Radiation resistance of cancer cells represents one of the major challenges in cancer treatment. The novel self-assembled fluoralkylated diselenide nanoparticles (fluorosomes) based on seleno-l-cystine (17FSe2) possess redox-active properties that autocatalytically decompose hydrogen peroxide (H2O2) and oxidize the intracellular glutathione (GSH) that results in regulation of cellular oxidative stress. Alkylfluorinated diselenide nanoparticles showed a significant cytotoxic and radiosensitizing effect on cancer cells. The EL-4 tumor-bearing C56BL/6 mice treated with 17FSe2 followed by fractionated radiation treatment (4 × 2Gy) completely suppressed tumor growth. Our results suggest that described diselenide system behaves as a potent radiosensitizer agent targeting tumor growth and preventing tumor recurrence.

Center for Advanced Preclinical Imaging 1st Faculty of Medicine Charles University Salmovska 3 Prague 2 120 00 Czech Republic

Institute of Macromolecular Chemistry of the Czech Academy of Sciences Heyrovsky Sq 2 162 06 Prague 6 Czech Republic

Stanford University Stanford School of Medicine Stanford CA 94305 USA

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$a Vetrik, Miroslav $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic; Stanford University, Stanford School of Medicine, Stanford, CA, 94305, USA. Electronic address: miroslav.vetrik@gmail.com

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$a Fluorinated diselenide nanoparticles for radiosensitizing therapy of cancer / $c M. Vetrik, J. Kucka, L. Kobera, R. Konefal, V. Lobaz, E. Pavlova, M. Bajecny, T. Heizer, J. Brus, L. Sefc, G. Pratx, M. Hruby

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$a Radiation resistance of cancer cells represents one of the major challenges in cancer treatment. The novel self-assembled fluoralkylated diselenide nanoparticles (fluorosomes) based on seleno-l-cystine (17FSe2) possess redox-active properties that autocatalytically decompose hydrogen peroxide (H2O2) and oxidize the intracellular glutathione (GSH) that results in regulation of cellular oxidative stress. Alkylfluorinated diselenide nanoparticles showed a significant cytotoxic and radiosensitizing effect on cancer cells. The EL-4 tumor-bearing C56BL/6 mice treated with 17FSe2 followed by fractionated radiation treatment (4 × 2Gy) completely suppressed tumor growth. Our results suggest that described diselenide system behaves as a potent radiosensitizer agent targeting tumor growth and preventing tumor recurrence.

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$a Kucka, Jan $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic

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$a Kobera, Libor $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic

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$a Konefal, Rafal $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic

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$a Bajecny, Martin $u Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovska 3, Prague 2, 120 00, Czech Republic

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$a Heizer, Tomas $u Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovska 3, Prague 2, 120 00, Czech Republic

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$a Brus, Jiri $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic

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$a Sefc, Ludek $u Center for Advanced Preclinical Imaging (CAPI), First Faculty of Medicine, Charles University, Salmovska 3, Prague 2, 120 00, Czech Republic

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$a Pratx, Guillem $u Stanford University, Stanford School of Medicine, Stanford, CA, 94305, USA

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$a Hruby, Martin $u Institute of Macromolecular Chemistry of the Czech Academy of Sciences, Heyrovsky Sq.2, 162 06, Prague 6, Czech Republic

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