MeSH
- Chemokines blood MeSH
- Adult MeSH
- alpha-2-HS-Glycoprotein analysis MeSH
- Body Mass Index MeSH
- Middle Aged MeSH
- Humans MeSH
- Osteopontin blood MeSH
- Psoriasis complications MeSH
- Heart Disease Risk Factors * MeSH
- Case-Control Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.
Clinic of Dermal and Venereal Diseases University Hospital Hradec Kralove Czech Republic
Transfusion Center University Hospital Hradec Kralove Czech Republic
References provided by Crossref.org
Literatura
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- $a The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.
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