• Je něco špatně v tomto záznamu ?

Psilocybin-Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience

V. Viktorin, I. Griškova-Bulanova, A. Voicikas, D. Dojčánová, P. Zach, A. Bravermanová, V. Andrashko, F. Tylš, J. Korčák, M. Viktorinová, V. Koudelka, K. Hájková, M. Kuchař, J. Horáček, M. Brunovský, T. Páleníček

. 2022 ; 12 (6) : . [pub] 20220619

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22016960

Grantová podpora
20-25349S; 21-32608S Czech Science Foundation
RVO 00023752 Long-term conceptual development of research organization
NU21-04-00307; NV18-04-00260 Czech Health Research Council
260533/SVV/2021 Specific University Research, Czech Ministry of Education, Youth and Sports

Psilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability to generate gamma activity. Based on previous literature, we studied the impact of psilocybin on 40 Hz ASSR in healthy volunteers. The study was double blind and placebo controlled with a crossover design. A sample of 20 healthy subjects (10M/10F) received psilocybin orally 0.26 mg/kg or placebo. Participants were measured four times in total, one time before ingestion of psilocybin/placebo and one time after ingestion, during the peak of intoxication. A series of 500 ms click trains were used for stimulation. Psilocybin induced a psychedelic effect and decreased 40 Hz ASSR phase-locking index compared to placebo. The extent of the attenuation was related to Cognition and Affect on the Hallucinogen Rating Scale. The current study shows that psilocybin lowers the synchronization level and the amplitude of 40 Hz auditory steady-state responses, which yields further support for the role of gamma oscillations in cognitive processing and its disturbance.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22016960
003      
CZ-PrNML
005      
20220909213813.0
007      
ta
008      
220718s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/jpm12061004 $2 doi
035    __
$a (PubMed)35743788
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Viktorin, Vojtěch $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic $1 https://orcid.org/0000000308012244
245    10
$a Psilocybin-Mediated Attenuation of Gamma Band Auditory Steady-State Responses (ASSR) Is Driven by the Intensity of Cognitive and Emotional Domains of Psychedelic Experience / $c V. Viktorin, I. Griškova-Bulanova, A. Voicikas, D. Dojčánová, P. Zach, A. Bravermanová, V. Andrashko, F. Tylš, J. Korčák, M. Viktorinová, V. Koudelka, K. Hájková, M. Kuchař, J. Horáček, M. Brunovský, T. Páleníček
520    9_
$a Psilocybin is a classical serotoninergic psychedelic that induces cognitive disruptions similar to psychosis. Gamma activity is affected in psychosis and is tightly related to cognitive processing. The 40 Hz auditory steady-state responses (ASSR) are frequently used as indicators to test the ability to generate gamma activity. Based on previous literature, we studied the impact of psilocybin on 40 Hz ASSR in healthy volunteers. The study was double blind and placebo controlled with a crossover design. A sample of 20 healthy subjects (10M/10F) received psilocybin orally 0.26 mg/kg or placebo. Participants were measured four times in total, one time before ingestion of psilocybin/placebo and one time after ingestion, during the peak of intoxication. A series of 500 ms click trains were used for stimulation. Psilocybin induced a psychedelic effect and decreased 40 Hz ASSR phase-locking index compared to placebo. The extent of the attenuation was related to Cognition and Affect on the Hallucinogen Rating Scale. The current study shows that psilocybin lowers the synchronization level and the amplitude of 40 Hz auditory steady-state responses, which yields further support for the role of gamma oscillations in cognitive processing and its disturbance.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Griškova-Bulanova, Inga $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Institute of Biosciences, Vilnius University, 7 Saulėtekio Ave, 10257 Vilnius, Lithuania $1 https://orcid.org/0000000150033300
700    1_
$a Voicikas, Aleksandras $u Institute of Biosciences, Vilnius University, 7 Saulėtekio Ave, 10257 Vilnius, Lithuania
700    1_
$a Dojčánová, Dominika $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
700    1_
$a Zach, Peter $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic
700    1_
$a Bravermanová, Anna $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u First Faculty of Medicine, Charles University, Kateřinská 32, 121 08 Prague, Czech Republic
700    1_
$a Andrashko, Veronika $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
700    1_
$a Tylš, Filip $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
700    1_
$a Korčák, Jakub $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic
700    1_
$a Viktorinová, Michaela $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
700    1_
$a Koudelka, Vlastimil $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $1 https://orcid.org/0000000275537529
700    1_
$a Hájková, Kateřina $u Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic
700    1_
$a Kuchař, Martin, $u Forensic Laboratory of Biologically Active Substances, Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Technická 5, 166 28 Prague, Czech Republic $1 https://orcid.org/0000000276166352 $d 1980- $7 xx0070908
700    1_
$a Horáček, Jiří $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
700    1_
$a Brunovský, Martin $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
700    1_
$a Páleníček, Tomáš $u National Institute of Mental Health, Topolová 748, 250 67 Klecany, Czech Republic $u Third Faculty of Medicine, Charles University, Ruská 2411, 100 00 Prague, Czech Republic
773    0_
$w MED00203320 $t Journal of personalized medicine $x 2075-4426 $g Roč. 12, č. 6 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35743788 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20220718 $b ABA008
991    __
$a 20220909213805 $b ABA008
999    __
$a ind $b bmc $g 1816386 $s 1168202
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 12 $c 6 $e 20220619 $i 2075-4426 $m Journal of personalized medicine $n J. pers. med. $x MED00203320
GRA    __
$a 20-25349S; 21-32608S $p Czech Science Foundation
GRA    __
$a RVO 00023752 $p Long-term conceptual development of research organization
GRA    __
$a NU21-04-00307; NV18-04-00260 $p Czech Health Research Council
GRA    __
$a 260533/SVV/2021 $p Specific University Research, Czech Ministry of Education, Youth and Sports
LZP    __
$a Pubmed-20220718

Najít záznam

Citační ukazatele

Možnosti archivace