• Something wrong with this record ?

Structural correlates of trauma-induced hyperarousal in mice

J. Ruat, DE. Heinz, FP. Binder, T. Stark, R. Neuner, A. Hartmann, PM. Kaplick, A. Chen, M. Czisch, CT. Wotjak

. 2021 ; 111 (-) : 110404. [pub] 20210722

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22011675

Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22011675
003      
CZ-PrNML
005      
20220506130158.0
007      
ta
008      
220425s2021 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.pnpbp.2021.110404 $2 doi
035    __
$a (PubMed)34303744
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Ruat, Julia $u Department Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804 Munich, Germany
245    10
$a Structural correlates of trauma-induced hyperarousal in mice / $c J. Ruat, DE. Heinz, FP. Binder, T. Stark, R. Neuner, A. Hartmann, PM. Kaplick, A. Chen, M. Czisch, CT. Wotjak
520    9_
$a Post-traumatic stress disorder (PTSD) is a chronic disease caused by traumatic incidents. Numerous studies have revealed grey matter volume differences in affected individuals. The nature of the disease renders it difficult to distinguish between a priori versus a posteriori changes. To overcome this difficulty, we studied the consequences of a traumatic event on brain morphology in mice before and 4 weeks after exposure to brief foot shocks (or sham treatment), and correlated morphology with symptoms of hyperarousal. In the latter context, we assessed hyperarousal upon confrontation with acoustic, visual, or composite (acoustic/visual/tactile) threats and integrated the individual readouts into a single Hyperarousal Score using logistic regression analysis. MRI scans with subsequent whole-brain deformation-based morphometry (DBM) analysis revealed a volume decrease of the dorsal hippocampus and an increase of the reticular nucleus in shocked mice when compared to non-shocked controls. Using the Hyperarousal Score as regressor for the post-exposure MRI measurement, we observed negative correlations with several brain structures including the dorsal hippocampus. If the development of changes with respect to the basal MRI was considered, reduction in globus pallidus volume reflected hyperarousal severity. Our findings demonstrate that a brief traumatic incident can cause volume changes in defined brain structures and suggest the globus pallidus as an important hub for the control of fear responses to threatening stimuli of different sensory modalities.
650    _2
$a zvířata $7 D000818
650    _2
$a arousal $x fyziologie $7 D001143
650    _2
$a mozek $x patofyziologie $7 D001921
650    _2
$a globus pallidus $7 D005917
650    _2
$a šedá hmota $x fyziologie $7 D066128
650    _2
$a hipokampus $7 D006624
650    _2
$a počítačové zpracování obrazu $7 D007091
650    _2
$a magnetická rezonanční tomografie $7 D008279
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myši $7 D051379
650    _2
$a posttraumatická stresová porucha $x patofyziologie $7 D013313
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Heinz, Daniel E $u Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Max Planck School of Cognition, 04103 Leipzig, Germany
700    1_
$a Binder, Florian P $u International Max Planck Research School for Translational Psychiatry (IMPRS-TP), 80804 Munich, Germany; Department Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804 Munich, Germany
700    1_
$a Stark, Tibor $u Scientific Core Unit Neuroimaging, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Pharmacology, Faculty of Medicine, Masaryk University, 62500 Brno, Czechia
700    1_
$a Neuner, Robert $u Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804 Munich, Germany
700    1_
$a Hartmann, Alice $u Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804 Munich, Germany
700    1_
$a Kaplick, Paul M $u Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804 Munich, Germany
700    1_
$a Chen, Alon $u Department Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel
700    1_
$a Czisch, Michael $u Scientific Core Unit Neuroimaging, Max Planck Institute of Psychiatry, 80804 Munich, Germany
700    1_
$a Wotjak, Carsten T $u Research Group Neuronal Plasticity, Max Planck Institute of Psychiatry, 80804 Munich, Germany; Max Planck School of Cognition, 04103 Leipzig, Germany; Central Nervous System Diseases Research (CNSDR), Boehringer Ingelheim Pharma GmbH & Co KG, 88397, Biberach an der Riss, Germany. Electronic address: wotjak@psych.mpg.de
773    0_
$w MED00003930 $t Progress in neuro-psychopharmacology & biological psychiatry $x 1878-4216 $g Roč. 111, č. - (2021), s. 110404
856    41
$u https://pubmed.ncbi.nlm.nih.gov/34303744 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20220506130150 $b ABA008
999    __
$a ok $b bmc $g 1789330 $s 1162873
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 111 $c - $d 110404 $e 20210722 $i 1878-4216 $m Progress in neuro-psychopharmacology & biological psychiatry $n Prog Neuropsychopharmacol Biol Psychiatry $x MED00003930
LZP    __
$a Pubmed-20220425

Find record

Citation metrics

Archiving options