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The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis
K. Ženíšková, J. Mach, D. Arbon, J. Štursa, L. Werner, M. Zoltner, R. Sutak
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
Free Medical Journals
from 1972 to 6 months ago
Freely Accessible Science Journals
from 1995 to 6 months ago
PubMed Central
from 1972 to 1 year ago
Europe PubMed Central
from 1972 to 6 months ago
Open Access Digital Library
from 1972-01-01
Open Access Digital Library
from 1972-01-01
PubMed
36688657
DOI
10.1128/aac.01506-22
Knihovny.cz E-resources
- MeSH
- Amebiasis * drug therapy MeSH
- Blood-Brain Barrier MeSH
- Meningoencephalitis * MeSH
- Mice MeSH
- Naegleria fowleri * MeSH
- Central Nervous System Protozoal Infections * drug therapy MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Primary amoebic meningoencephalitis is a rare but fatal central nervous system (CNS) disease caused by the "brain-eating amoeba" Naegleria fowleri. A major obstacle is the requirement for drugs with the ability to cross the blood-brain barrier, which are used in extremely high doses, cause severe side effects, and are usually ineffective. We discovered that the 4-aminomethylphenoxy-benzoxaborole AN3057 exhibits nanomolar potency against N. fowleri, and experimental treatment of infected mice significantly prolonged survival and demonstrated a 28% relapse-free cure rate.
Department of Parasitology Faculty of Science Charles University BIOCEV Vestec Czech Republic
Institute of Biotechnology Czech Academy of Sciences BIOCEV Vestec Czech Republic
References provided by Crossref.org
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