• Something wrong with this record ?

Association of polymorphisms in endothelin-1 and endothelin receptor a genes with vasovagal syncope

Z. Lazurova, V. Habalova, P. Mitro

. 2022 ; 71 (1) : 93-101. [pub] 20220119

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc22009490

The endothelin system may play a role in the pathogenesis of vasovagal syncope (VVS) because it is implicated in blood pressure regulation. We hypothesized that endothelin-related genetic polymorphisms might modulate susceptibility to VVS. This study aimed to evaluate the possible influence of endothelin-1 (EDN1) and endothelin receptor A (EDNRA) gene variants on the occurrence of tilt-induced VVS and autonomic nervous system activity during the head-up tilt test (HUT). Results were expressed as mean +/- SEM. In 254 patients with recurrent syncope (age 45.33+/-1.22 years, 94 males, 160 females), heart rate variability (HRV) was measured during HUT. EDN1 rs5370 G>T and EDNRA rs5333 T>C gene polymorphisms were assessed using high-resolution melting analysis. There was no statistically significant association between polymorphisms EDN1 rs5370 and EDNRA rs5333 and positivity of HUT or hemodynamic types of VVS. Patients with GT or TT genotypes at the rs5370 locus of the EDN1 had significantly higher values of high-frequency (HF) and the standard deviation of the average NN intervals at the time of the syncope, and they tended to have lower low-frequency (LF) and LF/HF ratio when compared to homozygotes (GG). No statistically significant differences were found in HRV parameters concerning the EDNRA rs5333 genotypes. Our findings suggest the potential role of EDN1 rs5370 variants in regulating autonomic nervous activity and pathogenesis of VVS.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22009490
003      
CZ-PrNML
005      
20230331101509.0
007      
ta
008      
220419s2022 xr f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934689 $2 doi
035    __
$a (PubMed)35043642
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Lazurova, Zora $u Fourth Department of Internal Medicine, Medical Faculty of University of P.J. Safarik, Kosice, Slovak, Republic $u First Department of Cardiology, Medical Faculty of University of P.J. Safarik, Kosice, Slovak Republic
245    10
$a Association of polymorphisms in endothelin-1 and endothelin receptor a genes with vasovagal syncope / $c Z. Lazurova, V. Habalova, P. Mitro
520    9_
$a The endothelin system may play a role in the pathogenesis of vasovagal syncope (VVS) because it is implicated in blood pressure regulation. We hypothesized that endothelin-related genetic polymorphisms might modulate susceptibility to VVS. This study aimed to evaluate the possible influence of endothelin-1 (EDN1) and endothelin receptor A (EDNRA) gene variants on the occurrence of tilt-induced VVS and autonomic nervous system activity during the head-up tilt test (HUT). Results were expressed as mean +/- SEM. In 254 patients with recurrent syncope (age 45.33+/-1.22 years, 94 males, 160 females), heart rate variability (HRV) was measured during HUT. EDN1 rs5370 G>T and EDNRA rs5333 T>C gene polymorphisms were assessed using high-resolution melting analysis. There was no statistically significant association between polymorphisms EDN1 rs5370 and EDNRA rs5333 and positivity of HUT or hemodynamic types of VVS. Patients with GT or TT genotypes at the rs5370 locus of the EDN1 had significantly higher values of high-frequency (HF) and the standard deviation of the average NN intervals at the time of the syncope, and they tended to have lower low-frequency (LF) and LF/HF ratio when compared to homozygotes (GG). No statistically significant differences were found in HRV parameters concerning the EDNRA rs5333 genotypes. Our findings suggest the potential role of EDN1 rs5370 variants in regulating autonomic nervous activity and pathogenesis of VVS.
650    _2
$a dospělí $7 D000328
650    12
$a endotelin-1 $x genetika $7 D019332
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a srdeční frekvence $x genetika $7 D006339
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a polymorfismus genetický $x genetika $7 D011110
650    _2
$a receptor endotelinu A $x genetika $7 D044022
650    12
$a vazovagální synkopa $x diagnóza $x genetika $7 D019462
650    _2
$a test na nakloněné rovině $7 D018667
655    _2
$a časopisecké články $7 D016428
700    1_
$a Habalová, Viera $7 xx0062315 $u Department of Medical Biology, Medical Faculty of University of P.J. Safarik, Kosice, Slovak Republic
700    1_
$a Mitro, Peter $7 xx0062348 $u First Department of Cardiology, Medical Faculty of University of P.J. Safarik, Kosice, Slovak Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 71, č. 1 (2022), s. 93-101
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35043642 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20220419 $b ABA008
991    __
$a 20230331101504 $b ABA008
999    __
$a ok $b bmc $g 1796998 $s 1160688
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 71 $c 1 $d 93-101 $e 20220119 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK198 $a Pubmed-20220419

Find record

Citation metrics

Archiving options