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Long-Term Outcomes After Atrial Switch Operation for Transposition of the Great Arteries
CS. Broberg, A. van Dissel, J. Minnier, J. Aboulhosn, RM. Kauling, S. Ginde, EV. Krieger, F. Rodriguez, T. Gupta, S. Shah, AS. John, T. Cotts, WA. Kay, M. Kuo, C. Dwight, P. Woods, J. Nicolarsen, B. Sarubbi, F. Fusco, P. Antonova, S. Fernandes,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
UL1 TR002369
NCATS NIH HHS - United States
NLK
Free Medical Journals
od 1983 do Před 1 rokem
Open Access Digital Library
od 1998-01-01
Elsevier Open Access Journals
od 1983-01-01 do 2023-06-20
Elsevier Open Archive Journals
od 1983-01-01 do Před 1 rokem
- MeSH
- arterie MeSH
- dospělí MeSH
- korekce transpozice velkých arterií * škodlivé účinky MeSH
- lidé MeSH
- následné studie MeSH
- retrospektivní studie MeSH
- srdeční selhání * epidemiologie etiologie MeSH
- transpozice velkých cév * chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
BACKGROUND: For patients with d-loop transposition of the great arteries (d-TGA) with a systemic right ventricle after an atrial switch operation, there is a need to identify risks for end-stage heart failure outcomes. OBJECTIVES: The authors aimed to determine factors associated with survival in a large cohort of such individuals. METHODS: This multicenter, retrospective cohort study included adults with d-TGA and prior atrial switch surgery seen at a congenital heart center. Clinical data from initial and most recent visits were obtained. The composite primary outcome was death, transplantation, or mechanical circulatory support (MCS). RESULTS: From 1,168 patients (38% female, age at first visit 29 ± 7.2 years) during a median 9.2 years of follow-up, 91 (8.8% per 10 person-years) met the outcome (66 deaths, 19 transplantations, 6 MCS). Patients experiencing sudden/arrhythmic death were younger than those dying of other causes (32.6 ± 6.4 years vs 42.4 ± 6.8 years; P < 0.001). There was a long duration between sentinel clinical events and end-stage heart failure. Age, atrial arrhythmia, pacemaker, biventricular enlargement, systolic dysfunction, and tricuspid regurgitation were all associated with the primary outcome. Independent 5-year predictors of primary outcome were prior ventricular arrhythmia, heart failure admission, complex anatomy, QRS duration >120 ms, and severe right ventricle dysfunction based on echocardiography. CONCLUSIONS: For most adults with d-TGA after atrial switch, progress to end-stage heart failure or death is slow. A simplified prediction score for 5-year adverse outcome is derived to help identify those at greatest risk.
Amsterdam University Medical Center Amsterdam the Netherlands
Children's Hospital of Wisconsin Milwaukee Wisconsin USA
Children's Hospital Omaha and University of Nebraska Medical Center Omaha Nebraska USA
Children's National Hospital Washington DC USA
Colorado University School of Medicine Denver Colorado USA
Emory University Hospital Atlanta Georgia USA
Erasmus Medical Center Rotterdam the Netherlands
Green Lane Paediatric and Congenital Cardiac Service Auckland City Hospital Auckland New Zealand
Hospital Universitario Virgen Del Rocio Sevilla Spain
Institute of Medicine Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
Johns Hopkins University Baltimore Maryland USA
Knight Cardiovascular Institute Oregon Health and Science University Portland Oregon USA
Krannert Institute of Cardiology Indianapolis Indiana USA
Montreal Heart Institute Montreal Quebec Canada
Ochsner Medical Center New Orleans Louisiana USA
Providence Spokane Spokane Washington USA
Royal Melbourne Hospital Department of Medicine Melbourne Victoria Australia
Saint Luke's Hospital Kansas City Missouri USA
School of Public Health Oregon Health and Science University Portland Oregon USA
UCLA Medical Center Los Angeles California USA
University Hospital Motol Prague Czech Republic
University of Alberta Edmonton Alberta Canada
University of Michigan Medical Center Ann Arbor Michigan USA
University of Mississippi Medical Center Jackson Mississippi USA
University of Sydney and Royal Prince Alfred Hospital Sydney New South Wales Australia
University of Washington Medical Center and Seattle Children's Hospital Seattle Washington USA
Citace poskytuje Crossref.org
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