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Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry
G. De Luca, M. Algowhary, B. Uguz, DC. Oliveira, V. Ganyukov, O. Busljetik, M. Cercek, LO. Jensen, PH. Loh, L. Calmac, GRI. Ferrer, A. Quadros, M. Milewski, F. Scotto D'Uccio, C. von Birgelen, F. Versaci, J. Ten Berg, G. Casella, A. Wong Sung...
Status neindexováno Jazyk angličtina Země Švýcarsko
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 2012
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2019-01-01
Open Access Digital Library
od 2012-01-01
Open Access Digital Library
od 2012-01-01
Health & Medicine (ProQuest)
od 2019-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2012
PubMed
36983119
DOI
10.3390/jcm12062116
Knihovny.cz E-zdroje
- Publikační typ
- časopisecké články MeSH
BACKGROUND: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. METHODS: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or ≥75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. RESULTS: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. CONCLUSIONS: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.
Azienda Ospedaliero Universitaria Ospedali Riuniti Trieste 34142 Trieste Italy
Cardiology Azienda Ospedaliera Lavagna 16033 Lavagna Italy
Cardiology Department Hospital Garcia de Orta Pragal 2805 267 Almada Portugal
Cardiology H Universitario y Politécnico La Fe 46001 Valencia Spain
Cardiology Institute Instanbul University 34000 Istanbul Türkiye
Center for Cardiovascular Diseases 6000 Ohrid North Macedonia
Center Hospitalierd'Antibes Juan Les Pins 06600 Antibes France
Central Hospital Medical University of Lodz 90 008 Lodz Poland
Clinic Emergency Hospital of Bucharest 010001 Bucharest Romania
Complexo Hospetaliero Universitario La Coruna 15001 La Coruna Spain
Department of Cardiology Hospital Bezmialem Vakıf University 34093 Istanbul Türkiye
Department of Cardiology Medical Center Ljubljana 1000 Ljubljana Slovenia
Department of Cardiology Medisch Spectrum Twente Thoraxcentrum Twente 7541 Enschede The Netherlands
Department of Cardiology National Heart Center Singapore 169609 Singapore
Department of Cardiology National University Hospital Singapore 119074 Singapore
Department of Cardiology Queen Elizabeth Hospital University of Hong Kong Hong Kong
Department of Cardiology Queen Mary Hospital University of Hong Kong Hong Kong
Department of Cardiology University Hospital Centre University of Zagreb 10000 Zagreb Croatia
Department of Clinical and Experimental Medicine University of Messina 98122 Messina Italy
Department of Internal Medicine Ospedale Riuniti 25121 Brescia Italy
Department of Statistical Sciences University of Padova 35121 Padova Italy
Division of Cardiology Alexandra Hospital 10431 Athens Greece
Division of Cardiology AOU Policlinico G Martino 98124 Messina Italy
Division of Cardiology Assiut University Heart Hospital Assiut University Asyut 71515 Egypt
Division of Cardiology Attikon University Hospital 10431 Athens Greece
Division of Cardiology AUSL IRCCS Reggio Emilia 42121 Reggio Emilia Italy
Division of Cardiology Azienda Ospedaliera Ospedali Riuniti Marche Nord 61121 Pesaro Italy
Division of Cardiology Blida University Hospital Blida 0900 Algeria
Division of Cardiology Bursa City Hospital 16110 Bursa Türkiye
Division of Cardiology Center Hospitalier Universitaire de Lille 59000 Lille France
Division of Cardiology CHU Lariboisière AP HP Paris 7 University INSERM UMRS 942 75010 Paris France
Division of Cardiology Clinica Villa dei Fiori 80011 Acerra Italy
Division of Cardiology Complejo Hospitalario de Toledo 45001 Toledo Spain
Division of Cardiology Faculty of Medicine Eskisehir Osmangazi University 02640 Eskisehir Türkiye
Division of Cardiology Galeazzi Sant'Ambrogio Hospital 20157 Milan Italy
Division of Cardiology Groupe Hospitalier Mutualiste de Grenoble 38000 Grenoble France
Division of Cardiology Heart Centre Turku 20521 Turku Finland
Division of Cardiology Hopital Erasmus Universitè Libre de Bruxelles 1050 Bruxelles Belgium
Division of Cardiology Hospital Cabueñes 33201 Gijon Spain
Division of Cardiology Hospital Clinico Universitario de Valencia 46010 Valencia Spain
Division of Cardiology Hospital Cordoba Cordoba 5000 Argentina
Division of Cardiology Hospital de Santa Cruz CHLO Nova Medical School 1000 Lisbon Portugal
Division of Cardiology Hospital de Santo António 4099 001 Porto Portugal
Division of Cardiology Hospital Puerta de Hierro Majadahonda 28222 Madrid Spain
Division of Cardiology Hospital Puerta del Mar 11001 Cadiz Spain
Division of Cardiology Hospital Universitario de Canarias 38001 Santa Cruz de Tenerife Spain
Division of Cardiology Kontantopoulion Hospital 10431 Athens Greece
Division of Cardiology Medical University of Silezia 40 002 Katowice Poland
Division of Cardiology Northwest Clinics 1811 Alkmaar The Netherlands
Division of Cardiology Odense Universitets Hospital 5000 Odense Denmark
Division of Cardiology Ospedale A Manzoni 23900 Lecco Italy
Division of Cardiology Ospedale Civico Arnas 90100 Palermo Italy
Division of Cardiology Ospedale degli Infermi ASL 13900 Biella Italy
Division of Cardiology Ospedale del Mare 80147 Napoli Italy
Division of Cardiology Ospedale F Spaziani 03100 Frosinone Italy
Division of Cardiology Ospedale G Moscati 81031 Aversa Italy
Division of Cardiology Ospedale Maggiore Bologna 40100 Bologna Italy
Division of Cardiology Ospedale S Maurizio 39100 Bolzano Italy
Division of Cardiology Ospedale San Giovanni di Dio e Ruggid'Aragona 84070 Salerno Italy
Division of Cardiology Ospedale Sant'Anna 44121 Ferrara Italy
Division of Cardiology Ospedale Santa Chiara di Trento 38014 Trento Italy
Division of Cardiology Ospedale Santa Maria delle Grazie 80078 Pozzuoli Italy
Division of Cardiology Ospedale Santa Maria Goretti Latina 04100 Latina Italy
Division of Cardiology Otamendi Hospital Buenos Aires 1001 Argentina
Division of Cardiology Oulu University Hospital 90220 Oulu Finland
Division of Cardiology Radboud University Medical Center 6525 Nijmegen The Netherlands
Division of Cardiology St Antonius Hospital 3434 Nieuwegein The Netherlands
Division of Cardiology UMC Utrecht 3584 Utrecht The Netherlands
Division of Cardiology Universidad UPB CES Medellin 050001 Colombia
Hospital Clínico Universitario Virgen de la Victoria 290000 Malaga Spain
Hospital Germans Triasi Pujol 8918 Badalona Spain
Instituto Cardiovascular de Buenos Aires 6302 Buenos Aires C1428 CABA Argentina
Instituto de Cardiologia de Santa Catarina Praia Comprida São José 88100 000 Brazil
Instituto de Cardiologia do Rio Grande do Sul Porto Alegre 90000 00 Brazil
Instituto de Cardiologia Integral Montevideo 11700 Uruguay
Interventional Cardiolgy Unit IRCCS INRCA 60131 Ancona Italy
Interventional Cardiology Unit Azienda Ospedaliera Sanitaria 43121 Parma Italy
Invasive Cardiology and Congenital Heart Disease Patras University Hospital 26221 Patras Greece
Iraklion University Hospital 70001 Crete Greece
Maastricht University Medical Center 6229 HX Maastricht The Netherlands
Tyumen Cardiology Research Center 625026 Tyumen Russia
University Hospital Brno Medical Faculty of Masaryk University Brno 60200 Bohunice Czech Republic
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