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The management of membranous nephropathy-an update

F. Caravaca-Fontán, GM. Fernández-Juárez, J. Floege, D. Goumenos, A. Kronbichler, K. Turkmen, C. van Kooten, E. Frangou, KI. Stevens, M. Segelmark, V. Tesar, HJ. Anders, A. Bruchfeld

. 2022 ; 37 (6) : 1033-1042. [pub] 20220525

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc22018325

In recent decades, several important advances have taken place in the understanding of the pathogenesis underlying membranous nephropathy (MN) that have sparked renewed interest in its management. Four landmark trials in MN and a fifth clinical trial-which was a pilot study-have been published in recent years. The results from some of these trials have had a significant impact on the recommendations included in the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for the Management of Glomerular Diseases, representing a significant step forward compared with the previous guideline in several aspects, including diagnosis, disease monitoring and treatment strategies. However, considering the rapidly evolving advances in the knowledge of MN and the recent publication of the STARMEN and RI-CYCLO trials, several recommendations contained in the guideline warrant updates. This article provides a perspective of the Immunonephrology Working Group of the European Renal Association regarding the management of MN in native kidneys of adult patients.

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$a In recent decades, several important advances have taken place in the understanding of the pathogenesis underlying membranous nephropathy (MN) that have sparked renewed interest in its management. Four landmark trials in MN and a fifth clinical trial-which was a pilot study-have been published in recent years. The results from some of these trials have had a significant impact on the recommendations included in the 2021 Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for the Management of Glomerular Diseases, representing a significant step forward compared with the previous guideline in several aspects, including diagnosis, disease monitoring and treatment strategies. However, considering the rapidly evolving advances in the knowledge of MN and the recent publication of the STARMEN and RI-CYCLO trials, several recommendations contained in the guideline warrant updates. This article provides a perspective of the Immunonephrology Working Group of the European Renal Association regarding the management of MN in native kidneys of adult patients.
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$a Fernández-Juárez, Gema M $u Department of Nephrology, Hospital Universitario Fundacion Alcorcon, Alcorcón, Spain
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$a Floege, Jürgen $u Division of Nephrology, RWTH Aachen University Hospital, Aachen, Germany
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$a Goumenos, Dimitrios $u Department of Nephrology and Renal Transplantation, Patras University Hospital, Patras, Greece
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$a Turkmen, Kultigin $u Division of Nephrology, Department of Internal Medicine, Necmettin Erbakan University, Konya, Turkey
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