Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals

L. Kraftova, M. Finianos, V. Studentova, K. Chudejova, V. Jakubu, H. Zemlickova, CC. Papagiannitsis, I. Bitar, J. Hrabak

. 2021 ; 11 (1) : 15732. [pub] 20210803

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22003959

The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of blaKPC-carrying plasmids; 19 out of 25 blaKPC-carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining blaKPC-carrying plasmids were multireplicon, while one plasmid couldn't be typed. Additionally, phylogenetic analysis confirmed the spread of blaKPC-carrying plasmids among different clones of diverse Enterobacterales species. Our findings demonstrated that the increased prevalence of KPC-producing isolates was due to plasmids spreading among different species. In some districts, the local dissemination of IncR and IncN plasmids was observed. Additionally, the ongoing evolution of blaKPC-carrying plasmids, through genetic rearrangements, favours the preservation and further dissemination of these mobile genetic elements. Therefore, the situation should be monitored, and immediate infection control should be implemented in hospitals reporting KPC-producing strains.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22003959
003      
CZ-PrNML
005      
20220127145704.0
007      
ta
008      
220113s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-021-95285-z $2 doi
035    __
$a (PubMed)34344951
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Kraftova, Lucie $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic
245    10
$a Evidence of an epidemic spread of KPC-producing Enterobacterales in Czech hospitals / $c L. Kraftova, M. Finianos, V. Studentova, K. Chudejova, V. Jakubu, H. Zemlickova, CC. Papagiannitsis, I. Bitar, J. Hrabak
520    9_
$a The aim of the present study is to describe the ongoing spread of the KPC-producing strains, which is evolving to an epidemic in Czech hospitals. During the period of 2018-2019, a total of 108 KPC-producing Enterobacterales were recovered from 20 hospitals. Analysis of long-read sequencing data revealed the presence of several types of blaKPC-carrying plasmids; 19 out of 25 blaKPC-carrying plasmids could be assigned to R (n = 12), N (n = 5), C (n = 1) and P6 (n = 1) incompatibility (Inc) groups. Five of the remaining blaKPC-carrying plasmids were multireplicon, while one plasmid couldn't be typed. Additionally, phylogenetic analysis confirmed the spread of blaKPC-carrying plasmids among different clones of diverse Enterobacterales species. Our findings demonstrated that the increased prevalence of KPC-producing isolates was due to plasmids spreading among different species. In some districts, the local dissemination of IncR and IncN plasmids was observed. Additionally, the ongoing evolution of blaKPC-carrying plasmids, through genetic rearrangements, favours the preservation and further dissemination of these mobile genetic elements. Therefore, the situation should be monitored, and immediate infection control should be implemented in hospitals reporting KPC-producing strains.
650    _2
$a antibakteriální látky $x farmakologie $7 D000900
650    _2
$a bakteriální proteiny $x genetika $x metabolismus $7 D001426
650    12
$a bakteriální léková rezistence $7 D024881
650    _2
$a epidemie $7 D058872
650    _2
$a nemocnice $x statistika a číselné údaje $7 D006761
650    _2
$a lidé $7 D006801
650    _2
$a infekce bakteriemi rodu Klebsiella $x epidemiologie $x mikrobiologie $7 D007710
650    _2
$a Klebsiella pneumoniae $x izolace a purifikace $x metabolismus $7 D007711
650    _2
$a beta-laktamasy $x metabolismus $7 D001618
651    _2
$a Česká republika $x epidemiologie $7 D018153
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Finianos, Marc $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic
700    1_
$a Studentova, Vendula $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic
700    1_
$a Chudejova, Katerina $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic
700    1_
$a Jakubu, Vladislav $u National Reference Laboratory for Antibiotics, National Institute of Public Health, Pilsen, Czech Republic $u Department of Microbiology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady and National Institute of Public Health, Prague, Czech Republic
700    1_
$a Zemlickova, Helena $u National Reference Laboratory for Antibiotics, National Institute of Public Health, Pilsen, Czech Republic $u Department of Microbiology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady and National Institute of Public Health, Prague, Czech Republic
700    1_
$a Papagiannitsis, Costas C $u Department of Microbiology, University Hospital of Larissa, Larissa, Greece. c.papagiannitsis@gmail.com
700    1_
$a Bitar, Ibrahim $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic. ibrahimbitar5@gmail.com $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic. ibrahimbitar5@gmail.com
700    1_
$a Hrabak, Jaroslav $u Department of Microbiology, Faculty of Medicine, and University Hospital in Pilsen, Charles University, Pilsen, Czech Republic $u Biomedical Center, Faculty of Medicine, Charles University, Pilsen, Czech Republic
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 11, č. 1 (2021), s. 15732
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34344951 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20220127145700 $b ABA008
999    __
$a ok $b bmc $g 1751424 $s 1155108
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 11 $c 1 $d 15732 $e 20210803 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
LZP    __
$a Pubmed-20220113

Najít záznam

Citační ukazatele

Možnosti archivace