-
Je něco špatně v tomto záznamu ?
Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 in kidney transplant recipients during pandemic
T. Reischig, M. Kacer, T. Vlas, P. Drenko, L. Kielberger, J. Machova, O. Topolcan, R. Kucera, S. Kormunda
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
FIND [CZ.02.1.01/0.0/0.0/16_019/0000787]
Ministry of Education, Youth and Sports of the Czech Republic, financed from The European Regional Development Fund
Charles University Research Fund [Progress Q39]
Lékařská Fakulta v Plzni, Univerzita Karlova
NLK
Free Medical Journals
od 2001 do 2022
Wiley Free Content
od 2001 do 2022
ROAD: Directory of Open Access Scholarly Resources
od 2001
PubMed
34860470
DOI
10.1111/ajt.16902
Knihovny.cz E-zdroje
- MeSH
- COVID-19 * epidemiologie prevence a kontrola MeSH
- incidence MeSH
- lidé MeSH
- messenger RNA MeSH
- mRNA vakcíny MeSH
- pandemie MeSH
- příjemce transplantátu MeSH
- prospektivní studie MeSH
- protilátky virové MeSH
- retrospektivní studie MeSH
- SARS-CoV-2 MeSH
- syntetické vakcíny MeSH
- transplantace ledvin * škodlivé účinky MeSH
- vakcína BNT162 MeSH
- vakcíny proti COVID-19 MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 (COVID-19). We retrospectively evaluated COVID-19 in kidney transplant recipients (n = 226) after BNT162b2 mRNA vaccine administration. The control group consisted of unvaccinated patients (n = 194) during the previous pandemic wave. We measured anti-spike protein immunoglobulin G (IgG) levels and cellular responses, using enzyme-linked immunosorbent spot assay, in a prospective cohort after vaccination (n = 31) and recovery from COVID-19 (n = 19). COVID-19 was diagnosed in 37 (16%) vaccinated and 43 (22%) unvaccinated patients. COVID-19 severity was similar in both groups, with patients exhibiting a comparable need for hospitalization (41% vs. 40%, p = 1.000) and mortality (14% vs. 9%, p = .726). Short posttransplant periods were associated with COVID-19 after vaccination (p < .001). Only 5 (16%) patients achieved positive SARS-CoV-2 IgG after vaccination, and 17 (89%, p < .001) recovered from COVID-19 (median IgG levels, 0.6 vs. 52.5 AU/ml, p < .001). A cellular response following vaccination was present in the majority (n = 22, 71%), with an increase in interleukin 2 secreting T cells (p < .001). Despite detectable T cell immunity after mRNA vaccination, kidney transplant recipients remained at a high risk of severe COVID-19. Humoral responses induced by vaccination were significantly lower than that after COVID-19.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22010810
- 003
- CZ-PrNML
- 005
- 20220629075204.0
- 007
- ta
- 008
- 220425s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/ajt.16902 $2 doi
- 035 __
- $a (PubMed)34860470
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Reischig, Tomas $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic $1 https://orcid.org/000000025404598X
- 245 10
- $a Insufficient response to mRNA SARS-CoV-2 vaccine and high incidence of severe COVID-19 in kidney transplant recipients during pandemic / $c T. Reischig, M. Kacer, T. Vlas, P. Drenko, L. Kielberger, J. Machova, O. Topolcan, R. Kucera, S. Kormunda
- 520 9_
- $a Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 (COVID-19). We retrospectively evaluated COVID-19 in kidney transplant recipients (n = 226) after BNT162b2 mRNA vaccine administration. The control group consisted of unvaccinated patients (n = 194) during the previous pande $a Severe acute respiratory syndrome coronavirus 2 SARS CoV 2 mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 COVID 19 We retrospectively evaluated COVID 19 in kidney transplant recipients n 226 after BNT162b2 mRNA vaccine administration The control group consisted of unvaccinated patients n 194 during the previous pandemic wave We me $a Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination may fail to sufficiently protect transplant recipients against coronavirus disease 2019 (COVID-19). We retrospectively evaluated COVID-19 in kidney transplant recipients (n = 226) after BNT162b2 mRNA vaccine administration. The control group consisted of unvaccinated patients (n = 194) during the previous pandemic wave. We measured anti-spike protein immunoglobulin G (IgG) levels and cellular responses, using enzyme-linked immunosorbent spot assay, in a prospective cohort after vaccination (n = 31) and recovery from COVID-19 (n = 19). COVID-19 was diagnosed in 37 (16%) vaccinated and 43 (22%) unvaccinated patients. COVID-19 severity was similar in both groups, with patients exhibiting a comparable need for hospitalization (41% vs. 40%, p = 1.000) and mortality (14% vs. 9%, p = .726). Short posttransplant periods were associated with COVID-19 after vaccination (p < .001). Only 5 (16%) patients achieved positive SARS-CoV-2 IgG after vaccination, and 17 (89%, p < .001) recovered from COVID-19 (median IgG levels, 0.6 vs. 52.5 AU/ml, p < .001). A cellular response following vaccination was present in the majority (n = 22, 71%), with an increase in interleukin 2 secreting T cells (p < .001). Despite detectable T cell immunity after mRNA vaccination, kidney transplant recipients remained at a high risk of severe COVID-19. Humoral responses induced by vaccination were significantly lower than that after COVID-19.
- 650 _2
- $a protilátky virové $7 D000914
- 650 _2
- $a vakcína BNT162 $7 D000090982
- 650 12
- $a COVID-19 $x epidemiologie $x prevence a kontrola $7 D000086382
- 650 _2
- $a vakcíny proti COVID-19 $7 D000086663
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a incidence $7 D015994
- 650 12
- $a transplantace ledvin $x škodlivé účinky $7 D016030
- 650 _2
- $a pandemie $7 D058873
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a messenger RNA $7 D012333
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a SARS-CoV-2 $7 D000086402
- 650 _2
- $a příjemce transplantátu $7 D066027
- 650 _2
- $a syntetické vakcíny $7 D014614
- 650 _2
- $a mRNA vakcíny $7 D000087503
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Kacer, Martin $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Vlas, Tomas $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic $u Department of Immunology and Allergology, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $1 https://orcid.org/0000000248356511 $7 jx20090623009
- 700 1_
- $a Drenko, Petr $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $7 xx0274393
- 700 1_
- $a Kielberger, Lukas $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic $1 https://orcid.org/0000000321494364
- 700 1_
- $a Machova, Jana $u Department of Internal Medicine I, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
- 700 1_
- $a Topolcan, Ondrej $u Department of Immunochemistry Diagnostics, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $1 https://orcid.org/000000016622390X $7 jn20000402383
- 700 1_
- $a Kucera, Radek $u Department of Immunochemistry Diagnostics, Faculty of Medicine in Pilsen, Charles University and Teaching Hospital, Pilsen, Czech Republic $1 https://orcid.org/0000000227392302 $7 jo2016919265
- 700 1_
- $a Kormunda, Stanislav $u Biomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic $u Division of Information Technologies and Statistics, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
- 773 0_
- $w MED00006447 $t American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons $x 1600-6143 $g Roč. 22, č. 3 (2022), s. 801-812
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34860470 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220629075159 $b ABA008
- 999 __
- $a ok $b bmc $g 1788771 $s 1162008
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 22 $c 3 $d 801-812 $e 20211210 $i 1600-6143 $m American journal of transplantation $n Am J Transplant $x MED00006447
- GRA __
- $a FIND [CZ.02.1.01/0.0/0.0/16_019/0000787] $p Ministry of Education, Youth and Sports of the Czech Republic, financed from The European Regional Development Fund
- GRA __
- $a Charles University Research Fund [Progress Q39] $p Lékařská Fakulta v Plzni, Univerzita Karlova
- LZP __
- $a Pubmed-20220425
