-
Je něco špatně v tomto záznamu ?
Lithium in breast milk transiently affects the renal electrolytic balance of infants
I. Ahmed, MS. Khan, V. Ma, H. Magsi, R. Gunawan, AO. Ilyas, NUR. Lashari, N. Wassan, S. Paidi, Z. Ali, AWL. Law, Y. Zhang, WC. Cho, M. Alda, V. Bergink, I. Barman, C. Lau
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
36409044
DOI
10.1111/bdi.13275
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha * farmakoterapie MeSH
- draslík analýza terapeutické užití MeSH
- kojenec MeSH
- kojení MeSH
- krysa rodu rattus MeSH
- ledviny MeSH
- lidé MeSH
- lithium terapeutické užití MeSH
- mateřské mléko * chemie MeSH
- zvířata MeSH
- Check Tag
- kojenec MeSH
- krysa rodu rattus MeSH
- lidé MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: The use of lithium during breast-feeding has not been comprehensively investigated in humans due to concerns about lithium toxicity. PROCEDURE: We analyzed lithium in the kidneys of nursed pups of lithium medicated mothers, using analytical spectroscopy in a novel rat model. The mothers were healthy rats administered lithium via gavage (1000 mg/day Li2 CO3 per 50 kg body weight). RESULTS: Lithium was detected in the breast milk, and in the blood of pups (0.08 mM), of lithium-exposed dams at post-natal day 18 (P18), during breast-feeding. No lithium was detected after breast-feeding, at P25 (4 days after cessation of nursing). The lithium pups blood had elevated urea nitrogen at P18 and reduced total T4 at P18 and P25, indicating a longer-term effect on the kidneys and the thyroid gland. Multivariate machine-learning analysis of spectroscopy data collected from the excised kidneys of pups showed elevated potassium in lithium-exposed animals both during- and after breast-feeding. The elevated renal potassium was associated with low nephrin expression in the kidneys measured immunohistochemically during breast-feeding. After lithium exposure is stopped, the filtration of lithium from the kidneys reverses these effects. Our study showed that breastfeeding during lithium use has an effect on the kidneys of the offspring in rats.
Department of Business Administration Sukkur IBA University Sukkur Pakistan
Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong SAR China
Department of Electrical Engineering Sukkur IBA University Sukkur Pakistan
Department of Mechanical Engineering The University of Hong Kong Hong Kong SAR China
Department of Oncology Johns Hopkins University School of Medicine Baltimore Massachusetts USA
Department of Physics City University of Hong Kong Hong Kong SAR China
Department of Physics Federal University Oye Ekiti Ekiti State Nigeria
Department of Psychiatry Dalhousie University Halifax Canada
Department of Psychiatry Erasmus Medical Center Rotterdam The Netherlands
Department of Psychiatry Icahn School of Medicine at Mount Sinai New York City New York USA
Hong Kong Centre for Cerebro Cardiovascular Health Engineering Hong Kong SAR China
Institute for Advanced Study Shenzhen University Shenzhen China
Johns Hopkins University Department of Mechanical Engineering Baltimore Massachusetts USA
National Institute of Mental Health Klecany Czech Republic
School of Optometry University of California Berkeley California USA
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc23004390
- 003
- CZ-PrNML
- 005
- 20230425141339.0
- 007
- ta
- 008
- 230418s2023 dk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1111/bdi.13275 $2 doi
- 035 __
- $a (PubMed)36409044
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a dk
- 100 1_
- $a Ahmed, Irfan $u Department of Physics, City University of Hong Kong, Hong Kong SAR, China $u Department of Electrical Engineering, Sukkur IBA University, Sukkur, Pakistan
- 245 10
- $a Lithium in breast milk transiently affects the renal electrolytic balance of infants / $c I. Ahmed, MS. Khan, V. Ma, H. Magsi, R. Gunawan, AO. Ilyas, NUR. Lashari, N. Wassan, S. Paidi, Z. Ali, AWL. Law, Y. Zhang, WC. Cho, M. Alda, V. Bergink, I. Barman, C. Lau
- 520 9_
- $a BACKGROUND: The use of lithium during breast-feeding has not been comprehensively investigated in humans due to concerns about lithium toxicity. PROCEDURE: We analyzed lithium in the kidneys of nursed pups of lithium medicated mothers, using analytical spectroscopy in a novel rat model. The mothers were healthy rats administered lithium via gavage (1000 mg/day Li2 CO3 per 50 kg body weight). RESULTS: Lithium was detected in the breast milk, and in the blood of pups (0.08 mM), of lithium-exposed dams at post-natal day 18 (P18), during breast-feeding. No lithium was detected after breast-feeding, at P25 (4 days after cessation of nursing). The lithium pups blood had elevated urea nitrogen at P18 and reduced total T4 at P18 and P25, indicating a longer-term effect on the kidneys and the thyroid gland. Multivariate machine-learning analysis of spectroscopy data collected from the excised kidneys of pups showed elevated potassium in lithium-exposed animals both during- and after breast-feeding. The elevated renal potassium was associated with low nephrin expression in the kidneys measured immunohistochemically during breast-feeding. After lithium exposure is stopped, the filtration of lithium from the kidneys reverses these effects. Our study showed that breastfeeding during lithium use has an effect on the kidneys of the offspring in rats.
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a krysa rodu Rattus $7 D051381
- 650 _2
- $a kojenec $7 D007223
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a zvířata $7 D000818
- 650 12
- $a mateřské mléko $x chemie $7 D008895
- 650 _2
- $a lithium $x terapeutické užití $7 D008094
- 650 12
- $a bipolární porucha $x farmakoterapie $7 D001714
- 650 _2
- $a ledviny $7 D007668
- 650 _2
- $a draslík $x analýza $x terapeutické užití $7 D011188
- 650 _2
- $a kojení $7 D001942
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Khan, Muhammad Shehzad $u Department of Physics, City University of Hong Kong, Hong Kong SAR, China
- 700 1_
- $a Ma, Victor $u Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China
- 700 1_
- $a Magsi, Hina $u Department of Electrical Engineering, Sukkur IBA University, Sukkur, Pakistan
- 700 1_
- $a Gunawan, Renardi $u Department of Biomedical Sciences, and Tung Biomedical Sciences Centre, City University of Hong Kong, Hong Kong SAR, China
- 700 1_
- $a Ilyas, Abdul-Mojeed Olabisi $u Department of Physics, City University of Hong Kong, Hong Kong SAR, China $u Hong Kong Centre for Cerebro-Cardiovascular Health Engineering (COCHE), Hong Kong SAR, China $u Department of Physics, Federal University Oye-Ekiti, Ekiti State, Nigeria
- 700 1_
- $a Lashari, Najeeb Ur Rehman $u Institute for Advanced Study, Shenzhen University, Shenzhen, China $u Department of Chemistry Physics and Atmospheric Sciences, Jackson State University, Jackson, Mississippi, USA
- 700 1_
- $a Wassan, Naveed $u Department of Business Administration, Sukkur IBA University, Sukkur, Pakistan
- 700 1_
- $a Paidi, Santosh $u Johns Hopkins University, Department of Mechanical Engineering, Baltimore, Massachusetts, USA $u School of Optometry, University of California, Berkeley, California, USA
- 700 1_
- $a Ali, Zulfiqar $u Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China
- 700 1_
- $a Law, Alan W L $u Department of Physics, City University of Hong Kong, Hong Kong SAR, China
- 700 1_
- $a Zhang, Yanpeng $u Key Laboratory for Physical Electronics and Devices of the Ministry of Education & Shaanxi Key Lab of Information Photonic Technique, Xi'an Jiaotong University, Xi'an, China
- 700 1_
- $a Cho, William C $u Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China
- 700 1_
- $a Alda, Martin $u Department of Psychiatry, Dalhousie University, Halifax, Canada $u National Institute of Mental Health, Klecany, Czech Republic $1 https://orcid.org/0000000195443944 $7 xx0072985
- 700 1_
- $a Bergink, Veerle $u Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, New York, USA $u Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
- 700 1_
- $a Barman, Ishan $u Johns Hopkins University, Department of Mechanical Engineering, Baltimore, Massachusetts, USA $u Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Massachusetts, USA $u Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Massachusetts, USA
- 700 1_
- $a Lau, Condon $u Department of Physics, City University of Hong Kong, Hong Kong SAR, China $1 https://orcid.org/0000000265695814
- 773 0_
- $w MED00007648 $t Bipolar disorders $x 1399-5618 $g Roč. 25, č. 1 (2023), s. 56-65
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/36409044 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20230418 $b ABA008
- 991 __
- $a 20230425141336 $b ABA008
- 999 __
- $a ok $b bmc $g 1924837 $s 1190599
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2023 $b 25 $c 1 $d 56-65 $e 20221128 $i 1399-5618 $m Bipolar disorders $n Bipolar Disord $x MED00007648
- LZP __
- $a Pubmed-20230418
