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Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death
DE. Votkina, EV. Plotnikov, PV. Petunin, ES. Berdinskaya, MS. Tretyakova, G. Audran, SRA. Marque, PS. Postnikov
Molecular pharmaceutics.
2022 ;
19 (1) :
354-357.
[pub] 20211210
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc22011406
- MeSH
- buněčná smrt účinky léků MeSH
- fotochemoterapie metody MeSH
- fotosenzibilizující látky farmakologie MeSH
- lidé MeSH
- MFC-7 buňky účinky léků MeSH
- volné radikály metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Two alkylated verdazyl radicals (AlkVZs) were investigated as active compounds for photoinitiated controlled MCF-7 cell death. Observed results unambiguously showed that AlkVZ could be a potential structural moiety for the design of a novel family of photodynamic therapy agents. The main advantage of the proposed substances is an oxygen-independent generation of active radicals, which play a pivotal role in the treatment of oxygen-deficient tumors.
Citace poskytuje Crossref.org
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