Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Multidrug-resistant bacteria in urine culture among patients with spinal cord injury and disorder: Time to first detection and analysis of risk factors

V. Šámal, V. Paldus, D. Fáčková, J. Mečl

. 2022 ; 60 (8) : 733-738. [pub] 20220223

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22025119
E-zdroje Online Plný text

NLK ProQuest Central od 2000-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest) od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem

STUDY DESIGN: Retrospective cohort study. OBJECTIVES: The aim of this study was to assess the time to first detection of multidrug-resistant bacteria (MDRB) in urine culture and identify risk factors associated with the first detection of MDRB (1st MDRB). SETTING: Spinal Care Ward and Department of Microbiology, Regional Hospital Liberec a.s., Liberec, Czech Republic. METHOD: We cultured urine samples from patients in the acute phase of spinal cord injury or disorder (SCI/D). Multidrug resistance (MDR) was defined as acquired nonsusceptibility to at least one agent from three or more antimicrobial categories. Multivariate logistic regression was used to assess the association of bladder management, broad-spectrum antibiotic exposure, mechanical ventilation, pressure ulcers, positive urine culture on admission, and other risk factors with 1st MDRB. We used only the first urine culture with MDRB for evaluation. RESULTS: A total of 655 urine cultures from 246 individuals were evaluated, and 829 isolates were obtained. The MDRB prevalence among all isolates was 40.2%. MDRB was detected in 146 (59.3%) patients for the first time, and 76.0% of these isolates were from patients with asymptomatic bacteriuria. The median time to 1st MDRB was 37 days (95% CI, 33-41). According to multivariate logistic regression, 1st MDRB was associated with bladder management with urethral or suprapubic catheterization (OR: 2.8, 95% CI, 1.1-7.2). CONCLUSION: The prevalence of infections caused by MDRB was high among the SCI/D population, with three-quarters from patients with asymptomatic bacteriuria. Bladder management with an indwelling catheter is associated with an increased risk of 1st MDRB.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc22025119
003      
CZ-PrNML
005      
20221031100230.0
007      
ta
008      
221017s2022 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41393-022-00774-1 $2 doi
035    __
$a (PubMed)35197573
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Šámal, Vladimír $u Department of Urology, Regional Hospital Liberec a.s., Liberec, Czech Republic. vladimir.samal@nemlib.cz $u Department of Urology, Medical Faculty Charles University, Hradec Králové, Czech Republic. vladimir.samal@nemlib.cz $1 https://orcid.org/0000000200819986
245    10
$a Multidrug-resistant bacteria in urine culture among patients with spinal cord injury and disorder: Time to first detection and analysis of risk factors / $c V. Šámal, V. Paldus, D. Fáčková, J. Mečl
520    9_
$a STUDY DESIGN: Retrospective cohort study. OBJECTIVES: The aim of this study was to assess the time to first detection of multidrug-resistant bacteria (MDRB) in urine culture and identify risk factors associated with the first detection of MDRB (1st MDRB). SETTING: Spinal Care Ward and Department of Microbiology, Regional Hospital Liberec a.s., Liberec, Czech Republic. METHOD: We cultured urine samples from patients in the acute phase of spinal cord injury or disorder (SCI/D). Multidrug resistance (MDR) was defined as acquired nonsusceptibility to at least one agent from three or more antimicrobial categories. Multivariate logistic regression was used to assess the association of bladder management, broad-spectrum antibiotic exposure, mechanical ventilation, pressure ulcers, positive urine culture on admission, and other risk factors with 1st MDRB. We used only the first urine culture with MDRB for evaluation. RESULTS: A total of 655 urine cultures from 246 individuals were evaluated, and 829 isolates were obtained. The MDRB prevalence among all isolates was 40.2%. MDRB was detected in 146 (59.3%) patients for the first time, and 76.0% of these isolates were from patients with asymptomatic bacteriuria. The median time to 1st MDRB was 37 days (95% CI, 33-41). According to multivariate logistic regression, 1st MDRB was associated with bladder management with urethral or suprapubic catheterization (OR: 2.8, 95% CI, 1.1-7.2). CONCLUSION: The prevalence of infections caused by MDRB was high among the SCI/D population, with three-quarters from patients with asymptomatic bacteriuria. Bladder management with an indwelling catheter is associated with an increased risk of 1st MDRB.
650    _2
$a antibakteriální látky $x terapeutické užití $7 D000900
650    _2
$a Bacteria $7 D001419
650    12
$a bakteriurie $x komplikace $x diagnóza $x farmakoterapie $7 D001437
650    _2
$a lidé $7 D006801
650    _2
$a retrospektivní studie $7 D012189
650    _2
$a rizikové faktory $7 D012307
650    12
$a poranění míchy $x komplikace $x diagnóza $x epidemiologie $7 D013119
655    _2
$a časopisecké články $7 D016428
700    1_
$a Paldus, Vít $u Department of Urology, Medical Faculty Charles University, Hradec Králové, Czech Republic $1 https://orcid.org/0000000211098336
700    1_
$a Fáčková, Daniela $u Department of Microbiology, Regional Hospital Liberec a.s., Liberec, Czech Republic
700    1_
$a Mečl, Jan $u Department of Urology, Regional Hospital Liberec a.s., Liberec, Czech Republic $1 https://orcid.org/0000000235090988
773    0_
$w MED00006900 $t Spinal cord $x 1476-5624 $g Roč. 60, č. 8 (2022), s. 733-738
856    41
$u https://pubmed.ncbi.nlm.nih.gov/35197573 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y p $z 0
990    __
$a 20221017 $b ABA008
991    __
$a 20221031100228 $b ABA008
999    __
$a ok $b bmc $g 1854693 $s 1176409
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2022 $b 60 $c 8 $d 733-738 $e 20220223 $i 1476-5624 $m Spinal cord $n Spinal Cord $x MED00006900
LZP    __
$a Pubmed-20221017

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...