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Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study
B. Mlecnik, T. Torigoe, G. Bindea, B. Popivanova, M. Xu, T. Fujita, S. Hazama, N. Suzuki, H. Nagano, K. Okuno, Y. Hirohashi, T. Furuhata, I. Takemasa, P. Patel, H. Vora, B. Shah, JB. Patel, KN. Rajvik, SJ. Pandya, SN. Shukla, Y. Wang, G. Zhang,...
Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
Grantová podpora
UMRS1138
Society for Immunotherapy of Cancer
UMRS1138
HalioDx
P-direct
Japan Agency for Medical Research and Development
Grants-in-aid for Scientific Research-S
MEXT
NLK
Free Medical Journals
od 2009
PubMed Central
od 2009
Europe PubMed Central
od 2009
ProQuest Central
od 2009-01-01
Open Access Digital Library
od 2009-01-01
Open Access Digital Library
od 2009-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2009
PubMed
36139506
DOI
10.3390/cancers14184346
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10-4.55) p = 0.0269) of the patient's gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27-9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35-5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21-5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39-6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.
Center for Immuno Oncology University Hospital 53100 Siena Italy
Centre de Recherche des Cordeliers Sorbonne Université Université de Paris 75006 Paris France
Curandis New York NY 10583 USA
Department of Biomedical Sciences Humanitas University Pieve Emanuele 20072 Milan Italy
Department of Biostatistics M D Anderson Cancer Center University of Texas Houston TX 77030 USA
Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON M5S 1A8 Canada
Department of Medical Oncology University Hospital of Bern 3010 Bern Switzerland
Department of Medicine and Surgery University of Parma 43125 Parma Italy
Department of Oncology Pathology Karolinska Institutet Karolinska University 17177 Stockholm Sweden
Department of Pathology Cliniques Universitaires St Luc 1200 Brussels Belgium
Department of Pathology Istituto Nazionale Tumori IRCCS Fondazione G Pascale 80131 Naples Italy
Department of Pathology Memorial Sloan Kettering Cancer Center New York NY 10065 USA
Department of Pathology Providence Portland Medical Center Portland OR 97213 USA
Department of Pathology Sapporo Medical University Sapporo 060 8556 Japan
Department of Pathology University Erlangen Nürnberg 91054 Erlangen Germany
Department of Surgery Kindai University School of Medicine Osakasayama 589 0014 Japan
Department of Surgery University Erlangen Nürnberg 91054 Erlangen Germany
Equipe Labellisée Ligue Contre le Cancer 75006 Paris France
Health Science Center of Xi'an Jiaotong University Xi'an 710061 China
INSERM Laboratory of Integrative Cancer Immunology 75006 Paris France
Institute for Cancer Research School of Basic Medical Science Xi'an 710061 China
Institute of Pathology University of Bern 3008 Bern Switzerland
IRCCS Istituto Nazionale Tumori Regina Elena 00128 Rome Italy
Kite Pharma Santa Monica CA 90404 USA
Laboratory of Molecular Gastroenterology IRCCS Humanitas Research Hospital Rozzano 20090 Milan Italy
Pathology Department Radboud University 6500 HC Nijmegen The Netherlands
Princess Margaret Cancer Centre Toronto ON M5G 2C1 Canada
The Gujarat Cancer and Research Institute Asarwa Ahmedabad 380016 India
Citace poskytuje Crossref.org
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- $a Mlecnik, Bernhard $u INSERM, Laboratory of Integrative Cancer Immunology, 75006 Paris, France $u Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, 75006 Paris, France $u Equipe Labellisée Ligue Contre le Cancer, 75006 Paris, France $u Inovarion, 75005 Paris, France $1 0000000233451030
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- $a Clinical Performance of the Consensus Immunoscore in Colon Cancer in the Asian Population from the Multicenter International SITC Study / $c B. Mlecnik, T. Torigoe, G. Bindea, B. Popivanova, M. Xu, T. Fujita, S. Hazama, N. Suzuki, H. Nagano, K. Okuno, Y. Hirohashi, T. Furuhata, I. Takemasa, P. Patel, H. Vora, B. Shah, JB. Patel, KN. Rajvik, SJ. Pandya, SN. Shukla, Y. Wang, G. Zhang, T. Yoshino, H. Taniguchi, C. Bifulco, A. Lugli, JJ. Lee, I. Zlobec, TT. Rau, MD. Berger, ID. Nagtegaal, E. Vink-Börger, A. Hartmann, CI. Geppert, J. Kolwelter, S. Merkel, R. Grützmann, M. Van den Eynde, A. Jouret-Mourin, A. Kartheuser, D. Léonard, C. Remue, J. Wang, P. Bavi, MHA. Roehrl, PS. Ohashi, LT. Nguyen, S. Han, HL. MacGregor, S. Hafezi-Bakhtiari, BG. Wouters, GV. Masucci, E. Andersson, E. Zavadova, M. Vocka, J. Spacek, L. Petruzelka, B. Konopasek, P. Dundr, H. Skalova, K. Nemejcova, G. Botti, F. Tatangelo, P. Delrio, G. Ciliberto, M. Maio, L. Laghi, F. Grizzi, F. Marliot, T. Fredriksen, B. Buttard, L. Lafontaine, P. Maby, A. Majdi, A. Hijazi, C. El Sissy, A. Kirilovsky, A. Berger, C. Lagorce, C. Paustian, C. Ballesteros-Merino, J. Dijkstra, C. Van de Water, S. van Lent-van Vliet, N. Knijn, AM. Mușină, DV. Scripcariu, FM. Marincola, PA. Ascierto, BA. Fox, F. Pagès, Y. Kawakami, J. Galon
- 520 9_
- $a BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I-III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I-III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75-30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10-4.55) p = 0.0269) of the patient's gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27-9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35-5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21-5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39-6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population.
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