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Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study
SN. Do, CX. Dao, TA. Nguyen, MH. Nguyen, DT. Pham, NT. Nguyen, DQ. Huynh, QTA. Hoang, CV. Bui, TD. Vu, HN. Bui, HT. Nguyen, HB. Hoang, TTP. Le, LTB. Nguyen, PT. Duong, TD. Nguyen, VH. Le, GTT. Pham, GTH. Bui, TV. Bui, TTN. Pham, CV. Nguyen, AD....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu multicentrická studie, časopisecké články
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- MeSH
- dospělí MeSH
- jednotky intenzivní péče MeSH
- lidé MeSH
- obyvatelé jihovýchodní Asie MeSH
- prognóza MeSH
- průřezové studie MeSH
- retrospektivní studie MeSH
- ROC křivka MeSH
- sepse * MeSH
- vyhodnocení orgánové dysfunkce * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- Geografické názvy
- Vietnam MeSH
OBJECTIVES: To compare the accuracy of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Scores in predicting mortality among intensive care unit (ICU) patients with sepsis in a low-income and middle-income country. DESIGN: A multicentre, cross-sectional study. SETTING: A total of 15 adult ICUs throughout Vietnam. PARTICIPANTS: We included all patients aged ≥18 years who were admitted to ICUs for sepsis and who were still in ICUs from 00:00 to 23:59 of the specified study days (ie, 9 January, 3 April, 3 July and 9 October of the year 2019). PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was hospital all-cause mortality (hospital mortality). We also defined the secondary outcome as all-cause deaths in the ICU (ICU mortality). RESULTS: Of 252 patients, 40.1% died in hospitals, and 33.3% died in ICUs. SOFA Score (areas under the receiver operating characteristic curve (AUROC): 0.688 (95% CI 0.618 to 0.758); cut-off value≥7.5; PAUROC<0.001) and APACHE II Score (AUROC: 0.689 (95% CI 0.622 to 0.756); cut-off value ≥20.5; PAUROC<0.001) both had a poor discriminatory ability for predicting hospital mortality. However, the discriminatory ability for predicting ICU mortality of SOFA (AUROC: 0.713 (95% CI 0.643 to 0.783); cut-off value≥9.5; PAUROC<0.001) was fair and was better than that of APACHE II Score (AUROC: 0.672 (95% CI 0.603 to 0.742); cut-off value≥18.5; PAUROC<0.001). A SOFA Score≥8 (adjusted OR (AOR): 2.717; 95% CI 1.371 to 5.382) and an APACHE II Score≥21 (AOR: 2.668; 95% CI 1.338 to 5.321) were independently associated with an increased risk of hospital mortality. Additionally, a SOFA Score≥10 (AOR: 2.194; 95% CI 1.017 to 4.735) was an independent predictor of ICU mortality, in contrast to an APACHE II Score≥19, for which this role did not. CONCLUSIONS: In this study, SOFA and APACHE II Scores were worthwhile in predicting mortality among ICU patients with sepsis. However, due to better discrimination for predicting ICU mortality, the SOFA Score was preferable to the APACHE II Score in predicting mortality.Clinical trials registry - India: CTRI/2019/01/016898.
Center for Critical Care Medicine Bach Mai Hospital Hanoi Viet Nam
Center for Emergency Medicine Bach Mai Hospital Hanoi Viet Nam
Department of Emergency and Critical Care Medicine Hanoi Medical University Hanoi Viet Nam
Department of Intensive Care Medicine Woodlands Health Singapore
Emergency Department Hue Central General Hospital Hue City Thua Thien Hue Viet Nam
Emergency Department Thanh Nhan General Hospital Hanoi Viet Nam
Faculty of Medicine University of Medicine and Pharmacy Vietnam National University Hanoi Vietnam
FAST and Chronic Programmes Alexandra Hospital National University Health System Singapore
Intensive Care Department Cho Ray Hospital Ho Chi Minh City Viet Nam
Intensive Care Unit 115 People's Hospital Ho Chi Minh City Viet Nam
Intensive Care Unit Bai Chay General Hospital Ha Long City Quang Ninh Viet Nam
Intensive Care Unit Can Tho Central General Hospital Can Tho Viet Nam
Intensive Care Unit Da Nang Hospital Da Nang City Viet Nam
Intensive Care Unit Dong Da General Hospital Hanoi Viet Nam
Intensive Care Unit Saint Paul General Hospital Hanoi Viet Nam
Intensive Care Unit Thai Nguyen Central General Hospital Thai Nguyen City Thai Nguyen Viet Nam
Intensive Care Unit Vinmec Times City International Hospital Hanoi Viet Nam
Citace poskytuje Crossref.org
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