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Initial dosing of intermittent vancomycin in adults: estimation of dosing interval in relation to dose and renal function
M. Šíma, J. Hartinger, T. Grus, O. Slanař
European journal of hospital pharmacy.
2021 ;
28 (5) :
276-279.
[pub] 20190807
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc22019675
Online
Plný text
NLK
PubMed Central
od 2016
Europe PubMed Central
od 2016 do Před 1 rokem
ProQuest Central
od 2012-02-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 2012-02-01 do Před 6 měsíci
- MeSH
- antibakteriální látky * MeSH
- dospělí MeSH
- hodnoty glomerulární filtrace MeSH
- ledviny fyziologie MeSH
- lidé MeSH
- monitorování léčiv MeSH
- vankomycin * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
OBJECTIVES Due to the high interindividual variability in vancomycin pharmacokinetics optimisation of its dosing is still challenging This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosing nomogram for initial treatment METHODS Vancomycin pharmacokinetics was calculated in a two compartmental model based on therapeutic drug moni
Citace poskytuje Crossref.org
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- $a Šíma, Martin $u Department of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic martin.sima@lf1.cuni.cz $1 https://orcid.org/000000026541738X $7 xx0222901
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- $a OBJECTIVES: Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosing nomogram for initial treatment. METHODS: Vancomycin pharmacokinetics was calculated in a two-compartmental model based on therapeutic drug $a OBJECTIVES: Due to the high interindividual variability in vancomycin pharmacokinetics, optimisation of its dosing is still challenging. This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosing nomogram for initial treatment. METHODS: Vancomycin pharmacokinetics was calculated in a two-compartmental model based on therapeutic drug monitoring data. A linear regression model was used to explore the relationship between vancomycin elimination half-life and glomerular filtration rate estimated according the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. RESULTS: In the whole study population (n=66), vancomycin volume of distribution, clearance and half-life median (IQR) values were 0.69 (0.58-0.87) L/kg, 0.031 (0.022-0.050) L/h/kg and 14.4 (9.5-25.2) hours, respectively. Vancomycin half-life was associated with glomerular filtration rate (r2=0.4126, p<0.0001) according to the formula: t1/2 (h) = -0.247×eGFRCKD-EPI (mL/min/1.73 m2)+32.89. This relationship was used to construct a dosing nomogram. CONCLUSIONS: We propose an easy-to-use dosing nomogram for vancomycin therapy initiation that allows individualisation of the dosing interval with respect to the administered dose size and functional renal status. $a OBJECTIVES Due to the high interindividual variability in vancomycin pharmacokinetics optimisation of its dosing is still challenging This study aimed to explore vancomycin pharmacokinetics in adult patients and to propose an easy applicable dosing nomogram for initial treatment METHODS Vancomycin pharmacokinetics was calculated in a two compartmental model based on therapeutic drug moni
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