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Consensus guidelines for botulinum toxin therapy: general algorithms and dosing tables for dystonia and spasticity
D. Dressler, MC. Altavista, E. Altenmueller, R. Bhidayasiri, S. Bohlega, P. Chana, TM. Chung, C. Colosimo, K. Fheodoroff, PJ. Garcia-Ruiz, B. Jeon, L. Jin, P. Kanovsky, I. Milanov, F. Micheli, O. Orlova, S. Pandey, Z. Pirtosek, M. Relja, R....
Language English Country Austria
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Algorithms MeSH
- Botulinum Toxins, Type A * MeSH
- Botulinum Toxins * MeSH
- Dystonic Disorders * drug therapy MeSH
- Dystonia * drug therapy MeSH
- Humans MeSH
- Muscle Spasticity drug therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Botulinum toxin (BT) therapy is a complex and highly individualised therapy defined by treatment algorithms and injection schemes describing its target muscles and their dosing. Various consensus guidelines have tried to standardise and to improve BT therapy. We wanted to update and improve consensus guidelines by: (1) Acknowledging recent advances of treatment algorithms. (2) Basing dosing tables on statistical analyses of real-life treatment data of 1831 BT injections in 36 different target muscles in 420 dystonia patients and 1593 BT injections in 31 different target muscles in 240 spasticity patients. (3) Providing more detailed dosing data including typical doses, dose variabilities, and dosing limits. (4) Including total doses and target muscle selections for typical clinical entities thus adapting dosing to different aetiologies and pathophysiologies. (5) In addition, providing a brief and concise review of the clinical entity treated together with general principles of its BT therapy. For this, we collaborated with IAB-Interdisciplinary Working Group for Movement Disorders which invited an international panel of experts for the support.
Clinic 'Cecil Plus' Moscow Russia
Department of Neurology A C O San Filippo Neri Rome Italy
Department of Neurology Fundacion Jimenez Diaz Madrid Spain
Department of Neurology Iran University of Medical Sciences Tehran Iran
Department of Neurology King Faisal Specialist Hospital Riyyad Kingdom of Saudi Arabia
Department of Neurology Ljubljana University Ljubljana Slovenia
Department of Neurology Medical University of Sofia Sofia Bulgaria
Department of Neurology Palacky University Olomouc Czech Republic
Department of Neurology Peking Union Medical College Beijing China
Department of Neurology Rostock University Rostock Germany
Department of Neurology Santa Maria University Hospital Terni Italy
Department of Neurology Seoul National University Seoul Republic of Korea
Department of Neurology Tongji University School of Medicine Shanghai China
Department of Neurology University de Santiago de Chile Santiago de Chile Chile
Department of Neurology University of Monterrey Monterrey Nueva Leon Mexico
Department of Neurology University of Santo Tomas Manila Philippines
Department of Neurology University of Zagreb Zagreb Croatia
Gailtal Klinik Hermagor Austria
IAB Interdisciplinary Working Group for Movement Disorders Hamburg Germany
References provided by Crossref.org
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