OBJECTIVE: Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase insulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GDM) and its complications for mothers and fetuses. DESIGN: This study aimed to assess serum levels and cord blood levels of IGF system components in pregnant women with (39 participants) and without GDM (22 participants). Blood samples were obtained at 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. Cord blood samples were obtained during delivery. Results between both groups as well as between single visits were statistically compared. RESULTS: Both IGF1 and IGF2 maternal serum levels did not differ between the GDM and non-GDM groups. However, levels of IGF-binding proteins (IGFBPs) were different. IGFBP4 levels were decreased during pregnancy and after delivery in women with GDM, while IGFBP7 levels were increased during pregnancy in women with GDM. Cord blood IGFBP3 and IGFBP7 levels were increased (p < 0.001 for IGFBP3, p = 0.003 for IGFBP7), while IGFBP4 levels were decreased (p < 0.001) in the GDM group compared with the non-GDM group. CONCLUSIONS: Although IGF levels did not differ, changes in their function level could still persist possibly because of the effects of the binding proteins, especially their promoting or inhibitory effects on IGFs. These results should be considered in interpretation of IGF levels.

3rd Department of Internal Medicine 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic

Centre for Experimental Medicine Institute for Clinical and Experimental Medicine Prague Czech Republic

Department of Gynecology and Obstetrics 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic

Diabetes Centre Institute for Clinical and Experimental Medicine Prague Czech Republic

Institute of Medical Biochemistry and Laboratory Diagnostics 1st Faculty of Medicine Charles University and General University Hospital Prague Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc22032366

003      

CZ-PrNML

005      

20230131151137.0

007      

ta

008      

230120s2022 Sco f 000 0|00 0|

009      

AR

024    7_

$a 10.1016/j.ghir.2022.101511 $2 doi

035    __

$a (PubMed)36252390

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a Scotland

100    1_

$a Anderlová, Kateřina $u Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

245    10

$a Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins / $c K. Anderlová, A. Cinkajzlová, P. Šimják, J. Kloučková, H. Kratochvílová, Z. Lacinová, V. Toušková, H. Krejčí, M. Mráz, A. Pařízek, M. Haluzík, M. Kršek

520    9_

$a OBJECTIVE: Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase insulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GDM) and its complications for mothers and fetuses. DESIGN: This study aimed to assess serum levels and cord blood levels of IGF system components in pregnant women with (39 participants) and without GDM (22 participants). Blood samples were obtained at 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. Cord blood samples were obtained during delivery. Results between both groups as well as between single visits were statistically compared. RESULTS: Both IGF1 and IGF2 maternal serum levels did not differ between the GDM and non-GDM groups. However, levels of IGF-binding proteins (IGFBPs) were different. IGFBP4 levels were decreased during pregnancy and after delivery in women with GDM, while IGFBP7 levels were increased during pregnancy in women with GDM. Cord blood IGFBP3 and IGFBP7 levels were increased (p &lt; 0.001 for IGFBP3, p = 0.003 for IGFBP7), while IGFBP4 levels were decreased (p &lt; 0.001) in the GDM group compared with the non-GDM group. CONCLUSIONS: Although IGF levels did not differ, changes in their function level could still persist possibly because of the effects of the binding proteins, especially their promoting or inhibitory effects on IGFs. These results should be considered in interpretation of IGF levels.

650    _2

$a lidé $7 D006801

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a těhotenství $7 D011247

650    12

$a gestační diabetes $x metabolismus $7 D016640

650    _2

$a biologická dostupnost $7 D001682

650    _2

$a proteiny vázající insulinu podobné růstové faktory $x metabolismus $7 D018969

650    _2

$a fetální krev $x metabolismus $7 D005312

650    12

$a inzulinová rezistence $7 D007333

655    _2

$a časopisecké články $7 D016428

655    _2

$a práce podpořená grantem $7 D013485

700    1_

$a Cinkajzlová, Anna $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Šimják, Patrik $u Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

700    1_

$a Kloučková, Jana $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Kratochvílová, Helena $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Lacinová, Zdeňka $u 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Centre for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Toušková, Věra $u 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

700    1_

$a Krejčí, Hana $u 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

700    1_

$a Mráz, Miloš $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Pařízek, Antonín $u Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic

700    1_

$a Haluzík, Martin $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic; Diabetes Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Kršek, Michal $u 3rd Department of Internal Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Electronic address: michal.krsek@vfn.cz

773    0_

$w MED00005163 $t Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society $x 1532-2238 $g Roč. 67, č. - (2022), s. 101511

856    41

$u https://pubmed.ncbi.nlm.nih.gov/36252390 $y Pubmed

910    __

$a ABA008 $b sig $c sign $y p $z 0

990    __

$a 20230120 $b ABA008

991    __

$a 20230131151133 $b ABA008

999    __

$a ok $b bmc $g 1891245 $s 1183701

BAS    __

$a 3

BAS    __

$a PreBMC-MEDLINE

BMC    __

$a 2022 $b 67 $c - $d 101511 $e 20221003 $i 1532-2238 $m Growth hormone & IGF research $n Growth Horm IGF Res $x MED00005163

LZP    __

$a Pubmed-20230120