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Evaluation of Second-Generation Lipophosphonoxins as Antimicrobial Additives in Bone Cement

E. Zborníková, J. Gallo, R. Večeřová, K. Bogdanová, M. Kolář, D. Vítovská, DD. Do Pham, O. Pačes, V. Mojr, H. Šanderová, J. Ulrichová, A. Galandáková, D. Čadek, Z. Hrdlička, L. Krásný, D. Rejman

. 2020 ; 5 (7) : 3165-3171. [pub] 20200212

Language English Country United States

Document type Journal Article, Research Support, Non-U.S. Gov't, Evaluation Study

Persistent link   https://www.medvik.cz/link/bmc22008252

Grant support
NV17-29680A MZ0 CEP Register

Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period. Here, we investigate the potential of novel antibacterial compounds-second-generation lipophosphonoxins (LPPOs II)-as additives to surgical bone cements. We demonstrate (i) excellent thermostability of LPPOs II, which is essential to withstand elevated temperatures during exothermic cement polymerization; (ii) unchanged tensile strength and elongation at the break properties of the composite cements containing LPPOs II compared to cements without additives; (iii) convenient elution kinetics on the order of days; and (iv) the strong antibiofilm activity of the LPPO II-loaded cements even against bacteria resistant to the medicinally utilized antibiotic, gentamicin. Thus, LPPOs II display promising potential as antimicrobial additives to surgical bone cements.

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$a Successful surgeries involving orthopedic implants depend on the avoidance of biofilm development on the implant surface during the early postoperative period. Here, we investigate the potential of novel antibacterial compounds-second-generation lipophosphonoxins (LPPOs II)-as additives to surgical bone cements. We demonstrate (i) excellent thermostability of LPPOs II, which is essential to withstand elevated temperatures during exothermic cement polymerization; (ii) unchanged tensile strength and elongation at the break properties of the composite cements containing LPPOs II compared to cements without additives; (iii) convenient elution kinetics on the order of days; and (iv) the strong antibiofilm activity of the LPPO II-loaded cements even against bacteria resistant to the medicinally utilized antibiotic, gentamicin. Thus, LPPOs II display promising potential as antimicrobial additives to surgical bone cements.
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