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Protocol for multicentre comparison of interictal high-frequency oscillations as a predictor of seizure freedom
V. Dimakopoulos, J. Gotman, W. Stacey, N. von Ellenrieder, J. Jacobs, C. Papadelis, J. Cimbalnik, G. Worrell, MR. Sperling, M. Zijlmans, L. Imbach, B. Frauscher, J. Sarnthein
Language English Country Great Britain
Document type Journal Article
NLK
Directory of Open Access Journals
from 2019
PubMed Central
from 2019
Oxford Journals Open Access Collection
from 2019-07-01
ROAD: Directory of Open Access Scholarly Resources
from 2019
- Publication type
- Journal Article MeSH
In drug-resistant focal epilepsy, interictal high-frequency oscillations (HFOs) recorded from intracranial EEG (iEEG) may provide clinical information for delineating epileptogenic brain tissue. The iEEG electrode contacts that contain HFO are hypothesized to delineate the epileptogenic zone; their resection should then lead to postsurgical seizure freedom. We test whether our prospective definition of clinically relevant HFO is in agreement with postsurgical seizure outcome. The algorithm is fully automated and is equally applied to all data sets. The aim is to assess the reliability of the proposed detector and analysis approach. We use an automated data-independent prospective definition of clinically relevant HFO that has been validated in data from two independent epilepsy centres. In this study, we combine retrospectively collected data sets from nine independent epilepsy centres. The analysis is blinded to clinical outcome. We use iEEG recordings during NREM sleep with a minimum of 12 epochs of 5 min of NREM sleep. We automatically detect HFO in the ripple (80-250 Hz) and in the fast ripple (250-500 Hz) band. There is no manual rejection of events in this fully automated algorithm. The type of HFO that we consider clinically relevant is defined as the simultaneous occurrence of a fast ripple and a ripple. We calculate the temporal consistency of each patient's HFO rates over several data epochs within and between nights. Patients with temporal consistency <50% are excluded from further analysis. We determine whether all electrode contacts with high HFO rate are included in the resection volume and whether seizure freedom (ILAE 1) was achieved at ≥2 years follow-up. Applying a previously validated algorithm to a large cohort from several independent epilepsy centres may advance the clinical relevance and the generalizability of HFO analysis as essential next step for use of HFO in clinical practice.
Alberta Children's Hospital University of Calgary Calgary Canada
Cook Children's Health Care System Fort Worth TX USA
Department of Neurology Jefferson University Hospitals Philadelphia PA USA
Department of Neurology Mayo Clinic Rochester MN USA
Klinik für Neurochirurgie UniversitätsSpital Zürich Universität Zürich Zürich Switzerland
Montreal Neurological Institute and Hospital McGill University Montreal Quebec Canada
Schweizerisches Epilepsie Zentrum Zurich Switzerland
References provided by Crossref.org
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