Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Stanovení hladiny glukózy, laktátu, NGAL a KEB ve výpotku u infekcí TEP kolen a kyčlí
[Glucose, Lactate, NGAL and Coefficient of Energy Balance in Synovial Fluid in Patients with Hip and Knee Prosthetic Joint Infection]

M. Svoboda, J. Gallo, J. Zapletalová, J. Prošková, J. Juráňová, Y. Lovečková

. 2022 ; 89 (1) : 16-26. [pub] 20220221

Jazyk čeština Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22007943

PURPOSE OF THE STUDY Laboratory methods are central to prosthetic joint infection (PJI) diagnosis. Most research teams focus on detection of specific inflammatory markers, causative pathogens, or on assessment of the tissue response. This study sought to determine the optimal cut-off values and diagnostic performance of selected synovial markers in relation to the diagnosis of hip or knee PJI. The studied markers were synovial level of glucose, lactate, coefficient of energy balance (CEB) and NGAL (neutrophil gelatinase-associated lipocalin). MATERIAL AND METHODS This prospective study includes 89 patients who underwent revision total knee or hip arthroplasty for septic or aseptic reasons in the period from 2014 to 2017. Among these 89 patients, there are 2 cases of prosthetic hip infection, 22 cases of prosthetic knee infection, 31 aseptic revision total hip arthroplasties and 34 aseptic revision total knee arthroplasties. The diagnostic characteristics of the studied methods were set in relation to the reference standard, the 2013 MSIS (Musculoskeletal Infection Society) criteria. The cut-off values were calculated using the ROC (receiver operating characteristic curve) analysis. RESULTS The synovial glucose test is considered positive if the glucose level drops below 2.65 mmol/L. The area under the curve is 0.813, sensitivity 75.0%, specificity 83.1%. The synovial lactate test is considered positive if lactate level rises above 8.87 mmol/L. The area under the curve is 0.882, sensitivity 70.8%, specificity 95.4%. Synovial NGAL is considered positive if its level exceeds 998 μg/L. The area under the curve is 1.000, sensitivity 100.0%, specificity 100.0%. CEB is considered positive if its value is lower than +4.665. The area under the curve is 0.883, sensitivity 91.7% and specificity 69.8%. Combining of these tests with other synovial markers does not improve the diagnostic performance of the studied tests. CONCLUSIONS The glucose and lactate levels and CEB undoubtedly reflect the presence of an inflammatory process in a prosthetic joint. However, the diagnostic characteristics of these tests are not better than those of other modern diagnostic techniques. As opposed to these tests, synovial NGAL shows excellent diagnostic performance. Nonetheless, the potential of this method shall be verified on larger cohorts of patients. Key words: prosthetic joint infection, periprosthetic infection, total knee arthroplasty, total hip arthroplasty, diagnosis, glucose, lactate, CEB, NGAL.

Glucose, Lactate, NGAL and Coefficient of Energy Balance in Synovial Fluid in Patients with Hip and Knee Prosthetic Joint Infection

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc22007943
003      
CZ-PrNML
005      
20220323100947.0
007      
ta
008      
220309s2022 xr d f 000 0|cze||
009      
AR
024    7_
$a 10.55095/achot2022/002 $2 doi
035    __
$a (PubMed)35247240
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a cze $b eng
044    __
$a xr
100    1_
$a Svoboda, Michal $7 xx0270821 $u Ortopedická klinika Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého v Olomouci
245    10
$a Stanovení hladiny glukózy, laktátu, NGAL a KEB ve výpotku u infekcí TEP kolen a kyčlí / $c M. Svoboda, J. Gallo, J. Zapletalová, J. Prošková, J. Juráňová, Y. Lovečková
246    31
$a Glucose, Lactate, NGAL and Coefficient of Energy Balance in Synovial Fluid in Patients with Hip and Knee Prosthetic Joint Infection
504    __
$a Literatura
520    9_
$a PURPOSE OF THE STUDY Laboratory methods are central to prosthetic joint infection (PJI) diagnosis. Most research teams focus on detection of specific inflammatory markers, causative pathogens, or on assessment of the tissue response. This study sought to determine the optimal cut-off values and diagnostic performance of selected synovial markers in relation to the diagnosis of hip or knee PJI. The studied markers were synovial level of glucose, lactate, coefficient of energy balance (CEB) and NGAL (neutrophil gelatinase-associated lipocalin). MATERIAL AND METHODS This prospective study includes 89 patients who underwent revision total knee or hip arthroplasty for septic or aseptic reasons in the period from 2014 to 2017. Among these 89 patients, there are 2 cases of prosthetic hip infection, 22 cases of prosthetic knee infection, 31 aseptic revision total hip arthroplasties and 34 aseptic revision total knee arthroplasties. The diagnostic characteristics of the studied methods were set in relation to the reference standard, the 2013 MSIS (Musculoskeletal Infection Society) criteria. The cut-off values were calculated using the ROC (receiver operating characteristic curve) analysis. RESULTS The synovial glucose test is considered positive if the glucose level drops below 2.65 mmol/L. The area under the curve is 0.813, sensitivity 75.0%, specificity 83.1%. The synovial lactate test is considered positive if lactate level rises above 8.87 mmol/L. The area under the curve is 0.882, sensitivity 70.8%, specificity 95.4%. Synovial NGAL is considered positive if its level exceeds 998 μg/L. The area under the curve is 1.000, sensitivity 100.0%, specificity 100.0%. CEB is considered positive if its value is lower than +4.665. The area under the curve is 0.883, sensitivity 91.7% and specificity 69.8%. Combining of these tests with other synovial markers does not improve the diagnostic performance of the studied tests. CONCLUSIONS The glucose and lactate levels and CEB undoubtedly reflect the presence of an inflammatory process in a prosthetic joint. However, the diagnostic characteristics of these tests are not better than those of other modern diagnostic techniques. As opposed to these tests, synovial NGAL shows excellent diagnostic performance. Nonetheless, the potential of this method shall be verified on larger cohorts of patients. Key words: prosthetic joint infection, periprosthetic infection, total knee arthroplasty, total hip arthroplasty, diagnosis, glucose, lactate, CEB, NGAL.
650    12
$a náhrada kyčelního kloubu $x škodlivé účinky $7 D019644
650    12
$a totální endoprotéza kolene $x škodlivé účinky $7 D019645
650    _2
$a biologické markery $x analýza $7 D015415
650    _2
$a C-reaktivní protein $x analýza $7 D002097
650    _2
$a glukosa $7 D005947
650    _2
$a lidé $7 D006801
650    12
$a protézy kolene $x škodlivé účinky $7 D007720
650    _2
$a kyselina mléčná $7 D019344
650    _2
$a lipokalin-2 $x analýza $7 D000071068
650    _2
$a prospektivní studie $7 D011446
650    12
$a infekce spojené s protézou $x diagnóza $x etiologie $7 D016459
650    _2
$a senzitivita a specificita $7 D012680
650    _2
$a synoviální tekutina $x chemie $7 D013582
655    _2
$a časopisecké články $7 D016428
700    1_
$a Gallo, Jiří $7 xx0019005 $u Ortopedická klinika Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého v Olomouci
700    1_
$a Zapletalová, Jana $7 xx0111614 $u Ústav lékařské biofyziky Lékařské fakulty Univerzity Palackého v Olomouci
700    1_
$a Prošková, Jitka $7 xx0230492 $u Oddělení klinické biochemie Fakultní nemocnice Olomouc
700    1_
$a Juráňová, Jarmila $7 xx0112984 $u Hematoonkologická klinika Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého v Olomouci
700    1_
$a Lovečková, Yvona, $d 1965- $7 xx0073944 $u Ústav mikrobiologie Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého v Olomouci
773    0_
$w MED00011021 $t Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca $x 0001-5415 $g Roč. 89, č. 1 (2022), s. 16-26
856    41
$u https://achot.cz/pdfs/ach/2022/01/02.pdf $y plný text volně přístupný
910    __
$a ABA008 $b A 8 $c 507 $y p $z 0
990    __
$a 20220309 $b ABA008
991    __
$a 20220323100943 $b ABA008
999    __
$a ok $b bmc $g 1773073 $s 1159136
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 89 $c 1 $d 16-26 $e 20220221 $i 0001-5415 $m Acta chirurgiae orthopaedicae et traumatologiae Čechoslovaca $n Acta chir. orthop. traumatol. Čechoslovaca $x MED00011021
LZP    __
$b NLK118 $a Pubmed-20220309

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace