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Characterisation of age and polarity at onset in bipolar disorder
JL. Kalman, LM. Olde Loohuis, A. Vreeker, A. McQuillin, EA. Stahl, D. Ruderfer, M. Grigoroiu-Serbanescu, G. Panagiotaropoulou, S. Ripke, TB. Bigdeli, F. Stein, T. Meller, S. Meinert, H. Pelin, F. Streit, S. Papiol, MJ. Adams, R. Adolfsson, K....
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural
Grantová podpora
K99 MH116115
NIMH NIH HHS - United States
R00 MH116115
NIMH NIH HHS - United States
R01 MH104964
NIMH NIH HHS - United States
R01 MH123451
NIMH NIH HHS - United States
NLK
Free Medical Journals
od 2000
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 2000-01-01
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
PubMed
35048876
DOI
10.1192/bjp.2021.102
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha * diagnóza epidemiologie genetika MeSH
- celogenomová asociační studie MeSH
- depresivní porucha unipolární * genetika MeSH
- lidé MeSH
- multifaktoriální dědičnost MeSH
- poruchy autistického spektra * MeSH
- věk při počátku nemoci MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. AIMS: To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. METHOD: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. RESULTS: Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = -0.34 years, s.e. = 0.08), major depression (β = -0.34 years, s.e. = 0.08), schizophrenia (β = -0.39 years, s.e. = 0.08), and educational attainment (β = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. CONCLUSIONS: AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
Alexandru Obregia Clinical Psychiatric Hospital Bucharest Romania
Analytic and Translational Genetics Unit Massachusetts General Hospital USA
Bazil Hetzel Institute Australia
Cell Biology SUNY Downstate Medical Center College of Medicine USA
Center for Mind Brain and Behavior Germany
Centre for Addiction and Mental Health Toronto Canada
Centre for Human Genetics University of Marburg Germany
Centro de Investigación Biomedica en Red de Salud Mental Spain
Dalla Lana School of Public Health Biostatistics Division University of Toronto Canada
Department of Biochemistry and Molecular Biology Indiana University School of Medicine USA
Department of Biomedical Informatics Vanderbilt University Medical Center USA
Department of Biomedicine University of Basel Switzerland
Department of Clinical Neuroscience Centre for Psychiatry Research Karolinska Institutet Sweden
Department of Clinical Sciences Medical Faculty Umeå University Sweden
Department of Genetics and Genomics Icahn School of Medicine at Mount Sinai USA
Department of Health Sciences Research Mayo Clinic USA
Department of Human Genetics University of Chicago USA
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Sweden
Department of Medical Genetics Oslo University Hospital Ullevål Norway
Department of Medicine Surgery and Dentistry 'Scuola Medica Salernitana' University of Salerno Italy
Department of Psychiatric Genetics Poznan University of Medical Sciences Poland
Department of Psychiatric Research Diakonhjemmet Hospital Norway
Department of Psychiatry and Behavioral Neuroscience University of Chicago USA
Department of Psychiatry and Behavioral Sciences Emory University USA
Department of Psychiatry and Behavioral Sciences Howard University Hospital USA
Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of Medicine USA
Department of Psychiatry and Behavioral Sciences Johns Hopkins University USA
Department of Psychiatry and Behavioral Sciences SUNY Downstate Health Sciences University USA
Department of Psychiatry and Behavioral Sciences SUNY Upstate Medical University USA
Department of Psychiatry and Behavioral Sciences Vanderbilt University Medical Center USA
Department of Psychiatry and Psychology Mayo Clinic USA
Department of Psychiatry and Psychotherapeutic Medicine Medical University Graz Austria
Department of Psychiatry and Psychotherapy Charite Universitätsmedizin Germany
Department of Psychiatry and Psychotherapy Philipps University Marburg Germany
Department of Psychiatry and Psychotherapy University Hospital Munich Germany
Department of Psychiatry and Psychotherapy University Medical Center Göttingen Germany
Department of Psychiatry and Trinity Translational Medicine Institute Trinity College Dublin Ireland
Department of Psychiatry Dalhousie University Canada
Department of Psychiatry Geneva University Hospitals Switzerland
Department of Psychiatry Icahn School of Medicine at Mount Sinai USA
Department of Psychiatry McGill University Canada
Department of Psychiatry Melbourne Medical School The University of Melbourne Australia
Department of Psychiatry Psychotherapy and Psychosomatics University Hospital Wurzburg Germany
Department of Psychiatry Rush Medical College USA
Department of Psychiatry Stony Brook University USA
Department of Psychiatry University of California San Diego USA
Department of Psychiatry University of Campania 'Luigi Vanvitelli' Italy
Department of Psychiatry University of Michigan USA
Department of Psychiatry University of Münster Germany
Department of Psychiatry University of Perugia Italy
Department of Psychiatry University of Toronto Canada
Department of Psychiatry University of Toronto Toronto Canada
Department of Translational Research Max Planck Institute of Psychiatry Germany
Discipline of Psychiatry Adelaide Medical School The University of Adelaide Australia
Discipline of Psychiatry University of Adelaide Australia
Division of Mental Health and Addiction Oslo University Hospital Norway
Division of Mental Health and Addiction Oslo University Hosptial Norway
Division of Psychiatric Genomics Mount Sinai School of Medicine USA
Division of Psychiatry University College London UK
Division of Psychiatry University of Edinburgh UK
DMU Neurosciences GHU Lariboisière Fernand Widal Departement de Psychiatrie APHP France
Douglas Institute McGill University Canada
Faculty of medicine University of Geneva Switzerland
Harvard T H Chan School of Public Health USA
Hospital Clinic University of Barcelona IDIBAPS CIBERSAM Spain
Human Genetics Branch Intramural Research Program National Institute of Mental Health USA
Human Genetics University of California Los Angeles USA
INSERM U 955 Neuropsychiatrie Translationnelle France
Institute for Genomic Health SUNY Downstate Medical Center College of Medicine USA
Institute for Translational Neuroscience University of Münster Germany
Institute for Translational Psychiatry Westfälische Wilhelms Universität Münster Germany
Institute of Medical Genetics and Pathology University Hospital Basel Switzerland
Institute of Medical Science University of Toronto Canada
Institute of Neuroscience and Medicine Research Centre Julich Germany
Institute of Psychiatric Phenomics and Genomics University Hospital LMU Munich Germany
Institute of Psychiatry Psychology and Neuroscience Kings College London UK
International Max Planck Research School for Translational Psychiatry Germany
Laboratory Medicine and Pathobiology University of Toronto Canada
Max Planck Institute of Psychiatry Germany
Mental Health Department University Regional Hospital Biomedicine Institute Spain
Montreal Neurological Institute Canada and Department of Neurology McGill University Canada
Mood Disorders Centre of Ottawa Canada
National Institute of Mental Health Czech Republic
Neuroscience Janssen Research and Development USA
Neuroscience Research Australia Australia
NORMENT Centre Division of Mental Health and Addiction Oslo University Hosptial Norway
NORMENT Centre Inst of Clinical Medicine University of Oslo Norway
NORMENT Department of Clinical Science University of Bergen Norway
NORMENT Division of Mental Health and Addiction Oslo University Hospital Norway
Northern Adelaide Mental Health Service SA Health Australia
Nova Scotia Health Authority Canada
Psychiatric Clinic Alexander University Hospital Bulgaria
Psychiatry and the Behavioral Sciences University of Southern California USA
Psychiatry Erasmus University Medical Center the Netherlands
Psychiatry Indiana University School of Medicine USA
Psychiatry UMC Utrecht Brain Center the Netherlands
Psychiatry University of California San Francisco USA
Psychiatry University of Pennsylvania USA
Psychological Medicine University of Worcester UK
Research Institute Lindner Center of HOPE USA
School of Medical Sciences University of New South Wales Australia
School of Psychiatry University of New South Wales Australia
Stanley Center for Psychiatric Research Broad Institute of MIT and Harvard USA
The Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health Canada
The Florey Institute of Neuroscience and Mental Health The University of Melbourne Australia
Translational Genomics USC USA
Unit of Clinical Pharmacology University Hospital Agency of Cagliari Italy
Universite Paris Est Creteil France
Citace poskytuje Crossref.org
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- $a Characterisation of age and polarity at onset in bipolar disorder / $c JL. Kalman, LM. Olde Loohuis, A. Vreeker, A. McQuillin, EA. Stahl, D. Ruderfer, M. Grigoroiu-Serbanescu, G. Panagiotaropoulou, S. Ripke, TB. Bigdeli, F. Stein, T. Meller, S. Meinert, H. Pelin, F. Streit, S. Papiol, MJ. Adams, R. Adolfsson, K. Adorjan, I. Agartz, SR. Aminoff, H. Anderson-Schmidt, OA. Andreassen, R. Ardau, JM. Aubry, C. Balaban, N. Bass, BT. Baune, F. Bellivier, A. Benabarre, S. Bengesser, WH. Berrettini, MP. Boks, EJ. Bromet, K. Brosch, M. Budde, W. Byerley, P. Cervantes, C. Chillotti, S. Cichon, SR. Clark, AL. Comes, A. Corvin, W. Coryell, N. Craddock, DW. Craig, PE. Croarkin, C. Cruceanu, PM. Czerski, N. Dalkner, U. Dannlowski, F. Degenhardt, M. Del Zompo, JR. DePaulo, S. Djurovic, HJ. Edenberg, MA. Eissa, T. Elvsåshagen, B. Etain, AH. Fanous, F. Fellendorf, A. Fiorentino, AJ. Forstner, MA. Frye, JM. Fullerton, K. Gade, J. Garnham, E. Gershon, M. Gill, FS. Goes, K. Gordon-Smith, P. Grof, J. Guzman-Parra, T. Hahn, R. Hasler, M. Heilbronner, U. Heilbronner, S. Jamain, E. Jimenez, I. Jones, L. Jones, L. Jonsson, RS. Kahn, JR. Kelsoe, JL. Kennedy, T. Kircher, G. Kirov, S. Kittel-Schneider, F. Klöhn-Saghatolislam, JA. Knowles, TM. Kranz, TV. Lagerberg, M. Landen, WB. Lawson, M. Leboyer, QS. Li, M. Maj, D. Malaspina, M. Manchia, F. Mayoral, SL. McElroy, MG. McInnis, AM. McIntosh, H. Medeiros, I. Melle, V. Milanova, PB. Mitchell, P. Monteleone, AM. Monteleone, MM. Nöthen, T. Novak, JI. Nurnberger, N. O'Brien, KS. O'Connell, C. O'Donovan, MC. O'Donovan, N. Opel, A. Ortiz, MJ. Owen, E. Pålsson, C. Pato, MT. Pato, J. Pawlak, JK. Pfarr, C. Pisanu, JB. Potash, MH. Rapaport, D. Reich-Erkelenz, A. Reif, E. Reininghaus, J. Repple, H. Richard-Lepouriel, M. Rietschel, K. Ringwald, G. Roberts, G. Rouleau, S. Schaupp, WA. Scheftner, S. Schmitt, PR. Schofield, KO. Schubert, EC. Schulte, B. Schweizer, F. Senner, G. Severino, S. Sharp, C. Slaney, OB. Smeland, JL. Sobell, A. Squassina, P. Stopkova, J. Strauss, A. Tortorella, G. Turecki, J. Twarowska-Hauser, M. Veldic, E. Vieta, JB. Vincent, W. Xu, CC. Zai, PP. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, A. Di Florio, JW. Smoller, JM. Biernacka, FJ. McMahon, M. Alda, B. Müller-Myhsok, N. Koutsouleris, P. Falkai, NB. Freimer, TFM. Andlauer, TG. Schulze, RA. Ophoff
- 520 9_
- $a BACKGROUND: Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools. AIMS: To examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics. METHOD: Genome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts. RESULTS: Earlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = -0.34 years, s.e. = 0.08), major depression (β = -0.34 years, s.e. = 0.08), schizophrenia (β = -0.39 years, s.e. = 0.08), and educational attainment (β = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO. CONCLUSIONS: AAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
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- $a Olde Loohuis, Loes M $u Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA
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- $a Pelin, Helena $u International Max Planck Research School for Translational Psychiatry, Germany; and Max Planck Institute of Psychiatry, Germany
- 700 1_
- $a Streit, Fabian $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany
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- $a Kelsoe, John R $u Department of Psychiatry, University of California San Diego, USA
- 700 1_
- $a Kennedy, James L $u Department of Psychiatry, University of Toronto, Canada; The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; and Institute of Medical Science, University of Toronto, Canada
- 700 1_
- $a Kircher, Tilo $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany
- 700 1_
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- 700 1_
- $a Kittel-Schneider, Sarah $u Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany; and Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital Wurzburg, Germany
- 700 1_
- $a Klöhn-Saghatolislam, Farah $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany
- 700 1_
- $a Knowles, James A $u Cell Biology, SUNY Downstate Medical Center College of Medicine, USA; and Institute for Genomic Health, SUNY Downstate Medical Center College of Medicine, USA
- 700 1_
- $a Kranz, Thorsten M $u Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Germany
- 700 1_
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- 700 1_
- $a Landen, Mikael $u Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Sweden; and Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Sweden
- 700 1_
- $a Lawson, William B $u Department of Psychiatry and Behavioral Sciences, Howard University Hospital, USA
- 700 1_
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- 700 1_
- $a Li, Qingqin S $u Neuroscience, Janssen Research & Development, USA
- 700 1_
- $a Maj, Mario $u Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Italy
- 700 1_
- $a Malaspina, Dolores $u Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA; and Department of Genetics & Genomics, Icahn School of Medicine at Mount Sinai, USA
- 700 1_
- $a Manchia, Mirko $u Unit of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Italy and Department of Pharmacology, Dalhousie University, Canada
- 700 1_
- $a Mayoral, Fermin $u Mental Health Department, University Regional Hospital, Biomedicine Institute (IBIMA), Spain
- 700 1_
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- 700 1_
- $a McInnis, Melvin G $u Department of Psychiatry, University of Michigan, USA
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Monteleone, Alessio Maria $u Department of Psychiatry, University of Campania 'Luigi Vanvitelli', Italy
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Pfarr, Julia-Katharina $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany
- 700 1_
- $a Pisanu, Claudia $u Department of Biomedical Science, Section of Neuroscience & Clinical Pharmacology, University of Cagliari, Italy
- 700 1_
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- 700 1_
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- 700 1_
- $a Reich-Erkelenz, Daniela $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Schaupp, Sabrina $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany
- 700 1_
- $a Scheftner, William A $u Department of Psychiatry, Rush Medical College, USA
- 700 1_
- $a Schmitt, Simon $u Department of Psychiatry and Psychotherapy, Philipps-University Marburg, Germany
- 700 1_
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- 700 1_
- $a Schubert, K Oliver $u Discipline of Psychiatry, University of Adelaide, Australia; and Northern Adelaide Mental Health Service, SA Health, Australia
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Sharp, Sally $u Division of Psychiatry, University College London, UK
- 700 1_
- $a Slaney, Claire $u Nova Scotia Health Authority, Canada
- 700 1_
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- 700 1_
- $a Sobell, Janet L $u Psychiatry and the Behavioral Sciences, University of Southern California, USA
- 700 1_
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- 700 1_
- $a Stopkova, Pavla $u National Institute of Mental Health, Czech Republic
- 700 1_
- $a Strauss, John $u Department of Psychiatry, University of Toronto, Canada; The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; and Institute of Medical Science, University of Toronto, Canada
- 700 1_
- $a Tortorella, Alfonso $u Department of Psychiatry, University of Perugia, Italy
- 700 1_
- $a Turecki, Gustavo $u Department of Psychiatry, McGill University, Canada; and Douglas Institute, McGill University, Canada
- 700 1_
- $a Twarowska-Hauser, Joanna $u Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poland
- 700 1_
- $a Veldic, Marin $u Department of Psychiatry and Psychology, Mayo Clinic, USA
- 700 1_
- $a Vieta, Eduard $u Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Spain
- 700 1_
- $a Vincent, John B $u Department of Psychiatry, University of Toronto, Canada; The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; and Institute of Medical Science, University of Toronto, Canada
- 700 1_
- $a Xu, Wei $u Dalla Lana School of Public Health, Biostatistics Division, University of Toronto, Canada
- 700 1_
- $a Zai, Clement C $u Department of Psychiatry, University of Toronto, Canada; The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Canada; Institute of Medical Science, University of Toronto, Canada; Laboratory Medicine and Pathobiology, University of Toronto, Canada; and Harvard T.H. Chan School of Public Health, USA
- 700 1_
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- 700 1_
- $a Di Florio, Arianna $u Medical Research Council Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, UK
- 700 1_
- $a Smoller, Jordan W $u Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Genomic Medicine, Massachusetts General Hospital, USA; and Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, USA
- 700 1_
- $a Biernacka, Joanna M $u Department of Psychiatry and Psychology, Mayo Clinic, USA; and Department of Health Sciences Research, Mayo Clinic, USA
- 700 1_
- $a McMahon, Francis J $u Human Genetics Branch, Intramural Research Program, National Institute of Mental Health, USA
- 700 1_
- $a Alda, Martin $u National Institute of Mental Health, Czech Republic; and Department of Psychiatry, Dalhousie University, Canada $1 https://orcid.org/0000000195443944
- 700 1_
- $a Müller-Myhsok, Bertram $u Max Planck Institute of Psychiatry, Germany
- 700 1_
- $a Koutsouleris, Nikolaos $u Department of Psychiatry and Psychotherapy, University Hospital Munich, Germany; Max Planck Institute of Psychiatry, Germany; and Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK
- 700 1_
- $a Falkai, Peter $u Department of Psychiatry and Psychotherapy, University Hospital Munich, Germany
- 700 1_
- $a Freimer, Nelson B $u Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA; and Human Genetics, University of California Los Angeles, USA
- 700 1_
- $a Andlauer, Till F M $u Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Germany $1 https://orcid.org/0000000229175889
- 700 1_
- $a Schulze, Thomas G $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Germany; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA; and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, USA
- 700 1_
- $a Ophoff, Roel A $u Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, USA; Human Genetics, University of California Los Angeles, USA; and Psychiatry, Erasmus University Medical Center, the Netherlands
- 710 2_
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- 710 2_
- $a International Consortium on Lithium Genetics (ConLiGen)
- 710 2_
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