• Je něco špatně v tomto záznamu ?

Local and Systemic Expression Pattern of MMP-2 and MMP-9 in Complex Regional Pain Syndrome

F. Escolano-Lozano, E. Gries, T. Schlereth, V. Dimova, P. Baka, E. Vlckova, S. König, F. Birklein

. 2021 ; 22 (10) : 1294-1302. [pub] 20210420

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22012154

Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy subjects. All samples were analyzed with ELISA. Concentrations were then compared to clinical data as well as to quantitative sensory testing data.MMP-2 was increased in both ipsi- and contralateral skin biopsies of CRPS patients compared to healthy subjects. While low ipsilateral MMP-2 was associated with trophic changes, contralateral MMP-2 inversely correlated with the CRPS severity. MMP-9 was also locally increased in ipsilateral CRPS skin, and higher ipsi- and contralateral MMP-9 levels correlated with CRPS severity. We conclude that MMP-2 and MMP-9 are differently expressed depending on the clinical phenotype in CRPS. PERSPECTIVE: This article describes an upregulation of MMPs in CRPS and pain controls and shows different expression of MMP-2 and -9 depending on clinical phenotype in CRPS. These results provide evidence that MMP-2 and -9 play a key role in CRPS pathophysiology.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22012154
003      
CZ-PrNML
005      
20220506130807.0
007      
ta
008      
220425s2021 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.jpain.2021.04.002 $2 doi
035    __
$a (PubMed)33892152
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Escolano-Lozano, Fabiola $u University Hospital Mainz, Neurology Department, Mainz, Germany. Electronic address: fabiola.escolano@unimedizin-mainz.de
245    10
$a Local and Systemic Expression Pattern of MMP-2 and MMP-9 in Complex Regional Pain Syndrome / $c F. Escolano-Lozano, E. Gries, T. Schlereth, V. Dimova, P. Baka, E. Vlckova, S. König, F. Birklein
520    9_
$a Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy subjects. All samples were analyzed with ELISA. Concentrations were then compared to clinical data as well as to quantitative sensory testing data.MMP-2 was increased in both ipsi- and contralateral skin biopsies of CRPS patients compared to healthy subjects. While low ipsilateral MMP-2 was associated with trophic changes, contralateral MMP-2 inversely correlated with the CRPS severity. MMP-9 was also locally increased in ipsilateral CRPS skin, and higher ipsi- and contralateral MMP-9 levels correlated with CRPS severity. We conclude that MMP-2 and MMP-9 are differently expressed depending on the clinical phenotype in CRPS. PERSPECTIVE: This article describes an upregulation of MMPs in CRPS and pain controls and shows different expression of MMP-2 and -9 depending on clinical phenotype in CRPS. These results provide evidence that MMP-2 and -9 play a key role in CRPS pathophysiology.
650    _2
$a dospělí $7 D000328
650    _2
$a biopsie $7 D001706
650    _2
$a komplexní regionální syndromy bolesti $x metabolismus $x patofyziologie $7 D020918
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a zánět $x metabolismus $7 D007249
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a matrixová metaloproteinasa 2 $x metabolismus $7 D020778
650    _2
$a matrixová metaloproteinasa 9 $x metabolismus $7 D020780
650    _2
$a lidé středního věku $7 D008875
650    _2
$a stupeň závažnosti nemoci $7 D012720
650    _2
$a kůže $7 D012867
655    _2
$a časopisecké články $7 D016428
700    1_
$a Gries, Eva $u University Hospital Mainz, Cardiology Department, Mainz, Germany
700    1_
$a Schlereth, Tanja $u DKD Helios Klinik Wiesbaden, Department of Neurology, Wiesbaden, Germany
700    1_
$a Dimova, Violeta $u University Hospital Mainz, Neurology Department, Mainz, Germany
700    1_
$a Baka, Panoraia $u University Hospital Mainz, Neurology Department, Mainz, Germany
700    1_
$a Vlckova, Eva $u University Hospital Brno, Neurology Department, Brno, Czech Republic
700    1_
$a König, Simone $u Core Unit Proteomics, Interdisciplinary Center for Clinical Research, Medical Faculty, University of Münster, Germany
700    1_
$a Birklein, Frank $u University Hospital Mainz, Neurology Department, Mainz, Germany
773    0_
$w MED00166985 $t The journal of pain $x 1528-8447 $g Roč. 22, č. 10 (2021), s. 1294-1302
856    41
$u https://pubmed.ncbi.nlm.nih.gov/33892152 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220425 $b ABA008
991    __
$a 20220506130759 $b ABA008
999    __
$a ok $b bmc $g 1789657 $s 1163355
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2021 $b 22 $c 10 $d 1294-1302 $e 20210420 $i 1528-8447 $m Journal of pain $n J Pain $x MED00166985
LZP    __
$a Pubmed-20220425

Najít záznam

Citační ukazatele

Možnosti archivace