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Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface
E. Švecová, V. Ostatná, L. Fojt, M. Hermannová, V. Velebný, F. Ondreáš
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
- Publikační typ
- časopisecké články MeSH
This work reveals the growing potential of novel electrochemical methods that are applicable for polysaccharides. It was shown for the first time that the molecules of hyaluronic acid (HA) exhibit electrochemical response using phase-sensitive alternating current (AC) voltammetry in phase-out mode. Adsorption and desorption processes of HA fragments at a charged interface of mercury electrode were observed in buffered HA solutions. Electrostatic and hydrophobic manners of interactions were distinguished for native hyaluronan fragments in a wide electric potential range. The AC voltammetry response depended on the temperature, concentration, and length of HA chains. Results of this work open possibilities for further structural characterization of widely used HA fragments and understanding manners of interactions with charged hydrophobic surfaces that could be useful in the future for understanding HA interactions at biological levels.
Citace poskytuje Crossref.org
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- $a Švecová, Eliška $u Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic. Electronic address: Eliska.Svecova@contipro.com
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- $a Adsorption/desorption behavior of hyaluronic acid fragments at charged hydrophobic surface / $c E. Švecová, V. Ostatná, L. Fojt, M. Hermannová, V. Velebný, F. Ondreáš
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- $a This work reveals the growing potential of novel electrochemical methods that are applicable for polysaccharides. It was shown for the first time that the molecules of hyaluronic acid (HA) exhibit electrochemical response using phase-sensitive alternating current (AC) voltammetry in phase-out mode. Adsorption and desorption processes of HA fragments at a charged interface of mercury electrode were observed in buffered HA solutions. Electrostatic and hydrophobic manners of interactions were distinguished for native hyaluronan fragments in a wide electric potential range. The AC voltammetry response depended on the temperature, concentration, and length of HA chains. Results of this work open possibilities for further structural characterization of widely used HA fragments and understanding manners of interactions with charged hydrophobic surfaces that could be useful in the future for understanding HA interactions at biological levels.
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- $a Ostatná, Veronika $u Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. i., Královopolská 135, 612 65 Brno, Czech Republic. Electronic address: ostatna@ibp.cz
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- $a Fojt, Lukáš $u Institute of Biophysics, Academy of Sciences of the Czech Republic, v. v. i., Královopolská 135, 612 65 Brno, Czech Republic. Electronic address: fojt@ibp.cz
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- $a Ondreáš, František $u Contipro a.s., Dolní Dobrouč 401, 561 02 Dolní Dobrouč, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkyňova 656/123, 612 00 Brno, Czech Republic. Electronic address: Frantisek.Ondreas@contipro.com
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