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Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies

LE. Monfoulet, T. Ruskovska, V. Ajdžanović, J. Havlik, D. Vauzour, B. Bayram, I. Krga, KF. Corral-Jara, E. Kistanova, D. Abadjieva, M. Massaro, E. Scoditti, E. Deligiannidou, C. Kontogiorgis, A. Arola-Arnal, EM. van Schothorst, C. Morand, D. Milenkovic

. 2021 ; 65 (16) : e2100227. [pub] 20210702

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, práce podpořená grantem, systematický přehled

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004024

SCOPE: Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS: To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION: This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.

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$a SCOPE: Flavanols are important polyphenols of the human diet with extensive demonstrations of their beneficial effects on cardiometabolic health. They contribute to preserve health acting on a large range of cellular processes. The underlying mechanisms of action of flavanols are not fully understood but involve a nutrigenomic regulation. METHODS AND RESULTS: To further capture how the intake of dietary flavanols results in the modulation of gene expression, nutrigenomics data in response to dietary flavanols obtained from animal models of cardiometabolic diseases have been collected and submitted to a bioinformatics analysis. This systematic analysis shows that dietary flavanols modulate a large range of genes mainly involved in endocrine function, fatty acid metabolism, and inflammation. Several regulators of the gene expression have been predicted and include transcription factors, miRNAs and epigenetic factors. CONCLUSION: This review highlights the complex and multilevel action of dietary flavanols contributing to their strong potential to preserve cardiometabolic health. The identification of the potential molecular mediators and of the flavanol metabolites driving the nutrigenomic response in the target organs is still a pending question which the answer will contribute to optimize the beneficial health effects of dietary bioactives.
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$a Ruskovska, Tatjana $u Faculty of Medical Sciences, Goce Delcev University, Stip, North Macedonia
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$a Havlik, Jaroslav $u Department of Food Science, Czech University of Life Sciences Prague, Prague 6, Suchdol, Czech Republic
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$a Vauzour, David $u Department of Nutrition and Preventive Medicine, Norwich Medical School, University of East Anglia, Norwich, NR4 7TJ, UK
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$a Bayram, Banu $u Department of Nutrition and Dietetics, University of Health Sciences, Istanbul, Turkey
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$a Krga, Irena $u Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, F-63000, France $u Centre of Excellence in Nutrition and Metabolism Research, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
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$a Corral-Jara, Karla-Fabiola $u Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, F-63000, France
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$a Kistanova, Elena $u Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia, Bulgaria
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$a Massaro, Marika $u National Research Council (CNR) Institute of Clinical Physiology, Lecce, Italy
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$a Scoditti, Egeria $u National Research Council (CNR) Institute of Clinical Physiology, Lecce, Italy
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$a Deligiannidou, Eirini $u Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Alexandroupolis, 68100, Greece
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$a Kontogiorgis, Christos $u Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Alexandroupolis, 68100, Greece
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$a Arola-Arnal, Anna $u Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Nutrigenomics Research Group, Tarragona, 43007, Spain
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$a van Schothorst, Evert M $u Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands
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$a Morand, Christine $u Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, F-63000, France
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$a Milenkovic, Dragan $u Université Clermont Auvergne, INRAE, UNH, Clermont-Ferrand, F-63000, France $u Department of Internal Medicine, Division of Cardiovascular Medicine, School of Medicine, University of California Davis, Davis, California, 95616, USA
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