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The use of Faecal Microbiota Transplantation (FMT) in Europe: A Europe-wide survey
SMD. Baunwall, EM. Terveer, JF. Dahlerup, C. Erikstrup, P. Arkkila, MJ. Vehreschild, G. Ianiro, A. Gasbarrini, H. Sokol, PK. Kump, R. Satokari, D. De Looze, S. Vermeire, R. Nakov, J. Brezina, M. Helms, J. Kjeldsen, AA. Rode, SJ. Kousgaard, L....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2021
PubMed Central
od 2021
ROAD: Directory of Open Access Scholarly Resources
od 2020
- Publikační typ
- časopisecké články MeSH
Background: Faecal microbiota transplantation (FMT) is an emerging treatment modality, but its current clinical use and organisation are unknown. We aimed to describe the clinical use, conduct, and potential for FMT in Europe. Methods: We invited all hospital-based FMT centres within the European Council member states to answer a web-based questionnaire covering their clinical activities, organisation, and regulation of FMT in 2019. Responders were identified from trials registered at clinicaltrials.gov and from the United European Gastroenterology (UEG) working group for stool banking and FMT. Findings: In 2019, 31 FMT centres from 17 countries reported a total of 1,874 (median 25, quartile 10-64) FMT procedures; 1,077 (57%) with Clostridioides difficile infection (CDI) as indication, 791 (42%) with experimental indications, and 6 (0•3%) unaccounted for. Adjusted to population size, 0•257 per 100,000 population received FMT for CDI and 0•189 per 100,000 population for experimental indications. With estimated 12,400 (6,100-28,500) annual cases of multiple, recurrent CDI and indication for FMT in Europe, the current European FMT activity covers approximately 10% of the patients with indication. The participating centres demonstrated high safety standards and adherence to international consensus guidelines. Formal or informal regulation from health authorities was present at 21 (68%) centres. Interpretation: FMT is a widespread routine treatment for multiple, recurrent CDI and an experimental treatment. Embedded within hospital settings, FMT centres operate with high standards across Europe to provide safe FMT. A significant gap in FMT coverage suggests the need to raise clinical awareness and increase the FMT activity in Europe by at least 10-fold to meet the true, indicated need. Funding: NordForsk under the Nordic Council and Innovation Fund Denmark (j.no. 8056-00006B).
Clinic of Gastroenterology Tsaritsa Yoanna University Hospital Sofia Bulgaria
Department 1 of Internal Medicine University of Cologne Cologne Germany
Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark
Department of Clinical Research University of Southern Denmark Odense Denmark
Department of Gastroenterology Ghent University Hospital Ghent Belgium
Department of Gastroenterology Haaglanden Medical Center The Hague the Netherlands
Department of Gastroenterology Helsinki University Hospital and Helsinki University Helsinki Finland
Department of Gastrointestinal Surgery Aalborg University Hospital Aalborg Denmark
Department of Infectious Diseases Copenhagen University Hospital Hvidovre Denmark
Department of Internal Medicine 4 Jena University Hospital Jena Germany
Department of Internal Medicine and Digestive Diseases IRD Toulouse 3 University Toulouse France
Department of Medical Microbiology Leiden University Medical Center Leiden the Netherlands
Department of Medicine Zealand University Hospital Køge Denmark
Department of Transplantation Medicine Oslo University Hospital Oslo Norway
Digestive Disease Center CEMAD Fondazione Policlinico Universitario Gemelli IRCCS Rome Italy
Division of Clinical Microbiology Linköping University Hospital Linköping Sweden
Division of Gastroenterology and Hepatology Medical University of Graz Graz Austria
ESCMID Study Group for Host and Microbiota Interaction Basel Switzerland
French Group of Faecal Microbiota Transplantation Paris France
Gastroenterology Department Centre Hospitalier de Thiers Thiers France
German Centre for Infection Research Partner site Bonn Cologne Germany
Human Microbiome Research Program Faculty of Medicine University of Helsinki Helsinki Finland
INRA UMR1319 Micalis AgroParisTech Jouy en Josas France
Institute of Health and Society University of Oslo Oslo Norway
National Institute for Public Health and the Environment Bilthoven the Netherlands
Netherlands Donor Feces Bank Leiden University Medical Center Leiden the Netherlands
Servicio de Gastroenterología y Hepatología Hospital Universitario Ramón y Cajal Madrid Spain
Citace poskytuje Crossref.org
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