• Je něco špatně v tomto záznamu ?

Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient

J. Štingl, J. Hylmarová, M. Lengerová, J. Maláska, J. Stašek

. 2022 ; 12 (8) : . [pub] 20220812

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22023539

Grantová podpora
CZ.02.1.01/0.0/0.0/16_013/0001826 Ministry of Education Youth and Sports
LM2018128 Ministry of Education Youth and Sports
65269705 Ministry of Health

Cryptococcal superinfection is a rare but potentially fatal complication, especially if its detection and subsequent treatment are delayed. Histopathological findings of pulmonary parenchyma from a deceased patient with these complications were acquired. Quite interestingly, only a minimal inflammatory reaction could be seen in an individual with no previously known immune suppression, indicating a disturbance of the immune system. This finding was well in concordance with the described changes in cellular immunity in COVID-19. We report the case of a 60 year old male with critical coronavirus disease 2019 (COVID-19) complicated by cryptococcal pneumonia and multiorgan failure. Both X-ray and CT scans revealed lung infiltrates corresponding with COVID-19 infection early after the onset of symptoms. Despite receiving standard treatment, the patient progressed into multiple organ failure, requiring mechanical ventilation, circulatory support, and haemodialysis. Cryptococcus neoformans was detected by subsequent BAL, and specific antifungal treatment was instituted. His clinical status deteriorated despite all treatment, and he died of refractory circulatory failure after 21 days from hospital admission. Histopathological findings confirmed severe diffuse alveolar damage (DAD) caused by COVID-19 and cryptococcal pneumonia. Timely diagnosis of cryptococcal superinfection may be challenging; therefore, PCR panels detecting even uncommon pathogens should be implemented while taking care of critical COVID-19 patients.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22023539
003      
CZ-PrNML
005      
20221031095255.0
007      
ta
008      
221010s2022 sz f 000 0|eng||
009      
AR
024    7_
$a 10.3390/diagnostics12081944 $2 doi
035    __
$a (PubMed)36010294
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Štingl, Jan $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic
245    10
$a Cryptococcal Pneumonia: An Unusual Complication in a COVID-19 Patient / $c J. Štingl, J. Hylmarová, M. Lengerová, J. Maláska, J. Stašek
520    9_
$a Cryptococcal superinfection is a rare but potentially fatal complication, especially if its detection and subsequent treatment are delayed. Histopathological findings of pulmonary parenchyma from a deceased patient with these complications were acquired. Quite interestingly, only a minimal inflammatory reaction could be seen in an individual with no previously known immune suppression, indicating a disturbance of the immune system. This finding was well in concordance with the described changes in cellular immunity in COVID-19. We report the case of a 60 year old male with critical coronavirus disease 2019 (COVID-19) complicated by cryptococcal pneumonia and multiorgan failure. Both X-ray and CT scans revealed lung infiltrates corresponding with COVID-19 infection early after the onset of symptoms. Despite receiving standard treatment, the patient progressed into multiple organ failure, requiring mechanical ventilation, circulatory support, and haemodialysis. Cryptococcus neoformans was detected by subsequent BAL, and specific antifungal treatment was instituted. His clinical status deteriorated despite all treatment, and he died of refractory circulatory failure after 21 days from hospital admission. Histopathological findings confirmed severe diffuse alveolar damage (DAD) caused by COVID-19 and cryptococcal pneumonia. Timely diagnosis of cryptococcal superinfection may be challenging; therefore, PCR panels detecting even uncommon pathogens should be implemented while taking care of critical COVID-19 patients.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hylmarová, Julie $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $u Department of Pathological Anatomy, University Hospital Brno, 625 00 Brno, Czech Republic
700    1_
$a Lengerová, Martina $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $u Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, 625 00 Brno, Czech Republic
700    1_
$a Maláska, Jan $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital Brno, 625 00 Brno, Czech Republic $u Department of Simulation Medicine, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $1 0000000269112575
700    1_
$a Stašek, Jan $u Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital Brno, 625 00 Brno, Czech Republic $1 0000000283792503
773    0_
$w MED00195450 $t Diagnostics (Basel, Switzerland) $x 2075-4418 $g Roč. 12, č. 8 (2022)
856    41
$u https://pubmed.ncbi.nlm.nih.gov/36010294 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20221010 $b ABA008
991    __
$a 20221031095252 $b ABA008
999    __
$a ind $b bmc $g 1853911 $s 1174827
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 12 $c 8 $e 20220812 $i 2075-4418 $m Diagnostics $n Diagnostics $x MED00195450
GRA    __
$a CZ.02.1.01/0.0/0.0/16_013/0001826 $p Ministry of Education Youth and Sports
GRA    __
$a LM2018128 $p Ministry of Education Youth and Sports
GRA    __
$a 65269705 $p Ministry of Health
LZP    __
$a Pubmed-20221010

Najít záznam

Citační ukazatele

Možnosti archivace