Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

K. Mareckova, A. Miles, L. Andryskova, M. Brazdil, YS. Nikolova

. 2020 ; 41 (17) : 4866-4875. [pub] 20201003

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22004772

Grantová podpora
European Union: Marie Curie Intra-European Fellowship for Career Development FP7-IEF-2013) Ministry of Education, Youth and Sports of the Czech Republic: CEITEC 2020, LQ1601, LM201812, LM2015062, LM2018129. CAMH Foundation: Koerner New Scientist Award, Discovery Fund Postdoctoral Fellowship.

Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p < .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f2 = 0.10-0.19, p < .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r = 0.399, p = .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22004772
003      
CZ-PrNML
005      
20230602102324.0
007      
ta
008      
220113s2020 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1002/hbm.25163 $2 doi
035    __
$a (PubMed)33010202
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Mareckova, Klara $u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada $u Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
245    10
$a Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood / $c K. Mareckova, A. Miles, L. Andryskova, M. Brazdil, YS. Nikolova
520    9_
$a Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f2 = 0.19-0.38, p < .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f2 = 0.10-0.19, p < .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r = 0.399, p = .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.
650    _2
$a dospělí $7 D000328
650    12
$a afektivní symptomy $x diagnostické zobrazování $x etiologie $x patologie $x patofyziologie $7 D000342
650    12
$a mozková kůra $x diagnostické zobrazování $x patologie $x patofyziologie $7 D002540
650    _2
$a emoční regulace $x fyziologie $7 D000080103
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a kojenec $7 D007223
650    _2
$a novorozenec $7 D007231
650    _2
$a longitudinální studie $7 D008137
650    _2
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a poporodní období $7 D049590
650    _2
$a těhotenství $7 D011247
650    12
$a zpožděný efekt prenatální expozice $x diagnostické zobrazování $x etiologie $x patologie $x patofyziologie $7 D011297
650    _2
$a psychický stres $x komplikace $7 D013315
650    _2
$a mladý dospělý $7 D055815
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Miles, Amy $u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada
700    1_
$a Andrýsková, Lenka $u RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic $7 xx0302202
700    1_
$a Brazdil, Milan $u Brain and Mind Research, Central European Institute of Technology, Masaryk University, Brno, Czech Republic
700    1_
$a Nikolova, Yuliya S $u Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Canada $u Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
773    0_
$w MED00002066 $t Human brain mapping $x 1097-0193 $g Roč. 41, č. 17 (2020), s. 4866-4875
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33010202 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220113 $b ABA008
991    __
$a 20230602102316 $b ABA008
999    __
$a ok $b bmc $g 1752070 $s 1155921
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 41 $c 17 $d 4866-4875 $e 20201003 $i 1097-0193 $m Human brain mapping $n Hum Brain Mapp $x MED00002066
GRA    __
$p European Union: Marie Curie Intra-European Fellowship for Career Development FP7-IEF-2013) Ministry of Education, Youth and Sports of the Czech Republic: CEITEC 2020, LQ1601, LM201812, LM2015062, LM2018129. CAMH Foundation: Koerner New Scientist Award, Discovery Fund Postdoctoral Fellowship.
LZP    __
$a Pubmed-20220113
Zpět

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace