Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Biomarkers Analysis and Clinical Manifestations in Comorbid Creutzfeldt-Jakob Disease: A Retrospective Study in 215 Autopsy Cases

N. Jankovska, R. Rusina, J. Keller, J. Kukal, M. Bruzova, E. Parobkova, T. Olejar, R. Matej

. 2022 ; 10 (3) : . [pub] 20220316

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22009774

Grantová podpora
00064165 Ministry of Health
00064190 Ministry of Health
NV19-04-00090 Ministry of Health
142120 Charles University
Q35/LF3 Charles University

Creutzfeldt-Jakob disease (CJD), the most common human prion disorder, may occur as "pure" neurodegeneration with isolated prion deposits in the brain tissue; however, comorbid cases with different concomitant neurodegenerative diseases have been reported. This retrospective study examined correlations of clinical, neuropathological, molecular-genetic, immunological, and neuroimaging biomarkers in pure and comorbid CJD. A total of 215 patients have been diagnosed with CJD during the last ten years by the Czech National Center for Prion Disorder Surveillance. Data were collected from all patients with respect to diagnostic criteria for probable CJD, including clinical description, EEG, MRI, and CSF findings. A detailed neuropathological analysis uncovered that only 11.16% were "pure" CJD, while 62.79% had comorbid tauopathy, 20.47% had Alzheimer's disease, 3.26% had frontotemporal lobar degeneration, and 2.33% had synucleinopathy. The comorbid subgroup analysis revealed that tauopathy was linked to putaminal hyperintensity on MRIs, and AD mainly impacted the age of onset, hippocampal atrophy on MRIs, and beta-amyloid levels in the CSF. The retrospective data analysis found a surprisingly high proportion of comorbid neuropathologies; only 11% of cases were verified as "pure" CJD, i.e., lacking hallmarks of other neurodegenerations. Comorbid neuropathologies can impact disease manifestation and can complicate the clinical diagnosis of CJD.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22009774
003      
CZ-PrNML
005      
20220425131547.0
007      
ta
008      
220420s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/biomedicines10030680 $2 doi
035    __
$a (PubMed)35327482
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Jankovska, Nikol $u Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech Republic $1 https://orcid.org/0000000184222628
245    10
$a Biomarkers Analysis and Clinical Manifestations in Comorbid Creutzfeldt-Jakob Disease: A Retrospective Study in 215 Autopsy Cases / $c N. Jankovska, R. Rusina, J. Keller, J. Kukal, M. Bruzova, E. Parobkova, T. Olejar, R. Matej
520    9_
$a Creutzfeldt-Jakob disease (CJD), the most common human prion disorder, may occur as "pure" neurodegeneration with isolated prion deposits in the brain tissue; however, comorbid cases with different concomitant neurodegenerative diseases have been reported. This retrospective study examined correlations of clinical, neuropathological, molecular-genetic, immunological, and neuroimaging biomarkers in pure and comorbid CJD. A total of 215 patients have been diagnosed with CJD during the last ten years by the Czech National Center for Prion Disorder Surveillance. Data were collected from all patients with respect to diagnostic criteria for probable CJD, including clinical description, EEG, MRI, and CSF findings. A detailed neuropathological analysis uncovered that only 11.16% were "pure" CJD, while 62.79% had comorbid tauopathy, 20.47% had Alzheimer's disease, 3.26% had frontotemporal lobar degeneration, and 2.33% had synucleinopathy. The comorbid subgroup analysis revealed that tauopathy was linked to putaminal hyperintensity on MRIs, and AD mainly impacted the age of onset, hippocampal atrophy on MRIs, and beta-amyloid levels in the CSF. The retrospective data analysis found a surprisingly high proportion of comorbid neuropathologies; only 11% of cases were verified as "pure" CJD, i.e., lacking hallmarks of other neurodegenerations. Comorbid neuropathologies can impact disease manifestation and can complicate the clinical diagnosis of CJD.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Rusina, Robert $u Department of Neurology, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech Republic
700    1_
$a Keller, Jiri $u Department of Neurology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic $u Department of Radiology, Na Homolce Hospital, 150 00 Prague, Czech Republic $1 https://orcid.org/0000000267997840 $7 xx0145264
700    1_
$a Kukal, Jaromir $u Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, 115 19 Prague, Czech Republic
700    1_
$a Bruzova, Magdalena $u Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech Republic $1 https://orcid.org/0000000266037602
700    1_
$a Parobkova, Eva $u Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech Republic
700    1_
$a Olejar, Tomas $u Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech Republic $1 https://orcid.org/0000000207865029 $7 xx0242541
700    1_
$a Matej, Radoslav $u Department of Pathology and Molecular Medicine, Third Faculty of Medicine, Charles University and Thomayer University Hospital, 140 59 Prague, Czech Republic $u Department of Pathology, First Faculty of Medicine, Charles University and General University Hospital, 128 00 Prague, Czech Republic $u Department of Pathology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, 100 34 Prague, Czech Republic $1 https://orcid.org/0000000261526343
773    0_
$w MED00205373 $t Biomedicines $x 2227-9059 $g Roč. 10, č. 3 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35327482 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20220420 $b ABA008
991    __
$a 20220425131545 $b ABA008
999    __
$a ind $b bmc $g 1784392 $s 1160972
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 10 $c 3 $e 20220316 $i 2227-9059 $m Biomedicines $n Biomedicines $x MED00205373
GRA    __
$a 00064165 $p Ministry of Health
GRA    __
$a 00064190 $p Ministry of Health
GRA    __
$a NV19-04-00090 $p Ministry of Health
GRA    __
$a 142120 $p Charles University
GRA    __
$a Q35/LF3 $p Charles University
LZP    __
$a Pubmed-20220420

Najít záznam

Citační ukazatele

Možnosti archivace