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An integrative skeletal and paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers
S. Marciniak, CM. Bergey, AM. Silva, A. Hałuszko, M. Furmanek, B. Veselka, P. Velemínský, G. Vercellotti, J. Wahl, G. Zariņa, C. Longhi, J. Kolář, R. Garrido-Pena, R. Flores-Fernández, AM. Herrero-Corral, A. Simalcsik, W. Müller, A. Sheridan, Ž....
Language English Country United States
Document type Historical Article, Journal Article
Grant support
R01-GM115656
HHS | National Institutes of Health (NIH)
NLK
Free Medical Journals
from 1915 to 6 months ago
Freely Accessible Science Journals
from 1915 to 6 months ago
PubMed Central
from 1915 to 6 months ago
Europe PubMed Central
from 1915 to 6 months ago
Open Access Digital Library
from 1915-01-15
Open Access Digital Library
from 1915-01-01
- MeSH
- History, Ancient MeSH
- Child MeSH
- Adult MeSH
- Genetic Variation MeSH
- Genomics MeSH
- Skeleton * anatomy & histology MeSH
- Humans MeSH
- Paleopathology MeSH
- DNA, Ancient MeSH
- Body Height * genetics MeSH
- Health * history MeSH
- Farmers * history MeSH
- Agriculture * history MeSH
- Check Tag
- History, Ancient MeSH
- Child MeSH
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Historical Article MeSH
- Geographicals
- Europe MeSH
Human culture, biology, and health were shaped dramatically by the onset of agriculture ∼12,000 y B.P. This shift is hypothesized to have resulted in increased individual fitness and population growth as evidenced by archaeological and population genomic data alongside a decline in physiological health as inferred from skeletal remains. Here, we consider osteological and ancient DNA data from the same prehistoric individuals to study human stature variation as a proxy for health across a transition to agriculture. Specifically, we compared “predicted” genetic contributions to height from paleogenomic data and “achieved” adult osteological height estimated from long bone measurements for 167 individuals across Europe spanning the Upper Paleolithic to Iron Age (∼38,000 to 2,400 B.P.). We found that individuals from the Neolithic were shorter than expected (given their individual polygenic height scores) by an average of −3.82 cm relative to individuals from the Upper Paleolithic and Mesolithic (P = 0.040) and −2.21 cm shorter relative to post-Neolithic individuals (P = 0.068), with osteological vs. expected stature steadily increasing across the Copper (+1.95 cm relative to the Neolithic), Bronze (+2.70 cm), and Iron (+3.27 cm) Ages. These results were attenuated when we additionally accounted for genome-wide genetic ancestry variation: for example, with Neolithic individuals −2.82 cm shorter than expected on average relative to pre-Neolithic individuals (P = 0.120). We also incorporated observations of paleopathological indicators of nonspecific stress that can persist from childhood to adulthood in skeletal remains into our model. Overall, our work highlights the potential of integrating disparate datasets to explore proxies of health in prehistory.
Archeolodzy org Foundation Wrocław 50 316 Poland
Archeology Center of the University of Lisbon University of Lisbon Lisbon 1600 214 Portugal
Broad Institute of Harvard and Massachusetts Institute of Technology Cambridge MA 02142
Centre for Applied Bioanthropology Institute for Anthropological Research Zagreb 10000 Croatia
Departament d'Història i Història de l'Art Universitat Rovira i Virgili Tarragona 43003 Spain
Department of Anatomy Histology and Anthropology Vilnius University Vilnius 01513 Lithuania
Department of Anthropology Hungarian Natural History Museum Budapest 1083 Hungary
Department of Anthropology National Museum Prague 115 79 Czech Republic
Department of Anthropology Ohio State University Columbus OH 43210
Department of Anthropology Pennsylvania State University University Park PA 16802
Department of Archaeology Déri Múzeum Debrecen 4026 Hungary
Department of Archaeology Herman Ottó Museum Miskolc 3530 Hungary
Department of Archaeology Hungarian National Museum Budapest 1088 Hungary
Department of Archaeology István Dobó Castle Museum Eger 3300 Hungary
Department of Archaeology Satu Mare County Museum Satu Mare 440031 Romania
Department of Biological Anthropology Eötvös Loránd University Budapest 1053 Hungary
Department of Biology Pennsylvania State University University Park PA 16802
Department of Evolutionary Anthropology University of Vienna Vienna 1030 Austria
Department of Genetics Harvard Medical School Boston MA 02115
Department of Human Evolutionary Biology Harvard University Cambridge MA 02138
Department of Prehistory and Archaeology Universidad Autónoma de Madrid Madrid 28049 Spain
Department of Prehistory Universidad Complutense de Madrid Madrid 28040 Spain
Department of Scottish History and Archaeology National Museums Scotland Edinburgh EH1 1JF Scotland
HHMI Harvard Medical School Cambridge MA 02138
Huck Institutes of the Life Sciences Pennsylvania State University University Park PA 16802
Human Evolution and Archaeological Sciences University of Vienna Vienna 1030 Austria
Institut Català de Paleoecologia Humana i Evolució Social Tarragona 43007 Spain
Institute for Research and Learning in Archaeology and Bioarchaeology Columbus OH 43215
Institute of Archaeology and Museology Masaryk University Brno 602 00 Czech Republic
Institute of Archaeology University of Wrocław Wrocław 50 139 Poland
Institute of Latvian History University of Latvia Riga 1050 Latvia
Laboratoire d'archéozoologie Université de Neuchâtel Neuchâtel 2000 Switzerland
Olga Necrasov Center for Anthropological Research Romanian Academy Iasi Branch Iasi 700481 Romania
Orheiul Vechi Cultural Natural Reserve Orhei 3506 Republic of Moldova
Professional archaeologist Parla 28980 Spain
Soprintendenza Archeologia Belle Arti e Paesaggio Rome 00186 Italy
References provided by Crossref.org
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