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RADIATION DAMAGE TO DNA PLASMIDS IN THE PRESENCE OF BOROCAPTATES
Z. Jamborová, K. Pachnerová Brabcová, A. Jelínek Michaelidesová, O. Zahradníček, I. Danilová, E. Ukraintsev, P. Kundrát, V. Štěpán, M. Davídková
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
CZ.02.1.01/0.0/0.0/16019/0000778
European Regional Development Fund-Project
21-06451S
Czech Science Foundation
PubMed
36005981
DOI
10.1093/rpd/ncac094
Knihovny.cz E-zdroje
- MeSH
- bor * MeSH
- DNA účinky záření MeSH
- plazmidy genetika MeSH
- poškození DNA MeSH
- terapie metodou neutronového záchytu (bor-10) * MeSH
- Publikační typ
- časopisecké články MeSH
Boron derivatives have great potential in cancer diagnostics and treatment. Borocaptates are used in boron neutron capture therapy and potentially in proton boron fusion therapy. This work examines modulation effects of two borocaptate compounds on radiation-induced DNA damage. Aqueous solutions of pBR322 plasmid containing increasing concentrations of borocaptates were irradiated with 60Co gamma rays or 30 MeV protons. Induction of single and double DNA strand breaks was investigated using agarose gel electrophoresis. In this model system, representing DNA without the intervention of cellular repair mechanisms, the boron derivatives acted as antioxidants. Clinically relevant boron concentrations of 40 ppm reduced the DNA single strand breakage seven-fold. Possible mechanisms of the observed effect are discussed.
Citace poskytuje Crossref.org
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