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The 4-Aminomethylphenoxy-Benzoxaborole AN3057 as a Potential Treatment Option for Primary Amoebic Meningoencephalitis
K. Ženíšková, J. Mach, D. Arbon, J. Štursa, L. Werner, M. Zoltner, R. Sutak
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Freely Accessible Science Journals od 1995 do Před 6 měsíci
PubMed Central od 1972 do Před 6 měsíci
Europe PubMed Central od 1972 do Před 6 měsíci
Open Access Digital Library od 1972-01-01
Open Access Digital Library od 1972-01-01
Odkazy
PubMed
36688657
DOI
10.1128/aac.01506-22
Knihovny.cz E-zdroje
- MeSH
- amébiáza * farmakoterapie MeSH
- hematoencefalická bariéra MeSH
- meningoencefalitida * MeSH
- myši MeSH
- Naegleria fowleri * MeSH
- protozoární infekce centrálního nervového systému * farmakoterapie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Primary amoebic meningoencephalitis is a rare but fatal central nervous system (CNS) disease caused by the "brain-eating amoeba" Naegleria fowleri. A major obstacle is the requirement for drugs with the ability to cross the blood-brain barrier, which are used in extremely high doses, cause severe side effects, and are usually ineffective. We discovered that the 4-aminomethylphenoxy-benzoxaborole AN3057 exhibits nanomolar potency against N. fowleri, and experimental treatment of infected mice significantly prolonged survival and demonstrated a 28% relapse-free cure rate.
Department of Parasitology Faculty of Science Charles University BIOCEV Vestec Czech Republic
Institute of Biotechnology Czech Academy of Sciences BIOCEV Vestec Czech Republic
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