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A cellular and spatial map of the choroid plexus across brain ventricles and ages

N. Dani, RH. Herbst, C. McCabe, GS. Green, K. Kaiser, JP. Head, J. Cui, FB. Shipley, A. Jang, D. Dionne, L. Nguyen, C. Rodman, SJ. Riesenfeld, J. Prochazka, M. Prochazkova, R. Sedlacek, F. Zhang, V. Bryja, O. Rozenblatt-Rosen, N. Habib, A. Regev,...

. 2021 ; 184 (11) : 3056-3074.e21. [pub] 20210430

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004314

Grantová podpora
R01 NS088566 NINDS NIH HHS - United States
T32 HL110852 NHLBI NIH HHS - United States
U54 HD090255 NICHD NIH HHS - United States

The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1β (IL-1β) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.

Citace poskytuje Crossref.org

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$a The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1β (IL-1β) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.
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$a Herbst, Rebecca H $u Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
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$a McCabe, Cristin $u Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
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$a Green, Gilad S $u Edmond and Lily Safra Center for Brain Sciences, Hebrew University of Jerusalem, Jerusalem 9190401, Israel
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$a Kaiser, Karol $u Department of Experimental Biology, Faculty of Science, Masaryk University, Brno 611 37, Czech Republic
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$a Prochazka, Jan $u Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, Prague 142 20, Czech Republic
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$a Sedlacek, Radislav $u Czech Centre for Phenogenomics and Laboratory of Transgenic Models of Diseases, Institute of Molecular Genetics of the CAS, Prague 142 20, Czech Republic
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$a Zhang, Feng $u Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
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$a Bryja, Vitezslav $u Department of Experimental Biology, Faculty of Science, Masaryk University, Brno 611 37, Czech Republic
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