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Effects of oleanolic acid on hair growth in mouse dorsal skin mediated via regulation of inflammatory cytokines

B. Zhang, W. Zhang, J. Luo, J. He, X. Zheng, S. Zhu, B. Rong, Y. Ai, L. Zhang, T. He

. 2023 ; 21 (1) : 48-57. [pub] 20230327

Language English Country Czech Republic

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc23002236

Grant support
2019-R01-6 The Innovation and Entrepreneurship Leading Team Project of Panyu District - China
2021GDKLPRB02 Guangdong Provincial Key Laboratory of Plant Resources Biorefinery - China

Oleanolic acid (OA) is a pentacyclic triterpenoid with favourable physiological activity. It is widely distributed in more than 200 species of plants. OA has garnered significant interest because of its potential biological activities, such as antioxidant, bacteriostatic, and hair growth-promoting effects. To study the effect of OA on hair growth and related mechanisms, we investigated hair growth in mice with testosterone-induced androgenetic alopecia (AGA) that were treated with three different concentrations of OA. The antioxidant, bacteriostatic, and cytotoxic effects of OA were evaluated. We found that mice with testosterone-induced AGA treated with 1% or 0.5% OA showed significantly enhanced hair growth and increased vascular endothelial growth factor/glyceraldehyde-3-phosphate dehydrogenase ratio and levels of fibroblast growth factor receptor and insulin-like growth factor 1. Using an immunofluorescence staining assay, we demonstrated that β-catenin, a key Wnt signalling transducer, was highly expressed in the OA-treated groups. These results suggest that OA may promote hair growth by stimulating hair matrix cell proliferation via the Wnt/β-catenin pathway and lowering the levels of tumour necrosis factor-alpha, and transforming growth factor-beta 1, dihydrotestosterone, and 5α-reductase.

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