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The International Database of Central Arterial Properties for Risk Stratification: Research Objectives and Baseline Characteristics of Participants
LS. Aparicio, QF. Huang, JD. Melgarejo, DM. Wei, L. Thijs, FF. Wei, N. Gilis-Malinowska, CS. Sheng, J. Boggia, TJ. Niiranen, AN. Odili, K. Stolarz-Skrzypek, J. Barochiner, D. Ackermann, K. Kawecka-Jaszcz, V. Tikhonoff, ZY. Zhang, E. Casiglia, K....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, metaanalýza, práce podpořená grantem
Grantová podpora
MC_PC_16095
Medical Research Council - United Kingdom
PubMed
34505630
DOI
10.1093/ajh/hpab139
Knihovny.cz E-zdroje
- MeSH
- analýza pulzové vlny MeSH
- hypertenze * diagnóza epidemiologie MeSH
- kardiovaskulární nemoci * diagnóza epidemiologie MeSH
- krevní tlak fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- průřezové studie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
- práce podpořená grantem MeSH
OBJECTIVE: To address to what extent central hemodynamic measurements, improve risk stratification, and determine outcome-based diagnostic thresholds, we constructed the International Database of Central Arterial Properties for Risk Stratification (IDCARS), allowing a participant-level meta-analysis. The purpose of this article was to describe the characteristics of IDCARS participants and to highlight research perspectives. METHODS: Longitudinal or cross-sectional cohort studies with central blood pressure measured with the SphygmoCor devices and software were included. RESULTS: The database included 10,930 subjects (54.8% women; median age 46.0 years) from 13 studies in Europe, Africa, Asia, and South America. The prevalence of office hypertension was 4,446 (40.1%), of which 2,713 (61.0%) were treated, and of diabetes mellitus was 629 (5.8%). The peripheral and central systolic/diastolic blood pressure averaged 129.5/78.7 mm Hg and 118.2/79.7 mm Hg, respectively. Mean aortic pulse wave velocity was 7.3 m per seconds. Among 6,871 participants enrolled in 9 longitudinal studies, the median follow-up was 4.2 years (5th-95th percentile interval, 1.3-12.2 years). During 38,957 person-years of follow-up, 339 participants experienced a composite cardiovascular event and 212 died, 67 of cardiovascular disease. CONCLUSIONS: IDCARS will provide a unique opportunity to investigate hypotheses on central hemodynamic measurements that could not reliably be studied in individual studies. The results of these analyses might inform guidelines and be of help to clinicians involved in the management of patients with suspected or established hypertension.
Biomedical Sciences Group Faculty of Medicine University of Leuven Leuven Belgium
Department of Chronic Disease Prevention Finnish Institute for Health and Welfare Turku Finland
Department of Medicine University of Padua Padua Italy
Department of Medicine University of Turku and Turku University Hospital Turku Finland
Faculty of Medicine Charles University Pilsen Czech Republic
Institute of Social and Preventive Medicine University Hospital of Lausanne Lausanne Switzerland
Research Institute Alliance for the Promotion of Preventive Medicine Mechelen Belgium
Citace poskytuje Crossref.org
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