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Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods

L. Vaníčková, T. Do, M. Vejvodová, V. Horák, M. Hubálek, G. Emri, K. Zemánková, K. Pavelicová, S. Křížková, V. Faltusová, A. Pompeiano, M. Vaculovičová, O. Zítka, T. Vaculovič, V. Adam

. 2022 ; 203 (-) : 583-592. [pub] 20220125

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22018975

Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation of specific melanoma markers and elements and their spatial distribution in tissue sections. MALDI-MSI combined with HPLC-MS/MS analyses resulted in identification of seven specific proteins, S100A12, CD163, MMP-2, galectin-1, tenascin, resistin and PCNA that were presented in the melanoma signatures. Furthermore, the ICP-MS method allowed for spatial detection of zinc, calcium, copper, and iron elements linked with the allocation of the specific binding proteins.

Citace poskytuje Crossref.org

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$a Vaníčková, Lucie $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic; Department of Forest Botany, Dendrology and Geobiocenology, Faculty of Forest and Wood Technology, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic. Electronic address: lucie.vanickova@mendelu.cz
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$a Mapping of MeLiM melanoma combining ICP-MS and MALDI-MSI methods / $c L. Vaníčková, T. Do, M. Vejvodová, V. Horák, M. Hubálek, G. Emri, K. Zemánková, K. Pavelicová, S. Křížková, V. Faltusová, A. Pompeiano, M. Vaculovičová, O. Zítka, T. Vaculovič, V. Adam
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$a Here we developed a powerful tool for comprehensive data collection and mapping of molecular and elemental signatures in the Melanoma-bearing Libechov Minipig (MeLiM) model. The combination of different mass spectrometric methods allowed for detail investigation of specific melanoma markers and elements and their spatial distribution in tissue sections. MALDI-MSI combined with HPLC-MS/MS analyses resulted in identification of seven specific proteins, S100A12, CD163, MMP-2, galectin-1, tenascin, resistin and PCNA that were presented in the melanoma signatures. Furthermore, the ICP-MS method allowed for spatial detection of zinc, calcium, copper, and iron elements linked with the allocation of the specific binding proteins.
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$a Do, Tomáš $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic
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$a Vejvodová, Markéta $u Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 753/5, CZ-625 00 Brno, Czech Republic
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$a Horák, Vratislav $u Institute of Animal Physiology and Genetics, Laboratory of Applied Proteome Analyses, Czech Academy of Sciences, v.v.i., Rumburska 89, CZ-27721 Libechov, Czech Republic
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$a Hubálek, Martin $u Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, v.v.i., Flemingovo nam. 542/2, CZ-16000 Prague, Czech Republic
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$a Emri, Gabriella $u Department of Dermatology, Faculty of Medicine, University of Debrecen, Egyetem ter 1, HU-4031 Debrecen, Hungary
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$a Zemánková, Kristýna $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic
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$a Pavelicová, Kristýna $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic
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$a Křížková, Soňa $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic
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$a Faltusová, Veronika $u Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 753/5, CZ-625 00 Brno, Czech Republic
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$a Pompeiano, Antonio $u Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic; Department of Forest Botany, Dendrology and Geobiocenology, Faculty of Forest and Wood Technology, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic
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$a Vaculovičová, Markéta $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic
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$a Zítka, Ondřej $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic
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$a Vaculovič, Tomáš $u Department of Chemistry, Faculty of Science, Masaryk University, Kamenice 753/5, CZ-625 00 Brno, Czech Republic; Institute of Laboratory Research on Geomaterials, Faculty of Natural Sciences, Comenius University in Bratislava, Mlynska dolina, Ilkovicova 6, SK-84215 Bratislava, Slovakia
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$a Adam, Vojtěch $u Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1665/1, CZ-61300 Brno, Czech Republic; Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, CZ-61200 Brno, Czech Republic
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