• Je něco špatně v tomto záznamu ?

Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase

K. Brejchova, V. Paluchova, M. Brezinova, T. Cajka, L. Balas, T. Durand, M. Krizova, Z. Stranak, O. Kuda

. 2022 ; 388 (-) : 132983. [pub] 20220415

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22017740

Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22017740
003      
CZ-PrNML
005      
20220804134402.0
007      
ta
008      
220720s2022 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.foodchem.2022.132983 $2 doi
035    __
$a (PubMed)35486985
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Brejchova, Kristyna $u Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic
245    10
$a Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase / $c K. Brejchova, V. Paluchova, M. Brezinova, T. Cajka, L. Balas, T. Durand, M. Krizova, Z. Stranak, O. Kuda
520    9_
$a Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.
650    _2
$a studie případů a kontrol $7 D016022
650    _2
$a císařský řez $7 D002585
650    _2
$a kolostrum $x metabolismus $7 D003126
650    _2
$a estery $x metabolismus $7 D004952
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a kojenec $7 D007223
650    _2
$a novorozenec $7 D007231
650    _2
$a laktace $7 D007774
650    _2
$a lipasa $x metabolismus $7 D008049
650    12
$a mateřské mléko $x metabolismus $7 D008895
650    _2
$a kyselina palmitová $x metabolismus $7 D019308
650    _2
$a těhotenství $7 D011247
650    12
$a předčasný porod $x metabolismus $7 D047928
650    _2
$a triglyceridy $x metabolismus $7 D014280
655    _2
$a časopisecké články $7 D016428
700    1_
$a Paluchova, Veronika $u Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic; First Faculty of Medicine, Charles University, Katerinska 1660/32, 12108 Praha, Czech Republic
700    1_
$a Brezinova, Marie $u Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic; First Faculty of Medicine, Charles University, Katerinska 1660/32, 12108 Praha, Czech Republic
700    1_
$a Cajka, Tomas $u Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic
700    1_
$a Balas, Laurence $u Institut des Biomolecules Max Mousseron, University Montpellier, CNRS, ENSCM, Montpellier, France
700    1_
$a Durand, Thierry $u Institut des Biomolecules Max Mousseron, University Montpellier, CNRS, ENSCM, Montpellier, France
700    1_
$a Krizova, Marcela $u Institute for the Care of Mother and Child, Prague, Czech Republic
700    1_
$a Stranak, Zbynek $u Institute for the Care of Mother and Child, Prague, Czech Republic
700    1_
$a Kuda, Ondrej $u Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic. Electronic address: ondrej.kuda@fgu.cas.cz
773    0_
$w MED00001832 $t Food chemistry $x 1873-7072 $g Roč. 388, č. - (2022), s. 132983
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35486985 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20220720 $b ABA008
991    __
$a 20220804134355 $b ABA008
999    __
$a ok $b bmc $g 1821733 $s 1168983
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 388 $c - $d 132983 $e 20220415 $i 1873-7072 $m Food chemistry $n Food chem. $x MED00001832
LZP    __
$a Pubmed-20220720
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace