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ONEST (Observers Needed to Evaluate Subjective Tests) Analysis of Stromal Tumour-Infiltrating Lymphocytes (sTILs) in Breast Cancer and Its Limitations

B. Cserni, D. Kilmartin, M. O'Loughlin, X. Andreu, Z. Bagó-Horváth, S. Bianchi, E. Chmielik, P. Figueiredo, G. Floris, MP. Foschini, A. Kovács, P. Heikkilä, J. Kulka, AV. Laenkholm, I. Liepniece-Karele, C. Marchiò, E. Provenzano, P. Regitnig, A....

. 2023 ; 15 (4) : . [pub] 20230214

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc23002928

Tumour-infiltrating lymphocytes (TILs) reflect antitumour immunity. Their evaluation of histopathology specimens is influenced by several factors and is subject to issues of reproducibility. ONEST (Observers Needed to Evaluate Subjective Tests) helps in determining the number of observers that would be sufficient for the reliable estimation of inter-observer agreement of TIL categorisation. This has not been explored previously in relation to TILs. ONEST analyses, using an open-source software developed by the first author, were performed on TIL quantification in breast cancers taken from two previous studies. These were one reproducibility study involving 49 breast cancers, 23 in the first circulation and 14 pathologists in the second circulation, and one study involving 100 cases and 9 pathologists. In addition to the estimates of the number of observers required, other factors influencing the results of ONEST were examined. The analyses reveal that between six and nine observers (range 2-11) are most commonly needed to give a robust estimate of reproducibility. In addition, the number and experience of observers, the distribution of values around or away from the extremes, and outliers in the classification also influence the results. Due to the simplicity and the potentially relevant information it may give, we propose ONEST to be a part of new reproducibility analyses.

Department of Clinical Pathology Sahlgrenska University Hospital 41345 Gothenburg Sweden

Department of Histopathology Cambridge University Hospitals National Health Service Foundation Trust Cambridge CB2 0QQ UK

Department of Histopathology Irish National Breast Screening Programme BreastCheck St Vincent's University Hospital and School of Medicine University College Dublin D04 T6F4 Dublin Ireland

Department of Medical Physics and Informatics University of Szeged 6720 Szeged Hungary

Department of Medical Sciences University of Turin 10126 Turin Italy

Department of Pathology Bács Kiskun County Teaching Hospital 6000 Kecskemét Hungary

Department of Pathology Forensic and Insurance Medicine Semmelweis University Budapest Üllői út 93 1091 Budapest Hungary

Department of Pathology Helsinki University Central Hospital 00029 Helsinki Finland

Department of Pathology Klinikum Donaustadt 1090 Vienna Austria

Department of Pathology Medical University of Vienna Währinger Gürtel 18 20 1090 Vienna Austria

Department of Pathology Riga Stradins University Riga East Clinical University Hospital LV 1038 Riga Latvia

Department of Pathology School of Medicine University of Patras 26504 Rion Greece

Department of Pathology University of Szeged 6720 Szeged Hungary

Department of Surgical Pathology Zealand University Hospital 4000 Roskilde Denmark

Diagnostic and Research Institute of Pathology Medical University of Graz 8010 Graz Austria

Discipline of Pathology Lambe Institute for Translational Research School of Medicine University of Galway H91 TK33 Galway Ireland

Division of Pathological Anatomy Department of Health Sciences University of Florence 50134 Florence Italy

Laboratório de Anatomia Patológica IPO Coimbra 3000 075 Coimbra Portugal

Laboratory of Translational Cell and Tissue Research and KU Leuven Department of Imaging and Pathology Department of Pathology University Hospitals Leuven University of Leuven Oude Market 13 3000 Leuven Belgium

National Institute for Health Research Cambridge Biomedical Research Centre Cambridge CB2 0QQ UK

Pathology Department Atryshealth Co Ltd 08039 Barcelona Spain

Pathology Department Herlev University Hospital DK 2730 Herlev Denmark

School of Medicine University College Dublin D04 V1W8 Dublin Ireland

The Fingerland Department of Pathology Charles University Medical Faculty and University Hospital 50003 Hradec Kralove Czech Republic

TNG Technology Consulting GmbH Király u 26 1061 Budapest Hungary

Tumor Pathology Department Maria Sklodowska Curie National Research Institute of Oncology Gliwice Branch 44 102 Gliwice Poland

Unit of Anatomic Pathology Department of Biomedical and Neuromotor Sciences University of Bologna Bellaria Hospital 40139 Bologna Italy

Unit of Pathology Candiolo Cancer Institute FPO IRCCS 10060 Candiolo Italy

Citace poskytuje Crossref.org

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