-
Je něco špatně v tomto záznamu ?
Endoscopic Postoperative Recurrence in Crohn's Disease After Curative Ileocecal Resection with Early Prophylaxis by Anti-TNF, Vedolizumab or Ustekinumab: A Real-World Multicentre European Study
H. Yanai, A. Kagramanova, O. Knyazev, J. Sabino, S. Haenen, GJ. Mantzaris, K. Mountaki, A. Armuzzi, D. Pugliese, F. Furfaro, G. Fiorino, D. Drobne, T. Kurent, S. Yassin, N. Maharshak, F. Castiglione, R. de Sire, OM. Nardone, K. Farkas, T. Molnar,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu multicentrická studie, časopisecké články
PubMed
35895074
DOI
10.1093/ecco-jcc/jjac100
Knihovny.cz E-zdroje
- MeSH
- biologické přípravky * terapeutické užití MeSH
- Crohnova nemoc * farmakoterapie prevence a kontrola chirurgie MeSH
- dospělí MeSH
- inhibitory TNF terapeutické užití MeSH
- lidé MeSH
- mladý dospělý MeSH
- retrospektivní studie MeSH
- ustekinumab terapeutické užití MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
BACKGROUND: Endoscopic-post-operative-recurrence [ePOR] in Crohn's disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and to compare anti-tumour necrosis factor [anti-TNF] therapy to vedolizumab [VDZ] and ustekinumab [UST] in a real-world setting. METHODS: A retrospective multicentre study of CD-adults after curative ICR on early prophylaxis was undertaken. ePOR was defined as a Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD ≥ 6. Multivariable logistic regression was used to evaluate risk factors, and inverse probability treatment weighting [IPTW] was applied to compare the effectiveness between agents. RESULTS: The study included 297 patients (53.9% males, age at diagnosis 24 years [19-32], age at ICR 34 years [26-43], 18.5% smokers, 27.6% biologic-naïve, 65.7% anti-TNF experienced, 28.6% two or more biologics and 17.2% previous surgery). Overall, 224, 39 and 34 patients received anti-TNF, VDZ or UST, respectively. Patients treated with VDZ and UST were more biologic experienced with higher rates of previous surgery. ePOR rates within 1 year were 41.8%. ePOR rates by treatment groups were: anti-TNF 40.2%, VDZ 33% and UST 61.8%. Risk factors for ePOR at 1 year were: past-infliximab (adjusted odds ratio [adj.OR] = 1.73 [95% confidence interval, CI: 1.01-2.97]), past-adalimumab [adj.OR = 2.32 [95% CI: 1.35-4.01] and surgical aspects. After IPTW, the risk of ePOR within 1 year of VDZ vs anti-TNF or UST vs anti-TNF was comparable (OR = 0.55 [95% CI: 0.25-1.19], OR = 1.86 [95% CI: 0.79-4.38]), respectively. CONCLUSION: Prevention of ePOR within 1 year after surgery was successful in ~60% of patients. Patients treated with VDZ or UST consisted of a more refractory group. After controlling for confounders, no differences in ePOR risk were seen between anti-TNF prophylaxis and other groups.
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Madrid Spain
Concord Medical Center Clalit Health Services Bnei Brak Israel
Department of Clinical Medicine and Surgery University of Naples Federico 2 Naples Italy
Department of Gastroenterology and Hepatology Kaplan Medical Center Rehovot Israel
Department of Gastroenterology and Liver Diseases Tel Aviv Medical Center Tel Aviv Israel
Department of Gastroenterology Austin Hospital Melbourne VIC Australia
Department of Gastroenterology Faculty of Medicine and Health Örebro University Örebro Sweden
Department of Gastroenterology GHA 'Evaggelismos Ophthalmiatreion Athinon Polykliniki' Athens Greece
Department of Gastroenterology Hepatology and Nutrition University Hospital Centre Zagreb Croatia
Department of Gastroenterology Metaxa Memorial General Hospital Piraeus Greece
Department of Gastroenterology Rambam Health Care Campus Haifa Israel
Department of Gastroenterology Sheba Medical Center Tel Hashomer Israel
Department of Gastroenterology St Vincent's Hospital Melbourne VIC Australia
Department of Gastroenterology University Hospitals of Leuven Leuven Belgium
Department of Gastroenterology University Medical Centre Ljubljana Ljubljana Slovenia
Department of Gastroenterology Venizeleio General Hospital Heraklion Crete Greece
Department of Gastroenterology with IBD Unit Clinical Hospital No 2 Rzeszów Poland
Department of Internal Medicine and Pediatrics Ghent University Ghent Belgium
Department of Internal Medicine Medical Faculty University of Ljubljana Ljubljana Slovenia
Department of Medical Sciences University of Turin Turin Italy
Department of Medicine University of Melbourne Melbourne VIC Australia
Department of Medicine University of Szeged Szeged Hungary
Department of Public Health University of Naples Federico 2 Naples Italy
Digestive Diseases Institute Shaare Zedek Medical Center Jerusalem Israel
Division of Gastroenterology Hospital Beatriz Ângelo Loures Lisbon Portugal
Division of Gastroenterology Hospital da Luz Lisboa Portugal
Division of Gastroenterology Mater Dei Hospital Msida Malta
Division of Gastroenterology Rabin Medical Center Petah Tikva Israel
European Reference Network on Hepatological Diseases San Gerardo Hospital Monza Italy
Faculty of Medicine Hebrew University Jerusalem Israel
Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel
Gastroenterology Department Hospital de Bellvitge and IDIBELL L'Hospitalet Spain
Gastroenterology Department University Hospital of Heraklion Crete Greece
Gastroenterology Unit Department of Systems Medicine University of Rome Tor Vergata Italy
Gastroenterology Unit Rho Hospital ASST Rhodense Rho Italy
IBD Center Humanitas Research Hospital IRCCS Milan Italy
IBD Center IRCCS Humanitas Research Hospital Rozzano Milan Italy
IBD unit Department of Gastroenterology University Hospital Ghent Ghent Belgium
Institute of Gastroenterology Meir Hospital Sapir Medical Center Kfar Saba Israel
Irkutsk Scientific Center of Surgery and Traumatology Russia
Moscow Clinical Scientific Centre named after A S Loginov Moscow Russian Federation
Rappaport Faculty of Medicine The Technion Israel Institute of Technology Haifa Israel
Research Institute of Health Organization and Medical Management Moscow Russian Federation
Sackler Faculty of Medicine Tel Aviv University Israel
State Scientific Centre of Coloproctology named after A N Ryzhyh Moscow Russian Federation
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22032250
- 003
- CZ-PrNML
- 005
- 20230131151539.0
- 007
- ta
- 008
- 230120s2022 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1093/ecco-jcc/jjac100 $2 doi
- 035 __
- $a (PubMed)35895074
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Yanai, Henit $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 245 10
- $a Endoscopic Postoperative Recurrence in Crohn's Disease After Curative Ileocecal Resection with Early Prophylaxis by Anti-TNF, Vedolizumab or Ustekinumab: A Real-World Multicentre European Study / $c H. Yanai, A. Kagramanova, O. Knyazev, J. Sabino, S. Haenen, GJ. Mantzaris, K. Mountaki, A. Armuzzi, D. Pugliese, F. Furfaro, G. Fiorino, D. Drobne, T. Kurent, S. Yassin, N. Maharshak, F. Castiglione, R. de Sire, OM. Nardone, K. Farkas, T. Molnar, Z. Krznaric, M. Brinar, E. Chashkova, M. Livne Margolin, U. Kopylov, C. Bezzio, A. Bar-Gil Shitrit, M. Lukas, M. Chaparro, M. Truyens, S. Nancey, T. Lobaton, JP. Gisbert, S. Saibeni, P. Bacsúr, P. Bossuyt, J. Schulberg, F. Hoentjen, C. Viganò, A. Palermo, J. Torres, J. Revés, K. Karmiris, M. Velegraki, E. Savarino, P. Markopoulos, E. Tsironi, P. Ellul, C. Calviño Suárez, R. Weisshof, D. Ben-Hur, T. Naftali, C. Eriksson, IE. Koutroubakis, K. Foteinogiannopoulou, JK. Limdi, E. Liu, G. Surís, E. Calabrese, F. Zorzi, R. Filip, DG. Ribaldone, Y. Snir, I. Goren, H. Banai-Eran, Y. Broytman, H. Amir Barak, I. Avni-Biron, JE. Ollech, I. Dotan, M. Aharoni Golan
- 520 9_
- $a BACKGROUND: Endoscopic-post-operative-recurrence [ePOR] in Crohn's disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and to compare anti-tumour necrosis factor [anti-TNF] therapy to vedolizumab [VDZ] and ustekinumab [UST] in a real-world setting. METHODS: A retrospective multicentre study of CD-adults after curative ICR on early prophylaxis was undertaken. ePOR was defined as a Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD ≥ 6. Multivariable logistic regression was used to evaluate risk factors, and inverse probability treatment weighting [IPTW] was applied to compare the effectiveness between agents. RESULTS: The study included 297 patients (53.9% males, age at diagnosis 24 years [19-32], age at ICR 34 years [26-43], 18.5% smokers, 27.6% biologic-naïve, 65.7% anti-TNF experienced, 28.6% two or more biologics and 17.2% previous surgery). Overall, 224, 39 and 34 patients received anti-TNF, VDZ or UST, respectively. Patients treated with VDZ and UST were more biologic experienced with higher rates of previous surgery. ePOR rates within 1 year were 41.8%. ePOR rates by treatment groups were: anti-TNF 40.2%, VDZ 33% and UST 61.8%. Risk factors for ePOR at 1 year were: past-infliximab (adjusted odds ratio [adj.OR] = 1.73 [95% confidence interval, CI: 1.01-2.97]), past-adalimumab [adj.OR = 2.32 [95% CI: 1.35-4.01] and surgical aspects. After IPTW, the risk of ePOR within 1 year of VDZ vs anti-TNF or UST vs anti-TNF was comparable (OR = 0.55 [95% CI: 0.25-1.19], OR = 1.86 [95% CI: 0.79-4.38]), respectively. CONCLUSION: Prevention of ePOR within 1 year after surgery was successful in ~60% of patients. Patients treated with VDZ or UST consisted of a more refractory group. After controlling for confounders, no differences in ePOR risk were seen between anti-TNF prophylaxis and other groups.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a biologické přípravky $x terapeutické užití $7 D001688
- 650 12
- $a Crohnova nemoc $x farmakoterapie $x prevence a kontrola $x chirurgie $7 D003424
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a výsledek terapie $7 D016896
- 650 _2
- $a inhibitory TNF $x terapeutické užití $7 D000079424
- 650 _2
- $a ustekinumab $x terapeutické užití $7 D000069549
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a multicentrická studie $7 D016448
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kagramanova, Anna $u Moscow Clinical Scientific Centre named after. A.S. Loginov, Moscow, Russian Federation
- 700 1_
- $a Knyazev, Oleg $u Moscow Clinical Scientific Centre named after. A.S. Loginov, Moscow, Russian Federation $u State Scientific Centre of Coloproctology named after A.N. Ryzhyh, Moscow, Russian Federation $u Research Institute of Health Organization and Medical Management, Moscow, Russian Federation
- 700 1_
- $a Sabino, João $u Department of Gastroenterology, University Hospitals of Leuven, Leuven, Belgium
- 700 1_
- $a Haenen, Shana $u Department of Gastroenterology, University Hospitals of Leuven, Leuven, Belgium
- 700 1_
- $a Mantzaris, Gerassimos J $u Department of Gastroenterology, GHA 'Evaggelismos-Ophthalmiatreion Athinon-Polykliniki', Athens, Greece
- 700 1_
- $a Mountaki, Katerina $u Department of Gastroenterology, GHA 'Evaggelismos-Ophthalmiatreion Athinon-Polykliniki', Athens, Greece
- 700 1_
- $a Armuzzi, Alessandro $u IBD Center, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy
- 700 1_
- $a Pugliese, Daniela $u CEMAD, IBD UNIT, Unità Operativa Complessa di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Rome, Italy
- 700 1_
- $a Furfaro, Federica $u IBD Center, Humanitas Research Hospital-IRCCS, Milan, Italy
- 700 1_
- $a Fiorino, Gionata $u Gastroenterology and Endoscopy, IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy $1 https://orcid.org/0000000156232968
- 700 1_
- $a Drobne, David $u Department of Internal Medicine, Medical Faculty, University of Ljubljana, Ljubljana, Slovenia $u Department of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia $1 https://orcid.org/000000032734675X
- 700 1_
- $a Kurent, Tina $u Department of Gastroenterology, University Medical Centre Ljubljana, Ljubljana, Slovenia
- 700 1_
- $a Yassin, Sharif $u Sackler Faculty of Medicine, Tel Aviv University, Israel $u Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv, Israel
- 700 1_
- $a Maharshak, Nitsan $u Sackler Faculty of Medicine, Tel Aviv University, Israel $u Department of Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Tel Aviv, Israel
- 700 1_
- $a Castiglione, Fabiana $u Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
- 700 1_
- $a de Sire, Roberto $u Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy $1 https://orcid.org/0000000264482649
- 700 1_
- $a Nardone, Olga Maria $u Department of Public Health, University of Naples Federico II, Naples, Italy
- 700 1_
- $a Farkas, Klaudia $u Department of Medicine, University of Szeged, Szeged, Hungary
- 700 1_
- $a Molnar, Tamas $u Department of Medicine, University of Szeged, Szeged, Hungary $1 https://orcid.org/0000000238429094
- 700 1_
- $a Krznaric, Zeljko $u Department of Gastroenterology, Hepatology and Nutrition, University Hospital Centre, Zagreb, Croatia
- 700 1_
- $a Brinar, Marko $u Department of Gastroenterology, Hepatology and Nutrition, University Hospital Centre, Zagreb, Croatia
- 700 1_
- $a Chashkova, Elena $u Irkutsk Scientific Center of Surgery and Traumatology, Russia
- 700 1_
- $a Livne Margolin, Moran $u Sackler Faculty of Medicine, Tel Aviv University, Israel $u Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel
- 700 1_
- $a Kopylov, Uri $u Sackler Faculty of Medicine, Tel Aviv University, Israel $u Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel
- 700 1_
- $a Bezzio, Cristina $u Gastroenterology Unit, Rho Hospital, ASST Rhodense, Rho (MI), Italy
- 700 1_
- $a Bar-Gil Shitrit, Ariella $u Digestive Diseases Institute, Shaare Zedek Medical Center, Jerusalem, Israel $u Faculty of Medicine, Hebrew University, Jerusalem, Israel
- 700 1_
- $a Lukas, Milan $u Clinical and Research Centre for Inflammatory Bowel Disease, ISCARE Clinical Centre, Prague, Czech Republic $u Institute of Medical Biochemistry and Laboratory Medicine, General University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Chaparro, María $u Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS- Princesa), Universidad Autónoma de Madrid (UAM), Spain $u Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain $1 https://orcid.org/0000000292754242
- 700 1_
- $a Truyens, Marie $u IBD unit, Department of Gastroenterology, University Hospital Ghent, Ghent, Belgium $u Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- 700 1_
- $a Nancey, Stéphane $u Department of Gastroenterology, Lyon-Sud hospital, Hospices Civils de Lyon, Lyon and INSERM U1111, CIRI, Lyon, France
- 700 1_
- $a Lobaton, Triana $u IBD unit, Department of Gastroenterology, University Hospital Ghent, Ghent, Belgium $u Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- 700 1_
- $a Gisbert, Javier P $u Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa (IIS- Princesa), Universidad Autónoma de Madrid (UAM), Spain $u Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, Spain
- 700 1_
- $a Saibeni, Simone $u Gastroenterology Unit, Rho Hospital, ASST Rhodense, Rho (MI), Italy $1 https://orcid.org/0000000156772534
- 700 1_
- $a Bacsúr, Péter $u Department of Medicine, University of Szeged, Szeged, Hungary
- 700 1_
- $a Bossuyt, Peter $u Imelda GI clinical Research Center, Department of Gastroenterology, Imelda General Hospital, Bonheiden, Belgium $1 https://orcid.org/0000000340277365
- 700 1_
- $a Schulberg, Julien $u Department of Gastroenterology, St Vincent's Hospital, Melbourne, VIC, Australia $u Department of Medicine, University of Melbourne, Melbourne, VIC, Australia $u Department of Gastroenterology, Austin Hospital, Melbourne, VIC, Australia
- 700 1_
- $a Hoentjen, Frank $u Inflammatory Bowel Disease Center, Department of Gastroenterology, Radboud University Medical Center, Nijmegen, The Netherlands and Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, Canada
- 700 1_
- $a Viganò, Chiara $u Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy $u European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy
- 700 1_
- $a Palermo, Andrea $u Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy $u European Reference Network on Hepatological Diseases (ERN RARE-LIVER), San Gerardo Hospital, Monza, Italy
- 700 1_
- $a Torres, Joana $u Division of Gastroenterology, Hospital da Luz Lisboa, Portugal $u Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Lisbon, Portugal $1 https://orcid.org/0000000328955821
- 700 1_
- $a Revés, Joana $u Division of Gastroenterology, Hospital Beatriz Ângelo, Loures, Lisbon, Portugal
- 700 1_
- $a Karmiris, Konstantinos $u Department of Gastroenterology, Venizeleio General Hospital, Heraklion, Crete, Greece
- 700 1_
- $a Velegraki, Magdalini $u Department of Gastroenterology, Venizeleio General Hospital, Heraklion, Crete, Greece $1 https://orcid.org/0000000341280718
- 700 1_
- $a Savarino, Edoardo $u Department of Surgical Oncological & Gastroenterological Sciences (DiSCOG), Gastroenterology Unit, Padua University, Padua, Italy
- 700 1_
- $a Markopoulos, Panagiotis $u Department of Gastroenterology, Metaxa Memorial General Hospital, Piraeus, Greece
- 700 1_
- $a Tsironi, Eftychia $u Department of Gastroenterology, Metaxa Memorial General Hospital, Piraeus, Greece
- 700 1_
- $a Ellul, Pierre $u Division of Gastroenterology Mater Dei Hospital, Msida, Malta
- 700 1_
- $a Calviño Suárez, Cristina $u Department of Gastroenterology and Hepatology, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain
- 700 1_
- $a Weisshof, Roni $u Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel $u Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Ben-Hur, Dana $u Department of Gastroenterology, Rambam Health Care Campus, Haifa, Israel $u Rappaport Faculty of Medicine, The Technion - Israel Institute of Technology, Haifa, Israel
- 700 1_
- $a Naftali, Timna $u Institute of Gastroenterology, Meir Hospital Sapir Medical Center, Kfar Saba, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Eriksson, Carl $u Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden $1 https://orcid.org/000000021046383X
- 700 1_
- $a Koutroubakis, Ioannis E $u Gastroenterology Department, University Hospital of Heraklion, Crete, Greece
- 700 1_
- $a Foteinogiannopoulou, Kalliopi $u Gastroenterology Department, University Hospital of Heraklion, Crete, Greece $1 https://orcid.org/0000000305545256
- 700 1_
- $a Limdi, Jimmy K $u Department of Gastroenterology, The Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Sciences, University of Manchester, Manchester, UK
- 700 1_
- $a Liu, Eleanor $u Department of Gastroenterology, The Northern Care Alliance NHS Foundation Trust, Manchester Academic Health Sciences, University of Manchester, Manchester, UK
- 700 1_
- $a Surís, Gerard $u Gastroenterology Department, Hospital de Bellvitge and IDIBELL, L'Hospitalet, Spain
- 700 1_
- $a Calabrese, Emma $u Gastroenterology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Italy
- 700 1_
- $a Zorzi, Francesca $u Gastroenterology Unit, Department of Systems Medicine, University of Rome Tor Vergata, Italy
- 700 1_
- $a Filip, Rafał $u Department of Gastroenterology with IBD Unit, Clinical Hospital No. 2, Rzeszów, Poland
- 700 1_
- $a Ribaldone, Davide Giuseppe $u Department of Medical Sciences, University of Turin, Turin, Italy $1 https://orcid.org/0000000294213087
- 700 1_
- $a Snir, Yifat $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Goren, Idan $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel $1 https://orcid.org/0000000221622840
- 700 1_
- $a Banai-Eran, Hagar $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Broytman, Yelena $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Amir Barak, Hadar $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Avni-Biron, Irit $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel $1 https://orcid.org/0000000191426530
- 700 1_
- $a Ollech, Jacob E $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Dotan, Iris $u Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Israel $u Sackler Faculty of Medicine, Tel Aviv University, Israel
- 700 1_
- $a Aharoni Golan, Maya $u Department of Gastroenterology and Hepatology, Kaplan Medical Center, Rehovot, Israel $u Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel $u Concord Medical Center, Clalit Health Services, Bnei Brak, Israel
- 773 0_
- $w MED00166945 $t Journal of Crohn's & colitis $x 1876-4479 $g Roč. 16, č. 12 (2022), s. 1882-1892
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/35895074 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230120 $b ABA008
- 991 __
- $a 20230131151534 $b ABA008
- 999 __
- $a ok $b bmc $g 1891167 $s 1183585
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2022 $b 16 $c 12 $d 1882-1892 $e 2022Dec05 $i 1876-4479 $m Journal of Crohn's and colitis $n J Crohns Colitis $x MED00166945
- LZP __
- $a Pubmed-20230120
