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Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells

J. Zarubova, MM. Hasani-Sadrabadi, SCP. Norris, FS. Majedi, C. Xiao, AM. Kasko, S. Li

. 2022 ; 18 (50) : e2203515. [pub] 20221028

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc22032350

Grantová podpora
R01 CA234343 NCI NIH HHS - United States
R56 DE029157 NIDCR NIH HHS - United States

Cell clusters that collectively migrate from primary tumors appear to be far more potent in forming distant metastases than single cancer cells. A better understanding of the collective cell migration phenomenon and the involvement of various cell types during this process is needed. Here, an in vitro platform based on inverted-pyramidal microwells to follow and quantify the collective migration of hundreds of tumor cell clusters at once is developed. These results indicate that mesenchymal stromal cells (MSCs) or cancer-associated fibroblasts (CAFs) in the heterotypic tumor cell clusters may facilitate metastatic dissemination by transporting low-motile cancer cells in a Rac-dependent manner and that extracellular vesicles secreted by mesenchymal cells only play a minor role in this process. Furthermore, in vivo studies show that cancer cell spheroids containing MSCs or CAFs have faster spreading rates. These findings highlight the active role of co-traveling stromal cells in the collective migration of tumor cell clusters and may help in developing better-targeted therapies.

Citace poskytuje Crossref.org

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