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EBV-driven lymphoid neoplasms associated with pediatric ALL maintenance therapy
S. Elitzur, A. Vora, B. Burkhardt, H. Inaba, A. Attarbaschi, A. Baruchel, G. Escherich, B. Gibson, HC. Liu, M. Loh, AV. Moorman, A. Möricke, R. Pieters, A. Uyttebroeck, S. Baird, J. Bartram, S. Barzilai-Birenboim, S. Batra, M. Ben-Harosh, Y....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 1946 do Před 1 rokem
Freely Accessible Science Journals
od 1946 do Před 1 rokem
Open Access Digital Library
od 1946-01-01
Open Access Digital Library
od 1946-01-01
ROAD: Directory of Open Access Scholarly Resources
PubMed
36332176
DOI
10.1182/blood.2022016975
Knihovny.cz E-zdroje
- MeSH
- akutní lymfatická leukemie * terapie komplikace MeSH
- dítě MeSH
- infekce virem Epsteina-Barrové * komplikace diagnóza MeSH
- lidé MeSH
- lymfom * komplikace MeSH
- nehodgkinský lymfom * patologie MeSH
- sekundární malignity * MeSH
- virus Epsteinův-Barrové MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
The development of a second malignancy after the diagnosis of childhood acute lymphoblastic leukemia (ALL) is a rare event. Certain second malignancies have been linked with specific elements of leukemia therapy, yet the etiology of most second neoplasms remains obscure and their optimal management strategies are unclear. This is a first comprehensive report of non-Hodgkin lymphomas (NHLs) following pediatric ALL therapy, excluding stem-cell transplantation. We analyzed data of patients who developed NHL following ALL diagnosis and were enrolled in 12 collaborative pediatric ALL trials between 1980-2018. Eighty-five patients developed NHL, with mature B-cell lymphoproliferations as the dominant subtype (56 of 85 cases). Forty-six of these 56 cases (82%) occurred during or within 6 months of maintenance therapy. The majority exhibited histopathological characteristics associated with immunodeficiency (65%), predominantly evidence of Epstein-Barr virus-driven lymphoproliferation. We investigated 66 cases of post-ALL immunodeficiency-associated lymphoid neoplasms, 52 from our study and 14 additional cases from a literature search. With a median follow-up of 4.9 years, the 5-year overall survival for the 66 patients with immunodeficiency-associated lymphoid neoplasms was 67.4% (95% confidence interval [CI], 56-81). Five-year cumulative risks of lymphoid neoplasm- and leukemia-related mortality were 20% (95% CI, 10.2-30) and 12.4% (95% CI, 2.7-22), respectively. Concurrent hemophagocytic lymphohistiocytosis was associated with increased mortality (hazard ratio, 7.32; 95% CI, 1.62-32.98; P = .01). A large proportion of post-ALL lymphoid neoplasms are associated with an immunodeficient state, likely precipitated by ALL maintenance therapy. Awareness of this underrecognized entity and pertinent diagnostic tests are crucial for early diagnosis and optimal therapy.
Amsterdam Academic Medical Center Emma Children's Hospital Amsterdam The Netherlands
Beatson West of Scotland Cancer Centre Glasgow United Kingdom
Cancer and Blood Disorders Institute Johns Hopkins All Children's Hospital St Petersburg FL
Children's Hospital Western University London ON Canada
Department of Haematology Royal Hospital for Children and Young People Edinburgh United Kingdom
Department of Oncology St Jude Children's Research Hospital Memphis TN
Department of Paediatric Haematology and Oncology University Hospital Leuven Leuven Leuven Belgium
Department of Paediatric Haematology Great Ormond Street Hospital London United Kingdom
Department of Paediatric Haematology Royal Hospital for Children Glasgow United Kingdom
Department of Pathology School of Medicine La Plata National University La Plata Argentina
Department of Pediatric Oncology and Hematology Hospital Luis Calvo Mackenna Santiago Chile
Department of Pediatric Oncology Centre Hospitalier Universitaire de Montpellier Montpellier France
Department of Pediatric Oncology University Children's Hospital Zurich Switzerland
Department of Pediatrics and Adolescent Medicine Kepler University Clinic Linz Austria
Department of Pediatrics Hokkaido University Graduate School of Medicine Sapporo Japan
Department of Statistics and Data Science Hebrew University Jerusalem Israel
Institut d'Hematologie et d'Oncologie Pediatrique Hospices Civils de Lyon Lyon France
Paediatric Oncology Leeds Children's Hospital Leeds United Kingdom
Pediatric Hematology and Oncology University Hospital Münster Münster Germany
Pediatric Hematology Oncology Ochsner Children's Hospital New Orleans LA
Pediatric Oncology Nice University Hospital Nice France
Pediatrics and Adolescent Medicine University of Augsburg Augsburg Germany
Phoenix Children's Hospital Center for Cancer and Blood Disorders Phoenix AZ
Princess Máxima Center for Pediatric Oncology Utrecht The Netherlands
Shaare Zedek Medical Centre and The Faculty of Medicine Hebrew University Jerusalem Israel
Citace poskytuje Crossref.org
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