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Toxicity of silver nanoparticles on endometrial receptivity in female mice
M. Ajdary, S. Eghbali, VP. Mahabadi, F. Keyhanfar, RS. Varma
Jazyk angličtina Země Kanada
Typ dokumentu časopisecké články
PubMed
34283933
DOI
10.1139/cjpp-2021-0094
Knihovny.cz E-zdroje
- MeSH
- endometrium účinky léků metabolismus MeSH
- implantace embrya účinky léků MeSH
- interleukin-1beta metabolismus MeSH
- interleukin-6 metabolismus MeSH
- kovové nanočástice toxicita MeSH
- myši MeSH
- stříbro toxicita MeSH
- těhotenství MeSH
- velikost částic MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Nanoparticles (NPs) have many toxic effects on fertility and can prevent successful implantation by affecting the maternal uterine tissue. Herein, by deploying 30 female NMRI mice, the effect of silver NPs on the endometrium and implantation has been investigated. Using spherical silver NPs of a diameter of 18-30 nm at doses of 2 and 4 mg/kg, mice in two groups were treated. Then, female mice mated with male mice. Endometrial tissue was extracted 4.5 days later. On the fourth day of pregnancy, the mice were anesthetized and blood samples were taken from the heart; furthermore, endometrial tissue was isolated and used for molecular tests, inductively coupled plasma, and examination of pinopods. The results revealed that the levels of interleukin 6 (IL-6) and IL-1β and the accumulation of NPs in endometrial tissue in the group receiving NPs at a dose of 4 mg/kg had a major increase relative to the other two groups (p < 0.05); the group receiving a dose of 4 mg/kg exhibited a decrease in pinopods and microvillus compared with the other two groups. According to the results, NPs can reach the endometrium, suggesting that caution should be exercised due to serious exposure to NPs throughout pregnancy.
Department of Anatomical Science Iran University of Medical Sciences Tehran Iran
Department of Pharmacology School of Medicine Iran University of Medical Sciences Tehran Iran
Endometriosis Research Center Iran University of Medical Sciences Tehran Iran
Student Research Committee Iran University of Medical Sciences Tehran Iran
Citace poskytuje Crossref.org
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