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RADIATION DAMAGE TO DNA PLASMIDS IN THE PRESENCE OF BOROCAPTATES

Z. Jamborová, K. Pachnerová Brabcová, A. Jelínek Michaelidesová, O. Zahradníček, I. Danilová, E. Ukraintsev, P. Kundrát, V. Štěpán, M. Davídková

. 2022 ; 198 (9-11) : 532-536. [pub] 2022Aug22

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22024771

Grantová podpora
CZ.02.1.01/0.0/0.0/16019/0000778 European Regional Development Fund-Project
21-06451S Czech Science Foundation

Boron derivatives have great potential in cancer diagnostics and treatment. Borocaptates are used in boron neutron capture therapy and potentially in proton boron fusion therapy. This work examines modulation effects of two borocaptate compounds on radiation-induced DNA damage. Aqueous solutions of pBR322 plasmid containing increasing concentrations of borocaptates were irradiated with 60Co gamma rays or 30 MeV protons. Induction of single and double DNA strand breaks was investigated using agarose gel electrophoresis. In this model system, representing DNA without the intervention of cellular repair mechanisms, the boron derivatives acted as antioxidants. Clinically relevant boron concentrations of 40 ppm reduced the DNA single strand breakage seven-fold. Possible mechanisms of the observed effect are discussed.

Citace poskytuje Crossref.org

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