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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
GAM. Blokland, J. Grove, CY. Chen, C. Cotsapas, S. Tobet, R. Handa, Schizophrenia Working Group of the Psychiatric Genomics Consortium, D. St Clair, T. Lencz, BJ. Mowry, S. Periyasamy, MJ. Cairns, PA. Tooney, JQ. Wu, B. Kelly, G. Kirov, PF....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural
Grantová podpora
G0901310
Medical Research Council - United Kingdom
R01 MH092380
NIMH NIH HHS - United States
U54 MH118919
NIMH NIH HHS - United States
- MeSH
- bipolární porucha genetika MeSH
- celogenomová asociační studie MeSH
- depresivní porucha unipolární * genetika MeSH
- endoteliální buňky MeSH
- genetická predispozice k nemoci MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- pohlavní dimorfismus * MeSH
- psychotické poruchy * genetika MeSH
- receptory vaskulárního endoteliálního růstového faktoru MeSH
- schizofrenie genetika MeSH
- sulfurtransferasy MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. METHODS: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. RESULTS: Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10-8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10-6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10-7; rs73033497, p = 8.8 × 10-7; rs7914279, p = 6.4 × 10-7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10-7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10-7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10-7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). CONCLUSIONS: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.
Amsterdam Public Health Research Institute Amsterdam UMC Amsterdam the Netherlands
Biogen Inc Cambridge Massachusetts
Bioinformatics Research Centre Aarhus Denmark
Broad Institute of MIT and Harvard Cambridge Massachusetts
Center for Genome Analysis and Personalized Medicine Aarhus Denmark
Center for Psychopharmacology Diakonhjemmet Hospital Oslo Norway
Centre for Addiction and Mental Health Toronto Ontario Canada
Centre for Genomic Sciences The University of Hong Kong Hong Kong SAR China
Centre for Human Genetics University of Marburg Marburg Germany
Centre for Integrated Register based Research Aarhus University Aarhus Denmark
Centre for Integrative Sequencing Aarhus University Aarhus Denmark
Child and Adolescent Psychiatry Erasmus Medical Center Rotterdam the Netherlands
Concert Pharmaceuticals Inc Lexington Massachusetts
Department of Biomedical Sciences Colorado State University Fort Collins Colorado
Department of Biomedicine Aarhus University Aarhus Denmark
Department of Biomedicine University of Basel Basel Switzerland
Department of Clinical Neuroscience Max Planck Institute of Experimental Medicine Göttingen Germany
Department of Clinical Neuroscience Psychiatry Section Karolinska Institutet Stockholm Sweden
Department of Clinical Sciences Psychiatry Umeå University Medical Faculty Umeå Sweden
Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Lodz Poland
Department of Health Sciences Research Mayo Clinic Rochester Minnesota
Department of Human Genetics University of California Los Angeles California
Department of Medical and Molecular Genetics King's College London London United Kingdom
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Medical Genetics Oslo University Hospital Oslo Norway
Department of Mental Health Norwegian University of Science and Technology NTNU Trondheim Norway
Department of Pharmaceutical Biosciences School of Pharmacy University of Oslo Oslo Norway
Department of Psychiatry and Addiction Medicine Assistance Publique Hôpitaux de Paris Paris France
Department of Psychiatry and Behavioral Neuroscience University of Chicago Chicago Illinois
Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University Syracuse New York
Department of Psychiatry and Psychology Mayo Clinic Rochester Minnesota
Department of Psychiatry and Psychotherapy University Medical Center Göttingen Göttingen Germany
Department of Psychiatry and Psychotherapy University Medicine Greifswald Greifswald Germany
Department of Psychiatry Columbia University College of Physicians and Surgeons New York New York
Department of Psychiatry Dalhousie University Halifax Nova Scotia Canada
Department of Psychiatry Fujita Health University School of Medicine Toyoake Aichi Japan
Department of Psychiatry Harvard Medical School Boston Massachusetts
Department of Psychiatry Icahn School of Medicine at Mount Sinai New York New York
Department of Psychiatry St Olavs' University Hospital Trondheim Norway
Department of Psychiatry University of California San Diego La Jolla California
Department of Psychiatry University of Halle Halle Germany
Department of Psychiatry University of Iowa Iowa City Iowa
Department of Psychiatry University of Munich Munich Germany
Department of Psychiatry University of Münster Münster Germany
Department of Psychiatry Vrije Universiteit Medical Center and GGZ inGeest Amsterdam the Netherlands
Department of Translational Research in Psychiatry Max Planck Institute of Psychiatry Munich Germany
Departments of Neurology and Genetics Yale School of Medicine New Haven Connecticut
Departments of Psychiatry and Medicine Harvard Medical School Boston Massachusetts
Discipline of Psychiatry The University of Adelaide Adelaide South Austrlalia Australia
Division of Cancer Epidemiology and Genetics National Cancer Institute Bethesda Maryland
Division of Psychiatry University of Edinburgh Edinburgh United Kingdom
Division of Translational Epidemiology New York State Psychiatric Institute New York New York
Duke National University of Singapore Graduate Medical School Singapore
Faculté de Médecine Université Paris Est Créteil France
Friedman Brain Institute Icahn School of Medicine at Mount Sinai New York New York
Innovation Center on Sex Differences in Medicine Massachusetts General Hospital Boston Massachusetts
INSERM U955 Psychiatrie Translationnelle Créteil France
Institut national de la santé et de la recherche médicale Paris France
Institute for Genomic Health SUNY Downstate Medical Center College of Medicine Brooklyn New York
Institute for Molecular Medicine Finland University of Helsinki Helsinki Finland
Institute of Community Medicine University Medicine Greifswald Greifswald Germany
Institute of Genomics University of Tartu Tartu Estonia
Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland
Institute of Neuroscience and Medicine Research Centre Jülich Jülich Germany
Institute of Psychiatric Phenomics and Genomics University Hospital LMU Munich Munich Germany
Institute of Psychiatry King's College London London United Kingdom
International Max Planck Research School for Translational Psychiatry Munich Germany
Kaiser Permanente Northern California San Francisco California
Lieber Institute for Brain Development Baltimore Maryland
Max Planck Institute of Psychiatry Munich Germany
Medical and Population Genetics Broad Institute of MIT and Harvard Cambridge Massachusetts
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging Charlestown Massachusetts
Munich Cluster for Systems Neurology Munich Germany
National Centre for Register Based Research Aarhus University Aarhus Denmark
National Institute of Mental Health Klecany Czech Republic
Neuroscience Research Australia Sydney New South Wales Australia
NIHR Maudsley Biomedical Research Centre King's College London London United Kingdom
NORMENT Centre Department of Clinical Science University of Bergen Bergen Norway
Paris Bipolar and TRD Expert Centres FondaMental Foundation Paris France
Psychiatry and Behavioral Sciences Stanford University Stanford California
Psychiatry and The Behavioral Sciences University of Southern California Los Angeles California
Psychiatry Université Paris Diderot Paris France
Psychosis Research Unit Aarhus University Hospital Risskov Denmark
Queensland Brain Institute University of Queensland Brisbane Queensland Australia
Queensland Centre for Mental Health Research University of Queensland Brisbane Queensland Australia
Research Institute Lindner Center of HOPE Mason Ohio
Schizophrenia Research Institute Sydney New South Wales Australia
School of Medical Sciences University of New South Wales Sydney New South Wales Australia
School of Psychiatry University of New South Wales Sydney New South Wales Australia
School of Psychology University of Queensland Brisbane Queensland Australia
Social Genetic and Developmental Psychiatry Centre King's College London London United Kingdom
Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard Cambridge Massachusetts
The Feinstein Institute for Medical Research Manhasset New York
The Lundbeck Foundation Initiative for Integrative Psychiatric Research Copenhagen Denmark
The Zucker Hillside Hospital Glen Oaks New York
The Zucker School of Medicine at Hofstra Northwell Hempstead New York
University of Aberdeen Institute of Medical Sciences Aberdeen United Kingdom
Citace poskytuje Crossref.org
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- $a Blokland, Gabriëlla A M $u Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands; Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Electronic address: gam.blokland@maastrichtuniversity.nl
- 245 10
- $a Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders / $c GAM. Blokland, J. Grove, CY. Chen, C. Cotsapas, S. Tobet, R. Handa, Schizophrenia Working Group of the Psychiatric Genomics Consortium, D. St Clair, T. Lencz, BJ. Mowry, S. Periyasamy, MJ. Cairns, PA. Tooney, JQ. Wu, B. Kelly, G. Kirov, PF. Sullivan, A. Corvin, BP. Riley, T. Esko, L. Milani, EG. Jönsson, A. Palotie, H. Ehrenreich, M. Begemann, A. Steixner-Kumar, PC. Sham, N. Iwata, DR. Weinberger, PV. Gejman, AR. Sanders, JD. Buxbaum, D. Rujescu, I. Giegling, B. Konte, AM. Hartmann, E. Bramon, RM. Murray, MT. Pato, J. Lee, I. Melle, E. Molden, RA. Ophoff, A. McQuillin, NJ. Bass, R. Adolfsson, AK. Malhotra, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, NG. Martin, JM. Fullerton, PB. Mitchell, PR. Schofield, AJ. Forstner, F. Degenhardt, S. Schaupp, AL. Comes, M. Kogevinas, J. Guzman-Parra, A. Reif, F. Streit, L. Sirignano, S. Cichon, M. Grigoroiu-Serbanescu, J. Hauser, J. Lissowska, F. Mayoral, B. Müller-Myhsok, B. Świątkowska, TG. Schulze, MM. Nöthen, M. Rietschel, J. Kelsoe, M. Leboyer, S. Jamain, B. Etain, F. Bellivier, JB. Vincent, M. Alda, C. O'Donovan, P. Cervantes, JM. Biernacka, M. Frye, SL. McElroy, LJ. Scott, EA. Stahl, M. Landén, ML. Hamshere, OB. Smeland, S. Djurovic, AE. Vaaler, OA. Andreassen, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, BT. Baune, T. Air, M. Preisig, R. Uher, DF. Levinson, MM. Weissman, JB. Potash, J. Shi, JA. Knowles, RH. Perlis, S. Lucae, DI. Boomsma, BWJH. Penninx, JJ. Hottenga, EJC. de Geus, G. Willemsen, Y. Milaneschi, H. Tiemeier, HJ. Grabe, A. Teumer, S. Van der Auwera, U. Völker, SP. Hamilton, PKE. Magnusson, A. Viktorin, D. Mehta, N. Mullins, MJ. Adams, G. Breen, AM. McIntosh, CM. Lewis, Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium, iPSYCH, DM. Hougaard, M. Nordentoft, O. Mors, PB. Mortensen, T. Werge, TD. Als, AD. Børglum, TL. Petryshen, JW. Smoller, JM. Goldstein
- 520 9_
- $a BACKGROUND: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. METHODS: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. RESULTS: Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10-8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10-6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10-7; rs73033497, p = 8.8 × 10-7; rs7914279, p = 6.4 × 10-7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10-7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10-7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10-7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). CONCLUSIONS: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.
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- 700 1_
- $a Grove, Jakob $u Department of Biomedicine, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Center for Genome Analysis and Personalized Medicine, Aarhus, Denmark; Bioinformatics Research Centre (BiRC), Aarhus, Denmark
- 700 1_
- $a Chen, Chia-Yen $u Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Biogen Inc., Cambridge, Massachusetts
- 700 1_
- $a Cotsapas, Chris $u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Departments of Neurology and Genetics, Yale School of Medicine, New Haven, Connecticut
- 700 1_
- $a Tobet, Stuart $u Innovation Center on Sex Differences in Medicine (ICON), Massachusetts General Hospital, Boston, Massachusetts; Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado
- 700 1_
- $a Handa, Robert $u Innovation Center on Sex Differences in Medicine (ICON), Massachusetts General Hospital, Boston, Massachusetts; Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado
- 700 1_
- $a St Clair, David $u University of Aberdeen, Institute of Medical Sciences, Aberdeen, United Kingdom
- 700 1_
- $a Lencz, Todd $u The Feinstein Institute for Medical Research, Manhasset, New York; The Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York; The Zucker Hillside Hospital, Glen Oaks, New York
- 700 1_
- $a Mowry, Bryan J $u Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland, Australia
- 700 1_
- $a Periyasamy, Sathish $u Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Queensland Centre for Mental Health Research, The Park - Centre for Mental Health, Wacol, Queensland, Australia
- 700 1_
- $a Cairns, Murray J $u Schizophrenia Research Institute, Sydney, New South Wales, Australia; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia; Priority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia
- 700 1_
- $a Tooney, Paul A $u School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia; Priority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia; Schizophrenia Research Institute, Sydney, New South Wales, Australia
- 700 1_
- $a Wu, Jing Qin $u School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia; Schizophrenia Research Institute, Sydney, New South Wales, Australia
- 700 1_
- $a Kelly, Brian $u Priority Centre for Translational Neuroscience and Mental Health, University of Newcastle, Newcastle, New South Wales, Australia
- 700 1_
- $a Kirov, George $u MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom
- 700 1_
- $a Sullivan, Patrick F $u Departments of Genetics and Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Corvin, Aiden $u Neuropsychiatric Genetics Research Group, Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
- 700 1_
- $a Riley, Brien P $u Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Psychiatry and Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia
- 700 1_
- $a Esko, Tõnu $u Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Institute of Genomics, University of Tartu, Tartu, Estonia
- 700 1_
- $a Milani, Lili $u Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Institute of Genomics, University of Tartu, Tartu, Estonia
- 700 1_
- $a Jönsson, Erik G $u Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institutet, Stockholm, Sweden; Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway
- 700 1_
- $a Palotie, Aarno $u Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
- 700 1_
- $a Ehrenreich, Hannelore $u Department of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany
- 700 1_
- $a Begemann, Martin $u Department of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany
- 700 1_
- $a Steixner-Kumar, Agnes $u Department of Clinical Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany
- 700 1_
- $a Sham, Pak C $u Department of Psychiatry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR China; State Key Laboratory for Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR China; Centre for Genomic Sciences, The University of Hong Kong, Hong Kong, SAR China
- 700 1_
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- 700 1_
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- 700 1_
- $a Gejman, Pablo V $u Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, Illinois; Department of Psychiatry and Behavioral Sciences, North Shore University Health System, Evanston, Illinois
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Bramon, Elvira $u Mental Health Neuroscience Research Department, Division of Psychiatry, Faculty of Brain Sciences, University College London, London, United Kingdom
- 700 1_
- $a Murray, Robin M $u Institute of Psychiatry, King's College London, London, United Kingdom
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Müller-Myhsok, Bertram $u University of Liverpool, Liverpool, United Kingdom; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
- 700 1_
- $a Świątkowska, Beata $u Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
- 700 1_
- $a Schulze, Thomas G $u Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, New York; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany
- 700 1_
- $a Nöthen, Markus M $u Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
- 700 1_
- $a Rietschel, Marcella $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
- 700 1_
- $a Kelsoe, John $u Department of Psychiatry, University of California San Diego, La Jolla, California
- 700 1_
- $a Leboyer, Marion $u Faculté de Médecine, Université Paris Est, Créteil, France; Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France; Institut national de la santé et de la recherche médicale (INSERM), Paris, France
- 700 1_
- $a Jamain, Stéphane $u Faculté de Médecine, Université Paris Est, Créteil, France; INSERM U955, Psychiatrie Translationnelle, Créteil, France
- 700 1_
- $a Etain, Bruno $u Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom; Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France; UMR-S1144 Team 1 Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, France; Psychiatry, Université Paris Diderot, Paris, France
- 700 1_
- $a Bellivier, Frank $u Department of Psychiatry and Addiction Medicine, Assistance Publique - Hôpitaux de Paris, Paris, France; UMR-S1144 Team 1 Biomarkers of relapse and therapeutic response in addiction and mood disorders, INSERM, Paris, France; Psychiatry, Université Paris Diderot, Paris, France; Paris Bipolar and TRD Expert Centres, FondaMental Foundation, Paris, France
- 700 1_
- $a Vincent, John B $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada
- 700 1_
- $a Alda, Martin $u Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada; National Institute of Mental Health, Klecany, Czech Republic
- 700 1_
- $a O'Donovan, Claire $u Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
- 700 1_
- $a Cervantes, Pablo $u Department of Psychiatry, Mood Disorders Program, McGill University Health Center, Montréal, Québec, Canada
- 700 1_
- $a Biernacka, Joanna M $u Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota
- 700 1_
- $a Frye, Mark $u Department of Psychiatry & Psychology, Mayo Clinic, Rochester, Minnesota
- 700 1_
- $a McElroy, Susan L $u Research Institute, Lindner Center of HOPE, Mason, Ohio
- 700 1_
- $a Scott, Laura J $u Center for Statistical Genetics and Department of Biostatistics, University of Michigan, Ann Arbor, Michigan
- 700 1_
- $a Stahl, Eli A $u Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York
- 700 1_
- $a Landén, Mikael $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Institute of Neuroscience and Physiology, the Sahlgrenska Academy at Gothenburg University, Gothenburg, Sweden
- 700 1_
- $a Hamshere, Marian L $u MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom
- 700 1_
- $a Smeland, Olav B $u Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- 700 1_
- $a Djurovic, Srdjan $u Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; NORMENT Centre, Department of Clinical Science, University of Bergen, Bergen, Norway
- 700 1_
- $a Vaaler, Arne E $u Department of Mental Health, Norwegian University of Science and Technology - NTNU, Trondheim, Norway; Department of Psychiatry, St Olavs' University Hospital, Trondheim, Norway
- 700 1_
- $a Andreassen, Ole A $u Norwegian Centre for Mental Disorders Research (NORMENT), Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway
- 700 1_
- $a Baune, Bernhard T $u Department of Psychiatry, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia; Florey Institute for Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia; Department of Psychiatry, University of Münster, Münster, Germany
- 700 1_
- $a Air, Tracy $u Discipline of Psychiatry, The University of Adelaide, Adelaide, South Austrlalia, Australia
- 700 1_
- $a Preisig, Martin $u Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland
- 700 1_
- $a Uher, Rudolf $u Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
- 700 1_
- $a Levinson, Douglas F $u Psychiatry & Behavioral Sciences, Stanford University, Stanford, California
- 700 1_
- $a Weissman, Myrna M $u Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York; Division of Translational Epidemiology, New York State Psychiatric Institute, New York, New York
- 700 1_
- $a Potash, James B $u Department of Psychiatry, University of Iowa, Iowa City, Iowa
- 700 1_
- $a Shi, Jianxin $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
- 700 1_
- $a Knowles, James A $u Psychiatry & The Behavioral Sciences, University of Southern California, Los Angeles, California
- 700 1_
- $a Perlis, Roy H $u Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts
- 700 1_
- $a Lucae, Susanne $u Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany; Max Planck Institute of Psychiatry, Munich, Germany
- 700 1_
- $a Boomsma, Dorret I $u Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands
- 700 1_
- $a Penninx, Brenda W J H $u Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, the Netherlands
- 700 1_
- $a Hottenga, Jouke-Jan $u Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands
- 700 1_
- $a de Geus, Eco J C $u Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands
- 700 1_
- $a Willemsen, Gonneke $u Department of Biological Psychology/Netherlands Twin Register, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands
- 700 1_
- $a Milaneschi, Yuri $u Department of Psychiatry, Vrije Universiteit Medical Center and GGZ inGeest, Amsterdam, the Netherlands
- 700 1_
- $a Tiemeier, Henning $u Child and Adolescent Psychiatry, Erasmus Medical Center, Rotterdam, the Netherlands
- 700 1_
- $a Grabe, Hans J $u Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
- 700 1_
- $a Teumer, Alexander $u Institute of Community Medicine, University Medicine Greifswald, Greifswald, Germany
- 700 1_
- $a Van der Auwera, Sandra $u Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany
- 700 1_
- $a Völker, Uwe $u Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
- 700 1_
- $a Hamilton, Steven P $u Kaiser Permanente Northern California, San Francisco, California
- 700 1_
- $a Magnusson, Patrik K E $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Viktorin, Alexander $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Mehta, Divya $u School of Psychology and Counseling, Queensland University of Technology, Brisbane, Queensland, Australia
- 700 1_
- $a Mullins, Niamh $u Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Social, Genetic and Developmental Psychiatry Centre, King's College London, London, United Kingdom
- 700 1_
- $a Adams, Mark J $u Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom
- 700 1_
- $a Breen, Gerome $u NIHR Maudsley Biomedical Research Centre, King's College London, London, United Kingdom
- 700 1_
- $a McIntosh, Andrew M $u Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom
- 700 1_
- $a Lewis, Cathryn M $u Department of Medical & Molecular Genetics, King's College London, London, United Kingdom
- 700 1_
- $a Hougaard, David M $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Center for Neonatal Screening, Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
- 700 1_
- $a Nordentoft, Merete $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Copenhagen Mental Health Center, Mental Health Services Capital Region of Denmark Copenhagen, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 700 1_
- $a Mors, Ole $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Psychosis Research Unit, Aarhus University Hospital, Risskov, Denmark
- 700 1_
- $a Mortensen, Preben B $u Centre for Integrative Sequencing (iSEQ), Aarhus University, Aarhus, Denmark; National Centre for Register-Based Research (NCCR), Aarhus University, Aarhus, Denmark; Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark
- 700 1_
- $a Werge, Thomas $u Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Copenhagen, Roskilde, Denmark
- 700 1_
- $a Als, Thomas D $u Department of Biomedicine, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Center for Genome Analysis and Personalized Medicine, Aarhus, Denmark
- 700 1_
- $a Børglum, Anders D $u Department of Biomedicine, Aarhus University, Aarhus, Denmark; The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Copenhagen, Denmark; Center for Genome Analysis and Personalized Medicine, Aarhus, Denmark
- 700 1_
- $a Petryshen, Tracey L $u Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Concert Pharmaceuticals, Inc., Lexington, Massachusetts
- 700 1_
- $a Smoller, Jordan W $u Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Massachusetts
- 700 1_
- $a Goldstein, Jill M $u Innovation Center on Sex Differences in Medicine (ICON), Massachusetts General Hospital, Boston, Massachusetts; Department of Psychiatry and Vincent Department of Obstetrics, Gynecology & Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts; MGH-MIT-HMS Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts; Departments of Psychiatry and Medicine, Harvard Medical School, Boston, Massachusetts. Electronic address: jill_goldstein@hms.harvard.edu
- 710 2_
- $a Schizophrenia Working Group of the Psychiatric Genomics Consortium
- 710 2_
- $a Bipolar Disorder Working Group of the Psychiatric Genomics Consortium
- 710 2_
- $a Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
- 710 2_
- $a Sex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium
- 710 2_
- $a iPSYCH
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