-
Something wrong with this record ?
Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease
J. Trebicka, W. Gu, V. de Ledinghen, C. Aubé, A. Krag, M. Praktiknjo, L. Castera, J. Dumortier, DJM. Bauer, M. Friedrich-Rust, S. Pol, I. Grgurevic, R. Zheng, S. Francque, H. Gottfriedovà, S. Mustapic, I. Sporea, A. Berzigotti, FE. Uschner, B....
Language English Country Great Britain
Document type Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't
NLK
ProQuest Central
from 1960-03-01 to 6 months ago
Health & Medicine (ProQuest)
from 1960-03-01 to 6 months ago
- MeSH
- Algorithms MeSH
- Chronic Disease MeSH
- Adult MeSH
- Elasticity Imaging Techniques * MeSH
- Middle Aged MeSH
- Humans MeSH
- Survival Rate MeSH
- Liver Diseases diagnosis etiology mortality MeSH
- Predictive Value of Tests MeSH
- Retrospective Studies MeSH
- ROC Curve MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVE: Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients. DESIGN: This international multicentre cohort study included a derivation ACLD patient cohort with valid two-dimensional shear wave elastography (2D-SWE) results. Clinical and laboratory parameters at baseline and during follow-up were recorded. LSM by transient elastography (TE) was also recorded if available. The primary outcome was overall mortality. The secondary outcome was the development of first/further decompensation. RESULTS: After screening 2148 patients (16 centres), 1827 patients (55 years, 62.4% men) were included in the 2D-SWE cohort, with median liver SWE (L-SWE) 11.8 kPa and a model for end stage liver disease (MELD) score of 8. Combination of MELD score and L-SWE predict independently of mortality (AUC 0.8). L-SWE cut-off at ≥20 kPa combined with MELD ≥10 could stratify the risk of mortality and first/further decompensation in ACLD patients. The 2-year mortality and decompensation rates were 36.9% and 61.8%, respectively, in the 305 (18.3%) high-risk patients (with L-SWE ≥20 kPa and MELD ≥10), while in the 944 (56.6%) low-risk patients, these were 1.1% and 3.5%, respectively. Importantly, this M10LS20 algorithm was validated by TE-based LSM and in an additional cohort of 119 patients with valid point shear SWE-LSM. CONCLUSION: The M10LS20 algorithm allows risk stratification of patients with ACLD. Patients with L-SWE ≥20 kPa and MELD ≥10 should be followed closely and receive intensified care, while patients with low risk may be managed at longer intervals.
Bern University Hospital Bern Switzerland
CHU Bordeaux and INSERM U1053 Bordeaux University Bordeaux France
Department of Gastroenterology and Hepatology Odense University Hospital Odense Denmark
Department of Gastroenterology Hepatology Antwerp University Hospital Antwerp Belgium
Department of Internal Medicine 1 Frankfurt University Hospital Frankfurt am Main Hessen Germany
Department of Radiology Beaujon University Hospital Clichy France
Department of Radiology Saint Jean Hospital Perpignan France
European Foundation for the Study of Chronic Liver Failure Barcelona Catalunya Spain
Fédération des Spécialités Digestives Hôpital Edouard Herriot Lyon France
Internal Medicine 1 University of Bonn Bonn Germany
Paris Cochin University Hopital Paris France
University Hospital and HIFIH Lab Angers France
University hospital Dubrava University of Zagreb School of Medicine Zagreb Zagreb Croatia
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22011147
- 003
- CZ-PrNML
- 005
- 20220506130520.0
- 007
- ta
- 008
- 220425s2022 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1136/gutjnl-2020-323419 $2 doi
- 035 __
- $a (PubMed)33479052
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Trebicka, Jonel $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany Jonel.Trebicka@kgu.de $u European Foundation for the Study of Chronic Liver Failure, Barcelona, Catalunya, Spain $1 https://orcid.org/0000000270283881
- 245 10
- $a Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease / $c J. Trebicka, W. Gu, V. de Ledinghen, C. Aubé, A. Krag, M. Praktiknjo, L. Castera, J. Dumortier, DJM. Bauer, M. Friedrich-Rust, S. Pol, I. Grgurevic, R. Zheng, S. Francque, H. Gottfriedovà, S. Mustapic, I. Sporea, A. Berzigotti, FE. Uschner, B. Simbrunner, M. Ronot, C. Cassinotto, M. Kjaergaard, F. Andrade, M. Schulz, G. Semmler, IT. Drinkovic, J. Chang, MJ. Brol, PE. Rautou, T. Vanwolleghem, CP. Strassburg, J. Boursier, PG. Ferstl, DN. Rasmussen, T. Reiberger, V. Vilgrain, A. Guibal, O. Guillaud, S. Zeuzem, C. Vassord, X. Lu, L. Vonghia, R. Senkerikova, A. Popescu, C. Margini, W. Wang, M. Thiele, C. Jansen
- 520 9_
- $a OBJECTIVE: Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients. DESIGN: This international multicentre cohort study included a derivation ACLD patient cohort with valid two-dimensional shear wave elastography (2D-SWE) results. Clinical and laboratory parameters at baseline and during follow-up were recorded. LSM by transient elastography (TE) was also recorded if available. The primary outcome was overall mortality. The secondary outcome was the development of first/further decompensation. RESULTS: After screening 2148 patients (16 centres), 1827 patients (55 years, 62.4% men) were included in the 2D-SWE cohort, with median liver SWE (L-SWE) 11.8 kPa and a model for end stage liver disease (MELD) score of 8. Combination of MELD score and L-SWE predict independently of mortality (AUC 0.8). L-SWE cut-off at ≥20 kPa combined with MELD ≥10 could stratify the risk of mortality and first/further decompensation in ACLD patients. The 2-year mortality and decompensation rates were 36.9% and 61.8%, respectively, in the 305 (18.3%) high-risk patients (with L-SWE ≥20 kPa and MELD ≥10), while in the 944 (56.6%) low-risk patients, these were 1.1% and 3.5%, respectively. Importantly, this M10LS20 algorithm was validated by TE-based LSM and in an additional cohort of 119 patients with valid point shear SWE-LSM. CONCLUSION: The M10LS20 algorithm allows risk stratification of patients with ACLD. Patients with L-SWE ≥20 kPa and MELD ≥10 should be followed closely and receive intensified care, while patients with low risk may be managed at longer intervals.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a algoritmy $7 D000465
- 650 _2
- $a chronická nemoc $7 D002908
- 650 12
- $a elastografie $7 D054459
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a nemoci jater $x diagnóza $x etiologie $x mortalita $7 D008107
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a ROC křivka $7 D012372
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a míra přežití $7 D015996
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a pozorovací studie $7 D064888
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Gu, Wenyi $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany $1 https://orcid.org/0000000216156064
- 700 1_
- $a de Ledinghen, Victor $u CHU Bordeaux and INSERM U1053, Bordeaux University, Bordeaux, France
- 700 1_
- $a Aubé, Christophe $u University Hospital and HIFIH Lab (UE3859), Angers, France
- 700 1_
- $a Krag, Aleksander $u Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark
- 700 1_
- $a Praktiknjo, Michael $u Internal Medicine I, University of Bonn, Bonn, Germany $1 https://orcid.org/0000000170339956
- 700 1_
- $a Castera, Laurent $u Department of Radiology, Beaujon University Hospital, Clichy, France
- 700 1_
- $a Dumortier, Jerome $u Fédération des Spécialités Digestives, Hôpital Edouard Herriot, Lyon, France
- 700 1_
- $a Bauer, David Josef Maria $u Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria
- 700 1_
- $a Friedrich-Rust, Mireen $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany
- 700 1_
- $a Pol, Stanislas $u Paris Cochin University Hopital, Paris, France
- 700 1_
- $a Grgurevic, Ivica $u University hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Zagreb, Croatia
- 700 1_
- $a Zheng, Rongqin $u Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
- 700 1_
- $a Francque, Sven $u InflaMed Centre of Excellence, Translational Sciences in Inflammation and Immunology, Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University Hospital Antwerp, Edegem, Antwerp, Belgium $u Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium $1 https://orcid.org/0000000275274714
- 700 1_
- $a Gottfriedovà, Halima $u Department of Hepato-Gastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 700 1_
- $a Mustapic, Sanda $u University hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Zagreb, Croatia
- 700 1_
- $a Sporea, Ioan $u Gastroenterology and Hepatology, University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania
- 700 1_
- $a Berzigotti, Annalisa $u Bern University Hospital, Bern, Switzerland
- 700 1_
- $a Uschner, Frank Erhard $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany $1 https://orcid.org/0000000237602887
- 700 1_
- $a Simbrunner, Benedikt $u Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria
- 700 1_
- $a Ronot, Maxime $u Department of Radiology, Beaujon University Hospital, Clichy, France
- 700 1_
- $a Cassinotto, Christophe $u University Hospital and HIFIH Lab (UE3859), Angers, France $1 https://orcid.org/0000000151364742
- 700 1_
- $a Kjaergaard, Maria $u Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark
- 700 1_
- $a Andrade, Filipe $u Department of Radiology, Beaujon University Hospital, Clichy, France
- 700 1_
- $a Schulz, Martin $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany
- 700 1_
- $a Semmler, Georg $u Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria
- 700 1_
- $a Drinkovic, Ida Tjesic $u University hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Zagreb, Croatia
- 700 1_
- $a Chang, Johannes $u Internal Medicine I, University of Bonn, Bonn, Germany
- 700 1_
- $a Brol, Maximilian Joseph $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany
- 700 1_
- $a Rautou, Pierre Emmanuel $u Department of Radiology, Beaujon University Hospital, Clichy, France
- 700 1_
- $a Vanwolleghem, Thomas $u InflaMed Centre of Excellence, Translational Sciences in Inflammation and Immunology, Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University Hospital Antwerp, Edegem, Antwerp, Belgium $u Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium
- 700 1_
- $a Strassburg, Christian P $u Internal Medicine I, University of Bonn, Bonn, Germany
- 700 1_
- $a Boursier, Jerome $u University Hospital and HIFIH Lab (UE3859), Angers, France $1 https://orcid.org/0000000272821436
- 700 1_
- $a Ferstl, Philip Georg $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany
- 700 1_
- $a Rasmussen, Ditlev Nytoft $u Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark
- 700 1_
- $a Reiberger, Thomas $u Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Wien, Austria $1 https://orcid.org/0000000245903583
- 700 1_
- $a Vilgrain, Valerie $u Department of Radiology, Beaujon University Hospital, Clichy, France
- 700 1_
- $a Guibal, Aymeric $u Department of Radiology, Saint Jean Hospital, Perpignan, France
- 700 1_
- $a Guillaud, Olivier $u Fédération des Spécialités Digestives, Hôpital Edouard Herriot, Lyon, France
- 700 1_
- $a Zeuzem, Stefan $u Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt am Main, Hessen, Germany
- 700 1_
- $a Vassord, Camille $u Paris Cochin University Hopital, Paris, France
- 700 1_
- $a Lu, Xue $u Department of Ultrasound, Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
- 700 1_
- $a Vonghia, Luisa $u InflaMed Centre of Excellence, Translational Sciences in Inflammation and Immunology, Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University Hospital Antwerp, Edegem, Antwerp, Belgium $u Department of Gastroenterology Hepatology, Antwerp University Hospital, Antwerp, Belgium
- 700 1_
- $a Senkerikova, Renata $u Department of Hepato-Gastroenterology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
- 700 1_
- $a Popescu, Alina $u Gastroenterology and Hepatology, University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania
- 700 1_
- $a Margini, Cristina $u Bern University Hospital, Bern, Switzerland
- 700 1_
- $a Wang, Wenping $u Zhongshan Hospital Fudan University, Shanghai, Shanghai, China
- 700 1_
- $a Thiele, Maja $u Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark $1 https://orcid.org/0000000318541924
- 700 1_
- $a Jansen, Chrisitan $u Internal Medicine I, University of Bonn, Bonn, Germany
- 773 0_
- $w MED00009778 $t Gut $x 1468-3288 $g Roč. 71, č. 2 (2022), s. 402-414
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/33479052 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20220425 $b ABA008
- 991 __
- $a 20220506130512 $b ABA008
- 999 __
- $a ok $b bmc $g 1788969 $s 1162345
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 71 $c 2 $d 402-414 $e 20210121 $i 1468-3288 $m Gut $n Gut $x MED00009778
- LZP __
- $a Pubmed-20220425
