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Outcomes of SARS-CoV-2 infection among children and young people with pre-existing rheumatic and musculoskeletal diseases

L. Kearsley-Fleet, ML. Chang, S. Lawson-Tovey, R. Costello, Š. Fingerhutová, N. Švestková, A. Belot, FA. Aeschlimann, I. Melki, I. Koné-Paut, S. Eulert, T. Kallinich, Y. Berkun, Y. Uziel, B. Raffeiner, F. Oliveira Ramos, D. Clemente, C....

. 2022 ; 81 (7) : 998-1005. [pub] 20220325

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc22025293

Grantová podpora
UL1 TR002535 NCATS NIH HHS - United States
Department of Health - United Kingdom

OBJECTIVES: Some adults with rheumatic and musculoskeletal diseases (RMDs) are at increased risk of COVID-19-related death. Excluding post-COVID-19 multisystem inflammatory syndrome of children, children and young people (CYP) are overall less prone to severe COVID-19 and most experience a mild or asymptomatic course. However, it is unknown if CYP with RMDs are more likely to have more severe COVID-19. This analysis aims to describe outcomes among CYP with underlying RMDs with COVID-19. METHODS: Using the European Alliance of Associations for Rheumatology COVID-19 Registry, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry, and the CARRA-sponsored COVID-19 Global Paediatric Rheumatology Database, we obtained data on CYP with RMDs who reported SARS-CoV-2 infection (presumptive or confirmed). Patient characteristics and illness severity were described, and factors associated with COVID-19 hospitalisation were investigated. RESULTS: 607 CYP with RMDs <19 years old from 25 different countries with SARS-CoV-2 infection were included, the majority with juvenile idiopathic arthritis (JIA; n=378; 62%). Forty-three (7%) patients were hospitalised; three of these patients died. Compared with JIA, diagnosis of systemic lupus erythematosus, mixed connective tissue disease, vasculitis, or other RMD (OR 4.3; 95% CI 1.7 to 11) or autoinflammatory syndrome (OR 3.0; 95% CI 1.1 to 8.6) was associated with hospitalisation, as was obesity (OR 4.0; 95% CI 1.3 to 12). CONCLUSIONS: This is the most significant investigation to date of COVID-19 in CYP with RMDs. It is important to note that the majority of CYP were not hospitalised, although those with severe systemic RMDs and obesity were more likely to be hospitalised.

Atrius Health Inc Newton Massachusetts USA

Centre for Epidemiology Versus Arthritis Manchester Academic Health Science Centre The University of Manchester Manchester UK

Centre for Genetics and Genomics Versus Arthritis The University of Manchester Manchester UK

Centre for Rheumatology and Department of Neuromuscular Diseases University College London London UK

Clinical Affairs Committee Pediatric Rheumatology European Society Geneva Switzerland

Computational Health Informatics Program Boston Children's Hospital Boston Massachusetts USA

Department of Pediatrics and Adolescent Medicine Charles University Prague and General University Hospital Prague Czech Republic

Department of Pediatrics Division of Pneumonology and Immunology with intensive Medicine Charité Universitätsmedizin Berlin Berlin Germany

Department of Pediatrics Hadassah Hebrew University Medical Center Jerusalem Mount Scopus Israel

Department of Rheumatology Central Hospital of Bolzano Bolzano Italy

Department of Rheumatology Sahlgrenska University Hospital Goteborg Sweden

Epidemiology Unit German Rheumatism Research Center Berlin Berlin Germany

European Reference Network RITA Utrecht Netherlands

Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel

General Pediatrics Infectious Disease and Internal Medicine Department AP HP Hôpital Robert Debré Reims France

National Institute for Health Research University College London Hospitals Biomedical Research Centre University College London Hospitals NHS Foundation Trust London UK

National Institute of Health Research Manchester Biomedical Research Centre Centre for Musculoskeletal Research Manchester University NHS Foundation Trust Manchester UK

National Institute of Health Research Manchester Biomedical Research Centre Manchester Academic Health Science Centre Manchester University NHS Foundation Trust Manchester UK

Paediatric Rheumatology Unit Department of Paediatrics Sackler School of Medicine Tel Aviv University Meir Medical Center Tel Aviv Israel

Paediatric Rheumatology Unit Hospital Infantil Universitario Niño Jesús Madrid Spain

Pediatric Hematology Immunology and Rheumatology Department AP HP Hôpital universitaire Necker Enfants malades Paris France

Pediatric Nephrology Rheumatology and Dermatology Department HFME Université Lyon 1 Hospices Civils de Lyon Lyon France

Pediatrics University Medical Center Utrecht Utrecht The Netherlands

Portuguese League Against Rheumatic Diseases Lisbon Portugal

Rheumatology Department Centro Hospitalar Universitário Lisboa Norte EPE Lisboa Portugal

Service de Rhumatologie Pédiatrique Centre de Référence des Maladies Auto Inflammatoires de l'enfant Centre Hospitalier Universitaire de Bicêtre Paris France

Standing Committee of People with Arthritis Rheumatism in Europe Kilchberg Switzerland

Citace poskytuje Crossref.org

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